Abstract: The present invention provides methods for preparing compositions in blister packages using complex aluminum substrate materials, wherein said complex aluminum substrate materials comprise an intermediate aluminum layer, and first and second outer layers, wherein the material of the first outer layer differs from that of the second outer layer, and the flexural rigidity of the first outer layer differs from that of the second outer layer by 0-30%.
Type:
Grant
Filed:
June 19, 2008
Date of Patent:
February 11, 2014
Assignee:
Quantum Hi-Tech (Beijing) Research Institute
Inventors:
Hewei Li, Congwei Wang, Bo Du, Chenggong Jia, Shirong Jiao, Chun Ji
Abstract: An orally disintegrating formulation and its preparation are provided. The orally disintegrating formulation comprises an effective amount of a pharmaceutically active ingredient and a matrix, wherein the matrix contains an amino acid and pullulan. The orally disintegrating formulation can disintegrate rapidly in oral cavity and be taken without aid of water; Moreover, the formulation has a low hygroscopicity, so that the requirements for storing or producing the formulation is decreased, and the storage life is elongated to facilitate the administration by a patient and the preparation of the protein and vaccine drugs.
Type:
Grant
Filed:
April 30, 2005
Date of Patent:
October 19, 2010
Assignee:
Quantum Hi-Tech (Beijing) Research Institute
Inventors:
Hewei Li, Hongfei Wang, Mingzhou Wang, Linyuan Wang
Abstract: An orally disintegrating formulation and its preparation are provided. The orally disintegrating formulation comprises an effective amount of a pharmaceutically active ingredient and a matrix, wherein the matrix contains an amino acid and pullulan. The orally disintegrating formulation can disintegrate rapidly in oral cavity and be taken without aid of water; Moreover, the formulation has a low hygroscopicity, so that the requirements for storing or producing the formulation is decreased, and the storage life is elongated to facilitate the administration by a patient and the preparation of the protein and vaccine drugs.
Type:
Application
Filed:
April 30, 2005
Publication date:
April 26, 2007
Applicant:
Quantum Hi-Tech (Beijing) Research Institute
Inventors:
Hewei Li, Hongfei Wang, Mingzhou Wang, Linyuan Wang