Patents Assigned to QUANTUMDX GROUP LIMITED
  • Patent number: 10792640
    Abstract: A sorbent material is disclosed for the one-step separation of bio-macromolecules in a single pass extraction of DNA from complex mixtures of molecules and chemicals. In one embodiment, the sorbent material comprises a silanized material at least partially coated or formed with a polymer selected from the group consisting of a poly(aryl methacrylate), a poly(aryl acrylate), a poly(heteroaryl methacrylate, a poly(heteroaryl acrylate) and a copolymer thereof.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: October 6, 2020
    Assignee: QUANTUMDX GROUP LIMITED
    Inventors: Jonathan James O'Halloran, Joseph H. Hedley, Sam Whitehouse, Marc Flanagan, John Tyson, Rachael Dixon, Sam Bhatt, Emily Crozier, Chris Howell
  • Patent number: 10759824
    Abstract: Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: September 1, 2020
    Assignee: QUANTUMDX GROUP LIMITED
    Inventors: Jonathan O'Halloran, Joseph H. Hedley
  • Patent number: 10710075
    Abstract: Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: July 14, 2020
    Assignee: QUANTUMDX GROUP LIMITED
    Inventors: Jonathan O'Halloran, Heather Murton, Stephen Osborne, Eduardo Boada, Jonathan Salmon
  • Publication number: 20190176151
    Abstract: Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.
    Type: Application
    Filed: June 20, 2017
    Publication date: June 13, 2019
    Applicant: QUANTUMDX GROUP LIMITED
    Inventors: Jonathan O'HALLORAN, Heather MURTON, Stephen OSBORNE, Eduardo BOADA, Jonathan SALMON
  • Patent number: 10273261
    Abstract: Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.
    Type: Grant
    Filed: January 3, 2017
    Date of Patent: April 30, 2019
    Assignee: QUANTUMDX GROUP LIMITED
    Inventors: Jonathan J. O'Halloran, Joseph H. Hedley
  • Patent number: 9938573
    Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of target nucleic acid (DNA, RNA, cDNA, etc) molecules.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: April 10, 2018
    Assignee: QUANTUMDX GROUP LIMITED
    Inventor: Jonathan O'Halloran
  • Publication number: 20170282154
    Abstract: A sorbent material is disclosed for the one-step separation of bio-macromolecules in a single pass extraction of DNA from complex mixtures of molecules and chemicals. In one embodiment, the sorbent material comprises a silanized material at least partially coated or formed with a polymer selected from the group consisting of a poly(aryl methacrylate), a poly(aryl acrylate), a poly(heteroaryl methacrylate, a poly(heteroaryl acrylate) and a copolymer thereof.
    Type: Application
    Filed: September 10, 2015
    Publication date: October 5, 2017
    Applicant: QuantuMDx Group Limited
    Inventors: Jonathan James O'HALLORAN, Joseph H. HEDLEY, Sam WHITEHOUSE, Marc FLANAGAN, John TYSON, Rachael DIXON, Sam BHATT, Emily CROZIER, Chris HOWELL
  • Patent number: 9605302
    Abstract: Embodiments of the present invention relate generally to strategies and methods of amplifying short target sequences and removing flanking sequences from target nucleic acids to remove background signal when detecting hybridizations events using sensitive detection biosensors, such as biosensors based on nanowires, carbon nanotubes, nanopores etc, that may be capable of detecting molecules at small molar concentrations (fM and less), or even at the single molecule level. Furthermore, by cropping and therefore standardizing the size of the target sequences to be detected, when detecting many target sequences in an array, the signals across each biosensor can be compared and the hybridization conditions standardized easily.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: March 28, 2017
    Assignee: QuantuMDx Group Limited
    Inventor: Jonathan O'Halloran
  • Patent number: 9410196
    Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of target nucleic acid (DNA, RNA, cDNA, etc) molecules.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: August 9, 2016
    Assignee: QUANTUMDX GROUP LIMITED
    Inventor: Jonathan O'Halloran
  • Publication number: 20150276709
    Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of long individual polynucleotide molecules.
    Type: Application
    Filed: August 5, 2013
    Publication date: October 1, 2015
    Applicant: QuantuMDx Group Limited
    Inventors: Jonathan O'Halloran, Christopher Adams, Joseph H. Hedley, Sam Whitehouse
  • Publication number: 20140206562
    Abstract: Fabrication of a microfluidic multi-temperature reaction device (MMR) and the design and fabrication of the equipment to drive various molecular biological methods on the device are provided. The device can be applicable, for example, to nucleic acid (DNA, RNA, cDNA, etc) amplification, cell lysis, reverse transcription and other enzymatic temperature sensitive and also temperature cycling reactions.
    Type: Application
    Filed: January 20, 2014
    Publication date: July 24, 2014
    Applicant: QUANTUMDX GROUP LIMITED
    Inventors: JOHN EDWARD MCCORMACK, ELAINE HARRINGTON WARBURTON, JONATHAN JAMES O'HALLORAN, MATTHEW DANIEL SOLOMON, DAVID JAMES BRIGGS, MINDY LEE ANDRE, MATTHIAS SCHUENEMANN
  • Publication number: 20140179909
    Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the extraction and fractionation of DNA molecules, from whole or lysed samples, in a single flow-through device.
    Type: Application
    Filed: November 30, 2011
    Publication date: June 26, 2014
    Applicant: QUANTUMDX GROUP LIMITED
    Inventors: Jonathan James O'Halloran, Elaine Harrington Warburton, Matthew Daniel Solomon, John Edward McCormack, Matthias Schuenemann, David James Briggs, Mindy Lee Andre
  • Publication number: 20110294685
    Abstract: Embodiments of the present invention relate generally to strategies and methods of amplifying short target sequences and removing flanking sequences from target nucleic acids to remove background signal when detecting hybridizations events using sensitive detection biosensors, such as biosensors based on nanowires, carbon nanotubes, nanopores etc, that may be capable of detecting molecules at small molar concentrations (fM and less), or even at the single molecule level. Furthermore, by cropping and therefore standardizing the size of the target sequences to be detected, when detecting many target sequences in an array, the signals across each biosensor can be compared and the hybridization conditions standardized easily.
    Type: Application
    Filed: September 3, 2009
    Publication date: December 1, 2011
    Applicant: QUANTUMDX GROUP LIMITED
    Inventor: Jonathan O'Halloran
  • Publication number: 20110165572
    Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of target nucleic acid (DNA, RNA, cDNA, etc) molecules.
    Type: Application
    Filed: September 3, 2009
    Publication date: July 7, 2011
    Applicant: QUANTUMDX GROUP LIMITED
    Inventor: Jonathan O'Halloran
  • Publication number: 20110165563
    Abstract: Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.
    Type: Application
    Filed: September 3, 2009
    Publication date: July 7, 2011
    Applicant: QUANTUMDX GROUP LIMITED
    Inventor: Jonathan O'Halloran