Patents Assigned to QUANTUMDX GROUP LIMITED
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Patent number: 11850593Abstract: Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.Type: GrantFiled: June 12, 2020Date of Patent: December 26, 2023Assignee: QUANTUMDX GROUP LIMITEDInventors: Jonathan O'Halloran, Heather Murton, Stephen Osborne, Eduardo Boada, Jonathan Salmon
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Patent number: 11596944Abstract: A microfluidics device has one or more bubble diversion regions. Problems associated with the generation of air bubbles are avoided in a microfluidics device such as a cartridge, for use with a point of care (POC) diagnostics device, the cartridge being able to carry out downstream processing such as polymerase chain reaction (PCR) and/or nucleic acid capture. The bubble diversion region has a lower flow resistance than the flow resistance of an area of interest.Type: GrantFiled: October 15, 2018Date of Patent: March 7, 2023Assignee: QUANTUMDX GROUP LIMITEDInventors: Hojjat Madadi, Thomas Michael Willshare, Jonathan O'Halloran, Philip Thomas Scully, Paul Marshall, Eduardo Boada
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Patent number: 11180523Abstract: Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.Type: GrantFiled: April 26, 2019Date of Patent: November 23, 2021Assignee: QUANTUMDX GROUP LIMITEDInventors: Jonathan J. O'Halloran, Joseph H. Hedley
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Patent number: 10792640Abstract: A sorbent material is disclosed for the one-step separation of bio-macromolecules in a single pass extraction of DNA from complex mixtures of molecules and chemicals. In one embodiment, the sorbent material comprises a silanized material at least partially coated or formed with a polymer selected from the group consisting of a poly(aryl methacrylate), a poly(aryl acrylate), a poly(heteroaryl methacrylate, a poly(heteroaryl acrylate) and a copolymer thereof.Type: GrantFiled: September 10, 2015Date of Patent: October 6, 2020Assignee: QUANTUMDX GROUP LIMITEDInventors: Jonathan James O'Halloran, Joseph H. Hedley, Sam Whitehouse, Marc Flanagan, John Tyson, Rachael Dixon, Sam Bhatt, Emily Crozier, Chris Howell
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Patent number: 10759824Abstract: Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.Type: GrantFiled: January 4, 2016Date of Patent: September 1, 2020Assignee: QUANTUMDX GROUP LIMITEDInventors: Jonathan O'Halloran, Joseph H. Hedley
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Patent number: 10710075Abstract: Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.Type: GrantFiled: June 20, 2017Date of Patent: July 14, 2020Assignee: QUANTUMDX GROUP LIMITEDInventors: Jonathan O'Halloran, Heather Murton, Stephen Osborne, Eduardo Boada, Jonathan Salmon
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Publication number: 20190176151Abstract: Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.Type: ApplicationFiled: June 20, 2017Publication date: June 13, 2019Applicant: QUANTUMDX GROUP LIMITEDInventors: Jonathan O'HALLORAN, Heather MURTON, Stephen OSBORNE, Eduardo BOADA, Jonathan SALMON
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Patent number: 10273261Abstract: Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.Type: GrantFiled: January 3, 2017Date of Patent: April 30, 2019Assignee: QUANTUMDX GROUP LIMITEDInventors: Jonathan J. O'Halloran, Joseph H. Hedley
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Patent number: 9938573Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of target nucleic acid (DNA, RNA, cDNA, etc) molecules.Type: GrantFiled: August 4, 2016Date of Patent: April 10, 2018Assignee: QUANTUMDX GROUP LIMITEDInventor: Jonathan O'Halloran
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Publication number: 20170282154Abstract: A sorbent material is disclosed for the one-step separation of bio-macromolecules in a single pass extraction of DNA from complex mixtures of molecules and chemicals. In one embodiment, the sorbent material comprises a silanized material at least partially coated or formed with a polymer selected from the group consisting of a poly(aryl methacrylate), a poly(aryl acrylate), a poly(heteroaryl methacrylate, a poly(heteroaryl acrylate) and a copolymer thereof.Type: ApplicationFiled: September 10, 2015Publication date: October 5, 2017Applicant: QuantuMDx Group LimitedInventors: Jonathan James O'HALLORAN, Joseph H. HEDLEY, Sam WHITEHOUSE, Marc FLANAGAN, John TYSON, Rachael DIXON, Sam BHATT, Emily CROZIER, Chris HOWELL
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Patent number: 9605302Abstract: Embodiments of the present invention relate generally to strategies and methods of amplifying short target sequences and removing flanking sequences from target nucleic acids to remove background signal when detecting hybridizations events using sensitive detection biosensors, such as biosensors based on nanowires, carbon nanotubes, nanopores etc, that may be capable of detecting molecules at small molar concentrations (fM and less), or even at the single molecule level. Furthermore, by cropping and therefore standardizing the size of the target sequences to be detected, when detecting many target sequences in an array, the signals across each biosensor can be compared and the hybridization conditions standardized easily.Type: GrantFiled: September 3, 2009Date of Patent: March 28, 2017Assignee: QuantuMDx Group LimitedInventor: Jonathan O'Halloran
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Patent number: 9410196Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of target nucleic acid (DNA, RNA, cDNA, etc) molecules.Type: GrantFiled: September 3, 2009Date of Patent: August 9, 2016Assignee: QUANTUMDX GROUP LIMITEDInventor: Jonathan O'Halloran
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Publication number: 20150276709Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of long individual polynucleotide molecules.Type: ApplicationFiled: August 5, 2013Publication date: October 1, 2015Applicant: QuantuMDx Group LimitedInventors: Jonathan O'Halloran, Christopher Adams, Joseph H. Hedley, Sam Whitehouse
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Publication number: 20140206562Abstract: Fabrication of a microfluidic multi-temperature reaction device (MMR) and the design and fabrication of the equipment to drive various molecular biological methods on the device are provided. The device can be applicable, for example, to nucleic acid (DNA, RNA, cDNA, etc) amplification, cell lysis, reverse transcription and other enzymatic temperature sensitive and also temperature cycling reactions.Type: ApplicationFiled: January 20, 2014Publication date: July 24, 2014Applicant: QUANTUMDX GROUP LIMITEDInventors: JOHN EDWARD MCCORMACK, ELAINE HARRINGTON WARBURTON, JONATHAN JAMES O'HALLORAN, MATTHEW DANIEL SOLOMON, DAVID JAMES BRIGGS, MINDY LEE ANDRE, MATTHIAS SCHUENEMANN
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Publication number: 20140179909Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the extraction and fractionation of DNA molecules, from whole or lysed samples, in a single flow-through device.Type: ApplicationFiled: November 30, 2011Publication date: June 26, 2014Applicant: QUANTUMDX GROUP LIMITEDInventors: Jonathan James O'Halloran, Elaine Harrington Warburton, Matthew Daniel Solomon, John Edward McCormack, Matthias Schuenemann, David James Briggs, Mindy Lee Andre
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Publication number: 20110294685Abstract: Embodiments of the present invention relate generally to strategies and methods of amplifying short target sequences and removing flanking sequences from target nucleic acids to remove background signal when detecting hybridizations events using sensitive detection biosensors, such as biosensors based on nanowires, carbon nanotubes, nanopores etc, that may be capable of detecting molecules at small molar concentrations (fM and less), or even at the single molecule level. Furthermore, by cropping and therefore standardizing the size of the target sequences to be detected, when detecting many target sequences in an array, the signals across each biosensor can be compared and the hybridization conditions standardized easily.Type: ApplicationFiled: September 3, 2009Publication date: December 1, 2011Applicant: QUANTUMDX GROUP LIMITEDInventor: Jonathan O'Halloran
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Publication number: 20110165572Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of target nucleic acid (DNA, RNA, cDNA, etc) molecules.Type: ApplicationFiled: September 3, 2009Publication date: July 7, 2011Applicant: QUANTUMDX GROUP LIMITEDInventor: Jonathan O'Halloran
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Publication number: 20110165563Abstract: Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.Type: ApplicationFiled: September 3, 2009Publication date: July 7, 2011Applicant: QUANTUMDX GROUP LIMITEDInventor: Jonathan O'Halloran