Patents Assigned to Queen's University at Kingston
  • Patent number: 11197931
    Abstract: The invention provides liquid injectable copolymers of TMC and HTMC that are degradable in vivo. Degradation can be tailored by adjusting the amount of HTMC in the copolymer, the initial molecular weight of the copolymer, and the characteristics of the initiator used in its preparation. Specifically, the degradation rate increases as the amount of HTMC incorporated into the copolymer increases, as the molecular weight of the copolymer decreases, and as the hydrophobicity of the initiator decreases. Moreover, the degradation yields products such as glycerol and carbon dioxide that are non-toxic in vivo, and which will not cause a substantive change in tissue pH upon implantation in vivo. The copolymers may be used in applications such as drug delivery and as coatings.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: December 14, 2021
    Assignee: Queen's University at Kingston
    Inventors: Sara Mohajeri, Brian G. Amsden, Fei Chen
  • Patent number: 11168064
    Abstract: The present invention relates to the preparation of compounds of Formula I, including thapsigargin, nortrilobolide and 8-O-debutanoyl-thapsigargin from commercially available (R)-(?)-carvone via synthetic intermediate compound of formula 12 by pinacol coupling and in situ lactonization.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: November 9, 2021
    Assignee: Queen's University at Kingston
    Inventors: P. Andrew Evans, Dezhi Chen
  • Publication number: 20210323844
    Abstract: A forward osmosis system is disclosed which use a polymer switchable between a neutral form and an ionized form. The switchable polymer has a higher osmotic pressure at the ionized form than the neutral form, the ratio between the former and the latter is ?2. There is also disclosed a method for treating the polymer such that the ratio is improved. Use of polymers for forward osmosis is also disclosed.
    Type: Application
    Filed: August 23, 2019
    Publication date: October 21, 2021
    Applicants: Queen's University at Kingston, Forward Water Technologies
    Inventors: Philip G. Jessop, Michael Cunningham, Pascale Champagne, Sarah Ellis, Ryan Dykeman, Charles Honeyman, Amy Holland, Tobias Robert, Bhanu Mudraboyina
  • Patent number: 11131650
    Abstract: A method of facilitating ultrasonic analysis of a subject is provided. The method involves producing signals for causing a set of outgoing ultrasonic signals to be transmitted to the subject, wherein the set of outgoing ultrasonic signals is defined at least in part by a variable imaging parameter that varies over time in accordance with a variable imaging parameter function, the variable imaging parameter function represented or representable at least in part by a function characteristic, receiving signals representing a time dependent representation of the subject generated from a set of received ultrasonic signals scattered by the subject, determining at least one property representation of the subject based on the function characteristic and the time dependent representation of the subject, and producing signals representing the at least one property representation of the subject to facilitate analysis of the subject. Systems, non-transitory computer readable media, and other methods are also provided.
    Type: Grant
    Filed: March 18, 2021
    Date of Patent: September 28, 2021
    Assignees: The University of British Columbia, Queen's University at Kingston
    Inventors: Purang Abolmaesumi, Parvin Mousavi
  • Patent number: 11125638
    Abstract: Apparatus and methods for measuring force exerted by an object moving in a fluid or force of a moving fluid on a stationary object. Embodiments may be configured to measure power exerted by an object moving in a fluid. At least one sensor disposed on the object outputs at least one sensor signal corresponding to a pressure differential between first and second surfaces of the object. Data derived from one or more sensor signals may be processed according to a model to output a measure of the force and/or power of the object moving in the fluid or the force of the moving fluid on the stationary object, as a function of time. Embodiments may be configured for applications such as providing feedback for control of actuators in electromechanical systems for liquid or gaseous media, and providing performance metrics during water sports, such as swimming and paddling.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: September 21, 2021
    Assignee: Queen's University at Kingston
    Inventors: David Rival, Scott Fitzpatrick, Louis Burelle
  • Patent number: 11108330
    Abstract: In an AC-DC converter having a primary side control circuit, auxiliary power for the control circuit is derived from the converter secondary side through an isolated DC-DC converter. The circuits and methods solve the problem of supplying primary side auxiliary power during light load or no load operation of the AC-DC power converter. Since the output voltage of the AC-DC converter is normally regulated at a fixed level, the auxiliary voltage that is generated by the isolated DC converter is regulated. In some cases the isolated DC-DC converter may not need to be regulated, which simplifies the design and reduces overall cost.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: August 31, 2021
    Assignee: Queen's University at Kingston
    Inventors: Yang Chen, Yan-Fei Liu
  • Patent number: 11045557
    Abstract: Disclosed are novel gene therapy constructs containing both HEXA and HEXB genes to treat GM2 gangliosidoses, including Sandhoff disease and Tay-Sach's disease. Also described are co-treatments using chaperone and anti-inflammatory agents to enhance the effects of gene therapy.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: June 29, 2021
    Assignees: Queen's University at Kingston, Kingston Health Sciences Centre
    Inventor: Jagdeep Singh Walia
  • Patent number: 11026750
    Abstract: An apparatus and method for surgical tracking comprises an imaging device that generates an image of a tissue volume; an electromagnetic (EM) sensor that creates a reference frame for EM tracking in three dimensions; at least one EM sensor adapted to be attached to the tissue to track local deformation and movement of the tissue volume; a processor that registers the image with the EM-tracked tissue volume and surgical tool in real time, and produces an output; and a feedback device that provides feedback about the location of the surgical tool relative to the tissue volume, based on the processor output. Embodiments are particularly useful in soft tissue, such as breast, where deformation before and during a procedure such as tumor resection complicate tracking of the tissue volume and a surgical tool.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: June 8, 2021
    Assignees: Queen's University at Kingston, Kingston Health Sciences Centre
    Inventors: Gabor Fichtinger, Tamas Ungi, John F. Rudan, Andras Lasso, C. Jay Engel, Gabrielle Gauvin, Caitlin Yeo
  • Patent number: 11008291
    Abstract: Deposition of carbene monolayers that excluded starting anions, such as iodide ions, has been achieved. Anions such as iodide are a typical contaminant in carbene hydrogen carbonate salts when synthesized using the state-of-the-art method. A method is described for eliminating substantially all starting anion (e.g., iodide) contamination from the monolayer. Air stable, purified carbenes precursors were used to deposit an intact monolayer on the surface of some industrially relevant metals. The monolayer's ability to protect these metals against, for example, oxidation has been demonstrated.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: May 18, 2021
    Assignee: Queen's University at Kingston
    Inventors: Cathleen M. Crudden, J. Hugh Horton, Mina Raafat Ryad Narouz, Joseph Daniel Padmos
  • Patent number: 11007015
    Abstract: Provided are apparatus and methods for tracking a volume of interest in three dimensions in real time, using fewer than 6 DOF tracking information together with an external 6 DOE coordinate system. The apparatus and methods described herein provide more accurate, smaller, and less expensive tracking systems than prior approaches based on full 6 DOF tracking comprising translation and full orientation information. Embodiments may be used in applications such as surgical navigation, gaming, robotics, motion capture, and training.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: May 18, 2021
    Assignee: Queen's University at Kingston
    Inventors: Thomas Vaughan, Andras Lasso, Gabor Fichtinger, Tamas Ungi
  • Publication number: 20210115522
    Abstract: Methods, probe sets, kits, and compositions for gene deletion assays are disclosed. In some embodiments, the methods relate to preparing probes for a deletion assay, performing a deletion assay, or optimizing a deletion assay. In some embodiments, the methods and probe sets can provide reduced artifactual deletion frequency, for example, when analyzing samples subject to truncation artifacts. In some embodiments, the methods and probe sets can distinguish between small and large deletions.
    Type: Application
    Filed: December 16, 2020
    Publication date: April 22, 2021
    Applicants: QUEEN'S UNIVERSITY AT KINGSTON, KINGSTON HEALTH SCIENCES CENTRE
    Inventors: Jeremy A. Squire, Maisa Yoshimoto
  • Patent number: 10944329
    Abstract: Resonant converters may be operated according to selected working modes to achieve voltage doubler or non-voltage doubler functions. Embodiments may be based on two-phase resonant converters. Embodiments may implement primary side switching, secondary side switching, or both, to achieve the selected working modes and voltage doubler and non-voltage doubler function. Embodiments are suitable for applications requiring wide input and output voltage ranges, such as low-voltage charging circuits for personal electronic devices, and high voltage charging circuits for electric vehicles.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: March 9, 2021
    Assignee: Queen's University at Kingston
    Inventors: Hongliang Wang, Yang Chen, Yan-Fei Liu
  • Patent number: 10922173
    Abstract: Described are fountain code constructs that solve multiple problems in distributed storage systems by providing systematic encoding, reduced repair locality, reduced encoding/decoding complexity, and enhanced reliability. Embodiments are suitable for the storage of large files and exhibit performance superior to existing codes, and demonstrate reduced implementation complexity and enhanced symbol repair locality.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: February 16, 2021
    Assignee: Queen's University at Kingston
    Inventors: Toritseju Okpotse, Shahram Yousefi
  • Patent number: 10899936
    Abstract: Polyurethane-based and epoxy-based coating compositions are described that provide coatings and adhesives that are clear, amphiphobic and durable. Both water and hexadecane readily slide off these surfaces without leaving a residue. Coatings with thicknesses ranging from about 10 nm to about 10 ?m exhibited excellent transmittance properties. Such films exhibited durability against abrasion, ink-resistance, anti-graffiti, anti-fingerprint, and strong adhesion to glass surfaces. The coatings are applicable to electronic devices, fabrics, glass, etc. to prepare optically clear, stain-resistant, and smudge-resistant surfaces.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: January 26, 2021
    Assignee: QUEEN'S UNIVERSITY AT KINGSTON
    Inventors: Heng Hu, Guojun Liu, Muhammad Rabnawaz
  • Patent number: 10901226
    Abstract: A capillary comprises a capillary channel, an inner layer, and an outer layer, wherein the inner and outer layers comprise different silica materials. An axicon lens formed on a facet end of the capillary channel has a selected geometry, such that the inner layer has an axicon angle ? and a post angle ?. The inner layer may be fused silica and the outer layer may be borosilicate glass. The post angle ? is determined in part by an etch rate constant of the borosilicate glass and an etch rate constant of the fused silica in at least one etching reagent. Embodiments may comprise at least two capillary channels, and an axicon lens formed on a facet end of each of the at least two capillary channels. The capillary may be used as an electrospray emitter, optionally with light simultaneously while generating an electrospray.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: January 26, 2021
    Assignee: Queen's University at Kingston
    Inventors: Richard Oleschuk, Hans-Peter Loock, Kyle Bachus
  • Patent number: 10874991
    Abstract: A composite material is described that is an effective filter to separate oil from an oil and water emulsion or other mixtures of oil and water. The composite material has a permeable substrate, such as fabric, that is coated with a selectively-permeable coating. The composite material allows only oil to pass through, while water is prevented from passing through. The composite material has two main components, a hydrophobic component and an emulsion-destabilizing component.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: December 29, 2020
    Assignee: Queen's University at Kingston
    Inventors: Guojun Liu, Yu Wang, Zijie Wang, Shuaishuai Huang
  • Patent number: 10874634
    Abstract: Compounds described herein are inhibitors of retinoic acid inducible P450 (CYP26) enzymes, and are useful for treating diseases that are responsive to retinoids. Certain compounds have retinoid activity, are resistant to CYP26-mediated catabolism, and are used for treating diseases that are responsive to retinoids.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: December 29, 2020
    Assignee: Queen's University at Kingston
    Inventors: Donald Andrew Cameron, Martin Petkovich, Toni Kristian Rantanen, Victor Snieckus, Johnathan Board, Suneel Singh, Ashishkumar Jayantilal Maheta
  • Patent number: 10877136
    Abstract: This invention relates to a method of analyzing an ultrasound signal. The method comprises obtaining a time series of sequential data frames associated with an ultrasound signal reflected from and/or backscattered from a fixed location of a material under investigation, each data frame comprising a plurality of samples of the ultrasound signal, and subjecting to an analysis a sequence of one or more samples of the ultrasound signal, or a sequence of at least one parameter derived from one or more samples of the ultrasound signal, wherein a result of the analysis is related to one or properties or characteristics of the material. In one embodiment the method may be used for detecting, diagnosing, and/or assessing cancer and/or abnormalities in biological tissue.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: December 29, 2020
    Assignee: Queen's University at Kingston
    Inventors: Mehdi Moradi, Purang Abolmaesumi, Parvin Mousavi, Eric Sauerbrei, Robert Siemens, Phillip Isotalo
  • Patent number: 10772502
    Abstract: The invention provides devices and methods for non-invasive monitoring and measuring of intraocular pressure (IOP) of a subject. Embodiments include a lens that is adapted to fit on the subject's eye, a microstructure disposed in or on the lens, the microstructure having at least one feature that exhibits a change in shape and/or geometry and/or position on the lens in response to a change in curvature of the lens. When the curvature of the lens changes in response to a change in IOP, a corresponding change in shape and/or geometry and/or position of the feature may be used to determine the change in IOP. The change in the feature is detectable in digital images of the lens taken with a mobile electronic device such as a smartphone.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: September 15, 2020
    Assignees: Queen's University at Kingston, Kingston Health Sciences Centre
    Inventors: Yong Jun Lai, Kong Ying Xie, Robert James Campbell
  • Patent number: 10676190
    Abstract: An autorotating unmanned aerial vehicle (UAV) has a data acquisition system and a rotor assembly including a hub that couples the rotor assembly to the UAV. Although not limited thereto, the UAV is suitable for collecting data about the inside of a cavity. The data acquisition system includes a processor and one or more sensors that obtain data about motion of the UAV and at least one parameter of the cavity as the UAV descends though the cavity. Features of the cavity may be mapped by generating a 3D point cloud from the data. The cavity may be natural or man-made, such as a mine.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: June 9, 2020
    Assignee: Queen's University at Kingston
    Inventors: Jordan Mitchell, Joshua Marshall