Patents Assigned to Queen's University at Kingston
  • Decellularized adipose tissue
    Patent number: 9034386
    Abstract: This invention provides a method for decellularizing adipose tissue, comprising subjecting the adipose tissue to one or more incubations in an enzymatic digestion solution containing one or more enzymes, and one or more solvent extractions, wherein decellularized adipose tissue comprising an extracellular matrix with well-preserved three-dimensional structure is obtained. The invention also provides a decellularized adipose tissue comprising an extracellular matrix with well-preserved three-dimensional architecture, and bioscaffolds, microcarrier beads, and coatings comprising the decellularized adipose tissue.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: May 19, 2015
    Assignee: Queen's University at Kingston
    Inventor: Lauren E. Flynn
  • C-arm rotation encoding methods and apparatus
    Patent number: 9008279
    Abstract: This invention provides a method for estimating C-ARM fluoroscope rotation pose, and related programmed media and kits. In one embodiment the method includes measuring an angle of the C-arm using an accelerometer affixed to the C-arm, wherein the accelerometer is not moving during the measurement. The method includes generating angle correction equations based on differences between C-arm poses and corresponding accelerometer angles, and optionally generating structural compensation equations to compensate for structural flexion or deformation of the C-arm.
    Type: Grant
    Filed: June 22, 2011
    Date of Patent: April 14, 2015
    Assignee: Queen's University at Kingston
    Inventors: Victor Grzeda, Gabor Fichtinger
  • Method and Apparatus for Communication Between Humans and Devices
    Publication number: 20150042555
    Abstract: This invention relates to methods and apparatus for improving communications between humans and devices. The invention provides a method of modulating operation of a device, comprising: providing an attentive user interface for obtaining information about an attentive state of a user; and modulating operation of a device on the basis of the obtained information, wherein the operation that is modulated is initiated by the device. Preferably, the information about the user's attentive state is eye contact of the user with the device that is sensed by the attentive user interface.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 12, 2015
    Applicant: Queen's University at Kingston
    Inventors: Roel Vertegaal, Jeffrey S. Shell
  • Multiple wavelength cavity ring-down spectroscopy
    Patent number: 8941828
    Abstract: Described are methods for multi-wavelength cavity ring-down spectroscopy; comprising simultaneously and continuously irradiating an optical cavity with light at two or more different wavelengths, each light being intensity-modulated at a different modulation frequency, detecting the light of two or more wavelengths after the light has traveled through the optical cavity; measuring an optical loss of each detected light; and determining a characteristic of the optical cavity from the optical loss of each detected light. Also described are apparatus and systems for multi-wavelength cavity ring-down spectroscopy.
    Type: Grant
    Filed: February 22, 2012
    Date of Patent: January 27, 2015
    Assignee: Queen's University at Kingston
    Inventors: Hans-Peter Loock, Helen Waechter
  • METHOD FOR TREATMENT OF DISORDERS OF THE GASTROINTESTINAL SYSTEM
    Publication number: 20140363397
    Abstract: There are provided novel synthetic stool preparations comprising bacteria isolated from a fecal sample from a healthy donor. The synthetic stool preparations are used for treating disorders of the gastrointestinal tract, including dysbiosis, Clostridium difficile infection and recurrent Clostridium difficile infection, prevention of recurrence of Clostridium difficile infection, treatment of Crohn's disease, ulcerative colitis, irritable bowel syndrome, inflammatory bowel disease, and diverticular disease, and treatment of food poisoning such as salmonella. Methods of preparation and methods of use of the synthetic stool preparations are also provided.
    Type: Application
    Filed: September 14, 2012
    Publication date: December 11, 2014
    Applicants: QUEEN'S UNIVERSITY AT KINGSTON, UNIVERSITY OF GUELPH, KINGSTON GENERAL HOSPITAL
    Inventors: Emma Allen-Vercoe, Elaine Olga Petrof
  • Switchable hydrophilicity solvents and methods of use thereof
    Patent number: 8900444
    Abstract: A solvent that reversibly converts from a hydrophobic liquid form to hydrophilic liquid form upon contact with water and a selected trigger, e.g., contact with CO2, is described. The hydrophilic liquid form is readily converted back to the hydrophobic liquid form and water. The hydrophobic liquid is an amidine or amine. The hydrophilic liquid form comprises an amidinium salt or an ammonium salt.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: December 2, 2014
    Assignees: Queen's University at Kingston, GreenCentre Canada
    Inventors: Philip G. Jessop, Lam N. Phan, Andrew J. Carrier, Rui Resendes, Dominik Wechsler
  • Patient-Specific Surgical Guidance Tool and Method of Use
    Publication number: 20140343403
    Abstract: Presented is a preoperatively designed guidance tool for intraoperative use during bone or joint surgery wherein the guidance tool is specific to the anatomy of the patient being treated. The guidance tool comprises a body portion, a mating surface provided on the body portion for positioning the guidance tool on a corresponding registration surface of a patient's anatomy. The guidance tool further comprises at least one guide mechanism provided on the body portion for guiding a medical instrument at one or more preoperatively defined trajectories relative to a patient's anatomy. In the event of misalignment, the at least one guide mechanism is adjustable to alter the one or more preoperatively defined trajectories if necessary during intraoperative use. Also presented is a preoperative process for designing the guidance tool.
    Type: Application
    Filed: May 14, 2013
    Publication date: November 20, 2014
    Applicant: Queen's University at Kingston
    Inventor: Queen's University at Kingston
  • System and method for determining the envelope of a modulated signal
    Patent number: 8867930
    Abstract: Systems and methods for determining the envelope of a modulated signal using high bandwidth and low bandwidth samples of a hybrid signal. The hybrid signal is obtained by mixing the modulated signal with its carrier signal. The systems and methods of the present disclosure may be suitable for equivalent-time or real-time oscilloscopes.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: October 21, 2014
    Assignee: Queen's University at Kingston
    Inventors: David J. Krause, John C. Cartledge
  • DETECTION OF BIOLOGICAL MOLECULES BY DIFFERENTIAL PARTITIONING OF ENZYME SUBSTRATES AND PRODUCTS
    Publication number: 20140295403
    Abstract: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples.
    Type: Application
    Filed: November 18, 2013
    Publication date: October 2, 2014
    Applicant: QUEEN'S UNIVERSITY AT KINGSTON
    Inventors: R. Stephen BROWN, Samir P. TABASH, Igor S. KOZIN, Eric J.P. MARCOTTE, Arthur N. LEY, Kevin R. HALL, Moe HUSSAIN, Peter V. HODSON, Sr., Parveen AKHTAR, Raymond J. BOWERS, Robin A. WYNNE-EDWARDS, John G. ST. MARSEILLE
  • Device and Method for Image-Guided Surgery
    Publication number: 20140276001
    Abstract: In one aspect the invention provides a reference device that enhances image-guided surgical interventions. The reference device is tracked by the imaging system and used to verify the accuracy of the intervention tool placement before and during the intervention. The reference device holds a reference sensor in a position aligned with patient anatomy, so that images are displayed in the correct orientation to the operator, aiding in target recognition and better navigation. Also provided are methods using the reference device and programmed computer media for implementing at least a part of the methods.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: Queen's University at Kingston
    Inventors: Tamas Ungi, Andras Lasso, Gabor Fichtinger
  • METHODS AND KITS FOR DIAGNOSING, PROGNOSTICATING RISK/OUTCOME, AND/OR TREATING BREAST CANCER
    Publication number: 20140272957
    Abstract: Methods and kits for diagnosing, prognosticating risk of, and selecting and/or administering a therapy for breast cancer based upon detection of methylated glucocorticoid receptor gene or measurement of glucocorticoid receptor and BRCA1 gene expression levels are provided.
    Type: Application
    Filed: June 2, 2014
    Publication date: September 18, 2014
    Applicant: Queen's University at Kingston
    Inventors: Christopher Robert Mueller, Kirsten A. Nesset
  • Ripple Cancellation Converter with High Power Factor
    Publication number: 20140252973
    Abstract: Provided are circuits and methods for use with a power supply that provides a main output including a main DC voltage having a first AC voltage ripple, or a main DC current having a first AC current ripple. A ripple cancellation converter provides a second AC voltage ripple connected in series with the main output, such that the first AC voltage ripple is substantially cancelled; or a second AC current ripple connected in parallel with the main output, such that the first AC current ripple is substantially cancelled. As a result, substantially ripple-free DC output power is provided.
    Type: Application
    Filed: October 17, 2012
    Publication date: September 11, 2014
    Applicant: Queen's University at Kingston
    Inventor: Yan-Fei Liu
  • Methods and systems for coherent imaging and feedback control for modification of materials
    Patent number: 8822875
    Abstract: Methods and systems are provided for using optical interferometry in the context of material modification processes such as surgical laser or welding applications. An imaging optical source that produces imaging light. A feedback controller controls at least one processing parameter of the material modification process based on an interferometry output generated using the imaging light. A method of processing interferograms is provided based on homodyne filtering. A method of generating a record of a material modification process using an interferometry output is provided.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: September 2, 2014
    Assignee: Queen's University at Kingston
    Inventors: Paul J. L. Webster, James M. Fraser, Victor X. D. Yang
  • SWITCHABLE HYDROPHILICITY SOLVENTS AND METHODS OF USE THEREOF
    Publication number: 20140235908
    Abstract: A solvent that reversibly converts from a hydrophobic liquid form to hydrophilic liquid form upon contact with water and a selected trigger, e.g., contact with CO2, is described. The hydrophilic liquid form is readily converted back to the hydrophobic liquid form and water. The hydrophobic liquid is an amidine or amine. The hydrophilic liquid form comprises an amidinium salt or an ammonium salt.
    Type: Application
    Filed: November 8, 2013
    Publication date: August 21, 2014
    Applicants: GreenCentre Canada, Queen's University at Kingston
    Inventors: Philip G. JESSOP, Lam N. Phan, Andrew J. Carrier, Rui Resendes, Dominik Wechsler
  • Robotic exoskeleton for limb movement
    Patent number: 8800366
    Abstract: This invention relates to a robotic exoskeleton comprising mechanical linkages that couple to one or more selected joints of a limb of a subject. The robotic exoskeleton may be provided with means for obtaining data respecting angular position, torque, and/or acceleration of at least one of the joints or the links of the mechanical linkages, and may be used for assessing, studying, diagnosing a deficit, and/or treating an impairment in sensorimotor function of a limb of a subject.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: August 12, 2014
    Assignee: Queen's University at Kingston
    Inventors: Stephen H. Scott, Ian E. Brown, Stephen J. Ball
  • Substituted Diarylamines and Use of Same as Antioxidants
    Publication number: 20140206585
    Abstract: A compound of Formula I, Formula IA, Formula IB, or Formula II, or an acid or base addition salt thereof, and use of these compounds as antioxidants. In one embodiment, a compound of Formula II, wherein each of X, Y, and Z are independently a carbon or nitrogen atom; R1 and R2 are each independently a hydrogen or an electron donating group, but are not both hydrogen, and wherein R1, and R2 are each bonded to a carbon atom in their own respective aryl ring.
    Type: Application
    Filed: June 4, 2012
    Publication date: July 24, 2014
    Applicants: UNIVERSITA DI BOLOGNA, Queen's University at Kingston
    Inventors: Derek A. Pratt, Jason J. Hanthorn, Luca Valgimigli
  • Biomass Pellet and Method of Producing Same
    Publication number: 20140183791
    Abstract: Described is a substantially spherical biomass pellet, comprising compressed particulate biomass including one or more of ligno-cellulosic material, recycling waste, and dewatered municipal solid waste, useful as a fuel. Also described are methods for producing such pellets using one or more of untorrefied biomass and torrefied biomass, and apparatus for producing such biomass pellets.
    Type: Application
    Filed: February 9, 2012
    Publication date: July 3, 2014
    Applicant: Queen's University at Kingston
    Inventors: William Andrew Duncan, Andrew Pollard, M. Hachimi Fellouah
  • ELECTROKINETICS-ASSISTED SENSOR
    Publication number: 20140166483
    Abstract: An electrokinetics-assisted sensor for sensing a target material. The sensor may include a microstructure deflectable in response to added mass on its body. The sensor may also include one or more features on or near the microstructure designed to generate an electric field giving rise to one or more electrokinetic effects to drive material towards the microstructure, when an electrical signal is applied to the feature(s). Presence of the target material on the body of the microstructure may cause a response in the microstructure, including a detectable change in deflection of the microstructure.
    Type: Application
    Filed: December 19, 2013
    Publication date: June 19, 2014
    Applicant: Queen's University at Kingston
    Inventors: Jacky CHOW, Matthew R. TOMKINS, Yong Jun LAI, Aristides DOCOSLIS
  • Compounds and Methods for Treating Cancer and Diseases of the Central Nervous System
    Publication number: 20140155445
    Abstract: Disclosed are compounds of the general formula (I): compositions comprising an effective amount of said compounds either alone or in combination with other chemotherapeutic agents, and methods useful for treating or preventing cancer and for inhibiting tumour tissue growth. These compounds attenuate the oxidative damage associated with increased heme-oxygenase activity and can reduce cell proliferation in transformed cells. In addition, the described compounds and compositions are useful as neuroprotectants and for treating or preventing neurodegenerative disorders and other diseases of the central nervous system.
    Type: Application
    Filed: September 18, 2013
    Publication date: June 5, 2014
    Applicants: QUEEN'S UNIVERSITY AT KINGSTON, Osta Biotechnologies Inc., The Sir Mortimer B. Davis - Jewish General Hospital
    Inventors: Ajay Gupta, Hyman M. Schipper, Moulay Alaoui-Jamali, Walter A. Szarek, Kanji Nakatsu, Jason Z. Vlahakis
  • Method and apparatus for assessing or detecting brain injury and neurological disorders
    Patent number: 8740794
    Abstract: A method and apparatus is provided for diagnosing, assessing, or detecting brain injury and/or a neurological disorder of a subject. Objects are presented to the subject over a range of locations within the subject's workspace such that the subject can interact with at least some of the presented objects using either the right or left limb, or portion thereof, of a pair of limbs. Position data and/or motion data and/or kinetic data of the left and right limbs or portions thereof with respect to a presented object are obtained, and a data set is acquired for a plurality of presented objects. The acquired data set provides information about brain injury and/or a neurological disorder in the subject.
    Type: Grant
    Filed: October 21, 2011
    Date of Patent: June 3, 2014
    Assignee: Queens' University at Kingston
    Inventor: Stephen H. Scott