Patents Assigned to Quest Diagnostics Investments Incorporated
  • Quantitation of insulin by tandem mass spectrometry of insulin B chain
    Patent number: 10436803
    Abstract: Methods are described for determining the amount of insulin in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying insulin in a biological sample utilizing purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: October 8, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Zhaohui Chen, Nigel Clarke
  • EML4-ALK translocations in lung cancer
    Patent number: 10435758
    Abstract: The present disclosure relates to methods for the diagnosis and evaluation of neoplastic disorders, particularly non-small cell lung cancer. Assays are described in which patient test samples are analyzed for the presence of one or more specific EML4-ALK fusion genes associated with neoplastic disorders.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: October 8, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Heather R. Sanders, Maher Albitar, Aurelia Meloni-Ehrig
  • Vitamin D metabolite determination utilizing mass spectrometry following derivatization
    Patent number: 10429398
    Abstract: The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: October 1, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel J. Clarke, Richard E Reitz
  • Mass spectrometry assay for congenital adrenal hyperplasia
    Patent number: 10429396
    Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: October 1, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Amit Ghoshal, Nigel J. Clarke, Mildred M. Goldman
  • Discriminating BRAF mutations
    Patent number: 10422008
    Abstract: Provided herein are methods for detecting and discriminating BRAF V600 mutations. Also provided herein are methods for diagnosis, prognosis, management, and treatment decisions of BRAF V600 mutation-related diseases or conditions.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: September 24, 2019
    Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventors: Amber C. Donahue, Yen-lin Peng
  • Circulating microRNA as a marker for hepatocellular carcinoma
    Patent number: 10422010
    Abstract: Provided herein are methods for the diagnosis, or management of liver diseases, e.g., hepatocellular carcinoma, using profiles of the miRNAs determined from cellular or acellular body fluids.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: September 24, 2019
    Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventors: Kevin Qu, Ke Zhang, Maher Albitar
  • Methods for detecting estrone by mass spectrometry
    Patent number: 10422804
    Abstract: Provided are methods for determining the amount of estrone in a sample using mass spectrometry. The methods generally involve ionizing estrone in a sample and detecting and quantifying the amount of the ion to determine the amount of estrone in the sample.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: September 24, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Mildred M. Goldman, Richard E. Reitz
  • Detection of methicillin-resistant in biological samples
    Patent number: 10407739
    Abstract: Disclosed are methods of identifying a methicillin-resistant Staphylococcus aureus (MRSA) in a sample wherein the methods involve detecting a S. aureus-specific nucleic acid sequence, mecA and mecC, in the sample. Kits for determining the presence of MRSA in a sample are also provided.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: September 10, 2019
    Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventors: Lakshmi Nair, Heather Vincent, Huong Mai, Michael Aye, Michelle Tabb, Maurice Exner
  • Detection of methicillin-resistant in biological samples
    Patent number: 10385408
    Abstract: Disclosed are methods of identifying a methicillin-resistant Staphylococcus aureus (MRSA) in a sample wherein the methods involve detecting a S. aureus-specific nucleic acid sequence, mecA and mecC, in the sample. Kits for determining the presence of MRSA in a sample are also provided.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: August 20, 2019
    Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventors: Lakshmi Nair, Heather Vincent, Huong Mai, Michelle Tabb, Maurice Exner
  • Statistical quality control of medical laboratory results
    Patent number: 10325067
    Abstract: Laboratory testing plays a significant and growing role in the delivery of medical services. Fresh analysis of past test results has led to discovery of previously unknown correlations between statistical properties of analyte values and parameters such as age, sex, and region. Observed values in patient populations have also newly been discovered to show both secular and regular periodic variations over time. Embodiments of the invention may use information about these correlations to improve quality control and other statistical analysis of patient samples by applying adjusted reference ranges to quality control methodologies, and providing a quality control grade for patient samples based on the adjusted reference ranges.
    Type: Grant
    Filed: December 31, 2012
    Date of Patent: June 18, 2019
    Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventor: Stephen Suffin
  • Monolithic column chromatography
    Patent number: 10317377
    Abstract: Provided herein are methods of liquid column chromatography in which preparative chromatography is performed in-line with analytical chromatography. In particular aspects a monolithic preparative column is used to purify an analyte of interest from a mixture of other substances by applying the mixture to the column, reversing the flow through the column to elute the analyte, which is applied to an analytical column provided in-line with the preparative column. In other aspects, a single monolithic column is used to perform both the preparative chromatography and analytical chromatography steps in succession. In another aspect, a chromatography system is provided to perform preparative and analytical chromatography using a single monolithic column.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: June 11, 2019
    Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventors: Nigel Clarke, Mildred M. Goldman
  • DETECTION OF VITAMINS A AND E BY TANDEM MASS SPECTROMETRY
    Publication number: 20190170774
    Abstract: Methods are described for measuring the amount of one or more of vitamin A, ?-tocopherol, and the combination of ?-tocopherol and ?-tocopherol in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying one or more of vitamin A, ?-tocopherol, and the combination of ?-tocopherol and ?-tocopherol in a sample.
    Type: Application
    Filed: February 8, 2019
    Publication date: June 6, 2019
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Sum CHAN, Qibo JIANG
  • Thyroglobulin quantitation by mass spectrometry
    Patent number: 10309971
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: June 4, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Yanni Zhang, Nigel J. Clarke, Richard E. Reitz
  • Magnetic separation of lipoproteins using dextran sulfate
    Patent number: 10308680
    Abstract: The invention provides apparatus and methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged-particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged-particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: June 4, 2019
    Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventors: Michael P. Caulfield, Jackie Liu, Dawn Shalhout, Zhihong Chen
  • C peptide detection by mass spectrometry
    Patent number: 10309972
    Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: June 4, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel Clarke, Zhaohui Chen
  • ANALYSIS OF AMINO ACIDS IN BODY FLUID BY LIQUID CHROMOTOGRAPHY-MASS SPECTROMETRY
    Publication number: 20190145983
    Abstract: This disclosure provides methods for quantifying individual amino acids in various bodily fluids obtained from a human patient. Also provided are reference ranges for normal amino acid levels in the various bodily fluids (e.g., blood plasma, urine, cerebrospinal fluid, and saliva) and for various age groups (e.g., neonates, infants, children, and adults).
    Type: Application
    Filed: January 7, 2019
    Publication date: May 16, 2019
    Applicant: Quest Diagnostics Investments Incorporated
    Inventor: Scott GOLDMAN
  • METHODS FOR CELL-FREE DNA EXTRACTION FOR NON-INVASIVE PRENATAL SCREENING
    Publication number: 20190127728
    Abstract: Provided herein are methods and systems for cell-free DNA extraction from liquid biological samples. The methods can be employed for determination of fetal DNA fraction and non-invasive prenatal screening of fetal aneuploidies and analyses of other types of cell-free DNA.
    Type: Application
    Filed: October 25, 2016
    Publication date: May 2, 2019
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Ben ANDERSON, Charles STROM, David TSAO, Yan LIU, Weimin SUN
  • Methods for detecting vitamin D metabolites by mass spectrometry
    Patent number: 10267810
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally directed to ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: April 23, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel J. Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz
  • Multiplex detection assay for influenza and RSV viruses
    Patent number: 10260113
    Abstract: The present invention generally relates to a molecular test of Influenza A, Influenza B, Respiratory Syncytial Virus A, and Respiratory Syncytial Virus B in order to identify patients with a viral infection. Accordingly methods and compositions are disclosed to determine the presence or absence of a viral pathogen in a sample containing one or more target nucleic acids from the M gene of Influenza A, Influenza B, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B.
    Type: Grant
    Filed: December 11, 2012
    Date of Patent: April 16, 2019
    Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventors: Jules Chen, Lilly I. Kong, Ming-Chou Lee, Fan Chen, Michelle M. Tabb, Michael Aye
  • Mass spectrometric determination of fatty acids
    Patent number: 10242852
    Abstract: The invention relates to the detection of fatty acids. In a particular aspect, the invention relates to methods for detecting very long chain fatty acids and branched chain fatty acids by mass spectrometry.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: March 26, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventor: Scott Goldman