Abstract: An image capturing and processing device to measure a fluorescence signal in tissue and image a surface of a body part. The device includes a fluorescence image sensor to capture a fluorescence image . The fluorescence image sensor captures time sequence of fluorescence images A peak frequency map unit determines a peak frequency map for an area of interest in the fluorescence images by analyzing the time sequence of fluorescence images. The analyzing includes: determining a time-dependent intensity curve, identifying peaks in the time-dependent intensity curve and determining one or more of a frequency of the identified peaks and a maximum high of the identified peaks, generating a graphic representation of one or more of the determined frequency and maximum high and including the same in the peak frequency map. The peak frequency map together with one or more of the visible light image and the fluorescence image are outputted.

Abstract: Computer based clinical decision support system (CDSS) and method for determining a classification of a lymphedema induced fluorescence pattern. The fluorescence image is determined from a measurement of a fluorescence signal in a tissue of a body part, to which a fluorescent agent 8 has been added. The CDSS including: an input interface through which the fluorescence image, which is specific to a patient, is provided as an input feature to an artificial intelligence (AI) model, one or more processors configured to, perform an inference operation in which the fluorescence image is applied to the AI model to generate the classification of a lymphedema induced fluorescence pattern, and a user interface (UI) through which the classification of the lymphedema induced fluorescence pattern is communicated to a user.

Abstract: An image capturing and processing device configured to measure a fluorescence signal in a tissue of a body part, to which a fluorescent agent has been added, and to image a surface of the body part. The device including a light source, two or more image sensors configured to capture fluorescent images and visible light images of the body part. The two or more image sensors are configured in that a viewing direction and/or a perspective of the fluorescence images and the visible light images are linked via a known relationship. A processor applies a stitching algorithm on the visible light images and similarly on the fluorescence images to generate a large visible light image and a large fluorescence image.

Abstract: An image capturing and processing device configured to measure a fluorescence signal in a tissue of a limb, to which a fluorescent agent has been added, and of determining a 3D representation of at least a section of the limb. The device including a light source, a fluorescence imaging sensor and processing configured to receive data on a topology of the surface of at least the section of the limb and to determine a 3D representation of at least the section of the limb from the data. The processor is further configured to output the fluorescence image and a visualization of the 3D representation.

Abstract: An endoscope includes a dichroic prism assembly configured to receive light from an object image through an entrance face. The assembly includes a first prism and a further dichroic prism assembly for splitting light in three light components, the first prism having a cross section with corners designed so that an incoming beam is partially reflected twice inside and exits the first prism through an exit face towards a first sensor. The dichroic prism assembly includes a compensator prism between the first prism and the further dichroic prism assembly. A first path length travelled by the part of the incoming beam reflected twice inside the first prism towards the first sensor is the same as path lengths travelled by a part of the incoming beam entering the further dichroic prism assembly towards each of three sensors, accounting for adjustment for focal plane focus position difference in wavelengths at the sensors.

Abstract: The invention relates to a method for detecting visible and infrared light using a medical imaging system, said medical imaging system comprising a camera module configured to receive a visible light signal and at least one infrared light signal from an object image. The medical imaging system for detecting visible and comprises an input for visible light for illuminating a tissue; an input for excitation light for exciting a fluorescence agent in the tissue; a camera module configured to receive a visible light signal and at least one infrared light signal from an object image in the tissue. The camera module comprises at least a first, second, and third optical path for directing light from the object image to a first, second, and third filter and sensor combination respectively. In any order, the first, second, and third filters are a green filter, an infrared filter, and a red/blue patterned filter comprising red and blue filters in alternating pattern.

Abstract: The invention relates to a method for detecting visible and infrared light using a medical imaging system, said medical imaging system comprising a camera module configured to receive a visible light signal and at least one infrared light signal from an object image. The medical imaging system for detecting visible and comprises an input for visible light for illuminating a tissue; an input for excitation light for exciting a fluorescence agent in the tissue; a camera module configured to receive a visible light signal and at least one infrared light signal from an object image in the tissue. The camera module comprises at least a first, second, and third optical path for directing light from the object image to a first, second, and third filter and sensor combination respectively. In any order, the first, second, and third filters are a green filter, an infrared filter, and a red/blue patterned filter comprising red and blue filters in alternating pattern.

Abstract: The invention relates to a method for detecting visible and infrared light using a medical imaging system, said medical imaging system comprising a camera module configured to receive a visible light signal and at least one infrared light signal from an object image. The medical imaging system for detecting visible and comprises an input for visible light for illuminating a tissue; an input for excitation light for exciting a fluorescence agent in the tissue; a camera module configured to receive a visible light signal and at least one infrared light signal from an object image in the tissue. The camera module comprises at least a first, second, and third optical path for directing light from the object image to a first, second, and third filter and sensor combination respectively. In any order, the first, second, and third filters are a green filter, an infrared filter, and a red/blue patterned filter comprising red and blue filters in alternating pattern.

Abstract: An endoscope includes a dichroic prism assembly configured to receive light from an object image through an entrance face. The assembly includes a first prism and a further dichroic prism assembly for splitting light in three light components, the first prism having a cross section with corners designed so that an incoming beam is partially reflected twice inside and exits the first prism through an exit face towards a first sensor. The dichroic prism assembly includes a compensator prism between the first prism and the further dichroic prism assembly. A first path length travelled by the part of the incoming beam reflected twice inside the first prism towards the first sensor is the same as path lengths travelled by a part of the incoming beam entering the further dichroic prism assembly towards each of three sensors, accounting for adjustment for focal plane focus position difference in wavelengths at the sensors.

Abstract: A dichroic prism assembly (P1-P7) configured to receive light from an object image through an entrance face of the dichroic prism assembly, includes a first prism (P3) and a further dichroic prism assembly (P5, P6, P7) for splitting light in three light components. The first prism has a cross section with at least five corners, and each corner has an inside angle of at least 90 degrees. The corners of the first prism are designed so that an incoming beam which enters the entrance face in a direction parallel to a normal of the entrance face is reflected twice inside the prism and exits the prism through an exit face parallel to a normal of the exit face.

Abstract: The invention relates to a method for detecting visible and infrared light using a medical imaging system, said medical imaging system comprising a camera module configured to receive a visible light signal and at least one infrared light signal from an object image. The medical imaging system for detecting visible and comprises an input for visible light for illuminating a tissue; an input for excitation light for exciting a fluorescence agent in the tissue; a camera module configured to receive a visible light signal and at least one infrared light signal from an object image in the tissue. The camera module comprises at least a first, second, and third optical path for directing light from the object image to a first, second, and third filter and sensor combination respectively. In any order, the first, second, and third filters are a green filter, an infrared filter, and a red/blue patterned filter comprising red and blue filters in alternating pattern.

Abstract: The invention relates to a dichroic prism assembly (P1-P7) configured to receive light from an object image through an entrance face of the dichroic prism assembly, comprising a first prism (P3) and a further dichroic prism assembly (P5, P6, P7) for splitting light in three light components, the first prism having a cross section with at least five corners, each corner having an inside angle of at least 90 degrees. The corners of the first prism are designed so that an incoming beam which enters the entrance face in a direction parallel to a normal of said entrance face is reflected twice inside the prism and exits the prism through an exit face parallel to a normal of said exit face, wherein the normal of the entrance face and the normal of the exit face are perpendicular to each other, and wherein the dichroic prism assembly comprises a compensator prism (P4) between the first prism and the further dichroic prism assembly.

Abstract: A method for detecting fluorescence radiation from a fluorescence agent, includes: emitting light at an excitation wavelength range (72) to cause fluorescence radiation emission in the fluorescence agent, the fluorescence radiation having a fluorescence wavelength profile (73); detecting light at a first fluorescence wavelength range (74) as a first detection signal (S1); detecting light at a second fluorescence wavelength range (81, 91) as a second detection signal (S2); and numerically determining a third detection signal with an improved fluorescence-to-background radiation ratio based on the first detection signal (S1), the second detection signal (S2), and the fluorescence wavelength profile (73).