Patents Assigned to Quiatech AB
  • Process for separating and deprotecting oligonucleotides
    Patent number: 7345163
    Abstract: Methods for deprotecting and derivatizing oligonucleotides that are non-covalently bound to a solid support are described. The methods include providing a plurality of oligonucleotides linked to one or more hydrophobic separation functions, wherein the plurality includes protected oligonucleotides, precipitating the plurality of oligonucleotides on a hydrophobic solid support using an organic solvent to produce non-covalently immobilized oligonucleotides, and deprotecting the immobilized oligonucleotides.
    Type: Grant
    Filed: August 28, 2002
    Date of Patent: March 18, 2008
    Assignee: Quiatech AB
    Inventor: Marek Kwiatkowski
  • Amplifiable probe
    Patent number: 7118864
    Abstract: Synthetic probes and methods for detecting analytes using such probes are described. The probes contain an analyte reactive moiety linked to a nucleic acid molecule that can be extended by DNA polymerase.
    Type: Grant
    Filed: May 9, 2002
    Date of Patent: October 10, 2006
    Assignee: Quiatech AB
    Inventor: Marek Kwiatkowski
  • Synthesis of oligonucleotides
    Patent number: 6790946
    Abstract: A method of preparing an immobilized oligonucleotide having a free 3′-end comprises the steps of: i) preparing an oligonucleotide attached in a first position to a solid support via its 3′-end and having a free 5′-end; ii) binding said oligonucleotide in a second position remote from the 3′-end to the solid support; and iii) selectively releasing the 3′-end of the oligonucleotide from the solid support to obta the oligonucleotide attached to the support in said second position in a reversed orientation with a free 3′-end.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: September 14, 2004
    Assignee: Quiatech AB
    Inventors: Marek Kwiatkowski, Ulf Landegren, Mats Nilsson
  • Compounds for protecting hydroxyls and methods for their use
    Publication number: 20040175726
    Abstract: A hydrocarbyldithiomethyl-modified compound of the Formula:
    Type: Application
    Filed: October 27, 2003
    Publication date: September 9, 2004
    Applicant: Quiatech AB, a Swedish corporation
    Inventor: Marek Kwiatkowski
  • Solid phase synthesis
    Patent number: 6646118
    Abstract: The present invention relates to a support system for solid phase synthesis of oligomers, such as oligonucleotides, wherein the starting compound is bound to the support via a disiloxyl linkage. Furthermore, the invention relates to a method for synthesis of oligonucleotides on a solid support. The support system comprises a stable disiloxyl linkage providing high nucleoside loadings to the support and the method allows convenient non-laborious oligomer synthesis.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: November 11, 2003
    Assignee: Quiatech AB
    Inventors: Marek Kwiatkowski, Mats Nilsson, Ulf Landegren
  • Compounds for protecting hydroxyls and methods for their use
    Patent number: 6639088
    Abstract: A hydrocarbyldithiomethyl-modified compound of the Formula: R1—O—CH2—S—S—R2 or a salt thereof wherein R1 is an organic molecule and R2 is a hydrocarbyl is useful for protecting and/or blocking hydroxyl groups in organic molecules such as nucleotides. The hydrocarbyldithiomethyl-modified compounds can also be used for chemically synthesizing oligonucleotides and for sequencing nucleic acid compounds.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: October 28, 2003
    Assignee: Quiatech AB
    Inventor: Marek Kwiatkowski
  • Solid phase synthesis
    Publication number: 20020177698
    Abstract: The present invention relates to a support system for solid phase synthesis of oligomers, such as oligonucleotides, wherein the starting compound is bound to the support via a disiloxyl linkage. Furthermore, the invention relates to a method for synthesis of oligonucleotides on a solid support. The support system comprises a stable disiloxyl linkage providing high nucleoside loadings to the support and the method allows convenient non-laborious oligomer synthesis.
    Type: Application
    Filed: March 25, 2002
    Publication date: November 28, 2002
    Applicant: Quiatech AB
    Inventors: Marek Kwiatkowski, Mats Nilsson, Ulf Landegren
  • Solid phase synthesis
    Patent number: 6429309
    Abstract: The present invention relates to a support system for the solid phase synthesis of oligomers, such as oligonucleotide, wherein the starting compound is bound to the support via a disiloxyl linkage. Furthermore, the invention relates to a method for synthesis of oligonucleotides on a solid support. The support system comprises a stable disiloxyl linkage providing high nucleoside loadings to the support and the method allows convenient non-laborious oligomer synthesis.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: August 6, 2002
    Assignee: Quiatech AB
    Inventors: Marek Kwiatkowski, Mats Nilsson, Ulf Landegren