Patents Assigned to Quorex Pharmaceuticals, Inc.
  • Compounds and methods for regulating bacterial growth and pathogenesis
    Patent number: 7666619
    Abstract: The invention provides autoinducer-2 analogs that regulate the activity of autoinducer-2 and methods of using such analogs for regulating bacterial growth and pathogenesis.
    Type: Grant
    Filed: March 17, 2004
    Date of Patent: February 23, 2010
    Assignees: Princeton University, Quorex Pharmaceuticals, Inc., University Technologies International, Inc.
    Inventors: Bonnie L. Bassler, Stephan Schauder, Kevan Shokat, Michael G. Surette
  • Anti-bacterial agents based upon oxoanion binding
    Patent number: 7074776
    Abstract: Compounds of the structure I: are useful for treating bacterial growth, wherein E is selected from the group consisting of B, P, and S, T1 and T2 are each independently selected from the group consisting of O, NR, and CH2, where R?H or C1–C8 alkyl, or C1–C8 oxoalkyl, and L is selected from the group consisting of ethylene, propylene, and four to six-membered alicyclic and aromatic rings, provided that structure I does not include AI-2-borate. The compounds may be used to treat bacterial infections in human beings and to regulate biofilm formation. Pharmaceutical compositions comprising one or more such compounds are useful for treating bacterial infections in human beings.
    Type: Grant
    Filed: October 1, 2003
    Date of Patent: July 11, 2006
    Assignee: Quorex Pharmaceuticals, Inc.
    Inventors: Stephen R. Cooper, Kraig M. Yager
  • Compounds and methods for regulating bacterial growth and pathogenesis
    Patent number: 6780890
    Abstract: The invention provides autoinducer-2 analogs that regulate the activity of autoinducer-2 and methods of using such analogs for regulating bacterial growth and pathogenesis.
    Type: Grant
    Filed: November 19, 2002
    Date of Patent: August 24, 2004
    Assignees: University Technologies International, Inc., Quorex Pharmaceuticals, Inc., Princeton University
    Inventors: Bonnie L. Bassler, Carol Dammel, Stephan Schauder, Kevan Shokat, Jeffrey Stein, Michael G. Surette
  • Anti-bacterial agents based upon oxoanion binding
    Patent number: 6737415
    Abstract: Compounds of the structure I: are useful for treating bacterial growth, wherein E is selected from the group consisting of B, P, and S, T1, and T2 are each independently selected from the group consisting of O, NR, and CH2, where R=H or C1-C8 alkyl, or C1-C8 oxoalkyl, and L is selected from the group consisting of ethylene, propylene, and four to six-membered alicyclic and aromatic rings, provided that structure I does not include AI-2-borate. The compounds may be used to treat bacterial infections in human beings and to regulate biofilm formation. Pharmaceutical compositions comprising one or more such compounds are useful for treating bacterial infections in human beings.
    Type: Grant
    Filed: August 22, 2002
    Date of Patent: May 18, 2004
    Assignee: Quorex Pharmaceuticals, Inc.
    Inventors: Stephen R. Cooper, Kraig M. Yager
  • Compounds and methods for regulating bacterial growth and pathogenesis
    Patent number: 6559176
    Abstract: The invention provides autoinducer-2 analogs that regulate the activity of autoinducer-2 and methods of using such analogs for regulating bacterial growth and pathogenesis.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: May 6, 2003
    Assignees: Princeton University, Quorex Pharmaceuticals, Inc., University Technologies International, Inc.
    Inventors: Bonnie L. Bassler, Carol Dammel, Stephan Schauder, Kevan Shokat, Jeffrey Stein, Michael G. Surette