Abstract: Described is a composition that includes: (i) a drug against tuberculosis inhibiting the cytochrome b subunit of the bc1 complex, said cytochrome b subunit being encoded by the gene qcrB, in Mycobacterium tuberculosis, or a pharmaceutically acceptable salt thereof, and (ii) a compound of Formula II, or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
October 5, 2018
Date of Patent:
September 28, 2021
Assignees:
Quretech Bio AB, Washington University in St. Louis
Inventors:
Christina Leigh Stallings, Gregory Alexander Harrison, Fredrik Almqvist, Souvik Sarkar
Abstract: The present disclosure provides a combination comprising: (i) a drug against tuberculosis, or a pharmaceutically acceptable salt thereof, and (ii) a compound of Formula II, or a pharmaceutically acceptable combination thereof. The combination may be used in the treatment and/or prevention of tuberculosis.
Type:
Grant
Filed:
April 7, 2017
Date of Patent:
March 16, 2021
Assignees:
QURETECH BIO AB, WASHINGTON UNIVERSITY IN SAINT LOUIS
Inventors:
Christina L. Stallings, Fredrik Almqvist, Kelly Flentie, James Arthur Dudley Good, Fritiof Ponten
Abstract: The disclosure relates to certain novel substituted ring-fused thiazolino 2-pyridines of Formula I, to processes for preparing such compounds, to their use in treating a bacterial infection such as Chlamydia infection, to methods for their therapeutic use and to pharmaceutical compositions containing them.
Type:
Grant
Filed:
November 13, 2015
Date of Patent:
May 21, 2019
Assignee:
QURETECH BIO AB
Inventors:
James Arthur Dudley Good, Anna Martina Kulén, Klas Fredrik Almqvist, Andrew Gerard Cairns, John Fritiof Pontén