Abstract: A process of preparation of O-Desmethyl tramadol through potassium hydroxide mediated demethylation of Tramadol under phase transfer conditions.
Abstract: A process of preparation of O-Desmethyl tramadol through potassium hydroxide mediated demethylation of Tramadol under phase transfer conditions.
Abstract: A high yield process of preparation of [1-[2-(Dimethylamino)-1-(4-hydroxyphenyl)ethy]-cyclohexanol] through potassium salt mediated demethylation of [1-[2-(Dimethyl amino-1-(4-methoxyphenyl) ethyl cyclohexanol] in monoethylene glycol under phase transfer conditions, as well as the preparation of salt of [1-[2-(Dimethylamino)-1-(4-hydroxyphenyl)ethyl]-cyclohexanol].
Type:
Grant
Filed:
March 31, 2017
Date of Patent:
November 5, 2019
Assignee:
R L FINECHEM PRIVATE LIMITED
Inventors:
Ramesha A. Ramakrishna, Siddegowda S. Maravanahalli
Abstract: A high yield process of preparation of, [1-[2-(Dimethylamino)-1-(4-hydroxyphenyl)ethy]-cyclohexanol] through potassium hydroxide mediated demethylation of [1-[2-(Dimethyl amino-1-(4-methoxyphenyl) ethyl cyclohexanol] in monoethylene glycol under phase transfer conditions, as well as the preparation of salt of [1-[2-(Dimethylamino)-1-(4-hydroxyphenyl)ethyl]-cyclohexanol].
Type:
Application
Filed:
March 31, 2017
Publication date:
September 6, 2018
Applicant:
R L FINECHEM PRIVATE LIMITED
Inventors:
Ramesha A. RAMAKRISHNA, Siddegowda S. MARAVANAHALLI