Abstract: This invention relates to a solvent system for enhancing the solubility of an acidic, basic, or amphoteric pharmaceutical agent to produce a highly concentrated solution suitable for softgel filling or two piece encapsulation. The solvent system comprises polyethylene glycol containing 0.2-1.0 mole equivalents of an ionizing agent per mole equivalent pharmaceutical agent and 1-20% water. Glycerin or polyvinylpyrrolidone may be added to further enhance the solubility of certain drugs. The disclosed solvent system is capable of enhancing solubilities of pharmaceutical agents 40-400%.The ionizing agent functions by causing partial ionization (neutralization) of the free pharmaceutical agent. When the pharmaceutical agent is acidic, the ionizing agent is preferably a hydroxide ion species, whereas when the pharmaceutical agent is basic, the ionizing agent is preferably a hydrogen ion species.
Type:
Grant
Filed:
May 26, 1992
Date of Patent:
November 1, 1994
Assignee:
R. P. Scherer Corp.
Inventors:
Man S. Yu, Foo S. Hom, Sibaprasanna Chakrabarti, Chong-Heng Huang, Mahendra Patel
Abstract: A preparation for pharmaceutical use, especially in the treatment of migraine, arthritis and bronchial complaints contains a sesquiterpene lactone and is recovered from the plant Tanacetum parthenium by extraction using a pharmaceutically acceptable oil.
Type:
Grant
Filed:
June 26, 1985
Date of Patent:
July 19, 1988
Assignee:
R. P. Scherer Corp.
Inventors:
Edward S. Johnson, Peter J. Hylands, Deborah M. Hylands nee Jessup