Abstract: The invention described herein relates to a pharmaceutical composition containing vinorelbine as an active ingredient which is suitable for encapsulation in soft capsules. The liquid oral pharmaceutical composition suitable for a liquid fill composition for a soft capsule dosage form comprises: vinorelbine or a pharmaceutically acceptable salt thereof; ethanol; water; glycerol; and polyethylene glycol. In a preferred embodiment, the tartrate salt form of vinorelbine is used in the composition. The invention also provides for a method of treating cancer comprising orally administering, to a patient in need of treatment thereof, a soft capsule comprising the pharmaceutical composition of the invention.

Abstract: A peelable pouch 50 for containing a single dosage product P having a top layer 100 joined to a bottom layer 200 by at least one seal 500 thereby creating a primary compartment 300. The primary compartment 300 houses the product P, sealed from the exterior environment. The peelable pouch 50 includes a tear promoting surface condition 600 on the top layer 100 and the bottom layer 200 intersected by a fold-over line 700. When the pouch 50 is folded about the fold-over line 700 the tear promoting surface condition 600 permits a user to easily tear off a portion of the pouch 50 and expose a portion of the primary compartment 300 allowing the product P to be removed from the pouch 50. Alternative embodiments incorporate a product retention edge 350 that requires supplemental separation of the top 100 and bottom 200 layers to gain access to the product P, as well as a secondary compartment 400 formed between the top 100 and bottom 200 layers.

Abstract: A nozzle device is disclosed that may be used with a fluid-bed dryer apparatus or system. Such a nozzle device includes, in one embodiment, an intake block, an inner tube, an outer tube, a tip and an air cap. The tubes are connected to the intake block to form a passage for liquid and a passage for gas. The tip connects to the inner tube, and the air cap connects to the outer tube, so that at the output the fluid is atomized by the gas. Flow of the liquid and gas through the nozzle is unimpeded, and the nozzle provides substantially constant atomization characteristics.

Abstract: A child resistant senior friendly medication storage and distribution package including a blister portion and a blocking substrate sandwiched between a dispensing substrate and a backing substrate. The procedure to access the medicament is easy for an adult to understand and accomplish, yet difficult for most children. The blister portion contains a base layer and a blister layer. The blister layer includes an article receiving blister designed for holding the medicament. The dispensing substrate has a dispensing substrate blister receiver. The blister receiver is configured to cooperate with the blister so it extends through the dispensing substrate. The blocking substrate includes a gate that initially covers a portion of the blister. The gate must be moved, or slid, out of the way in order to eject the medicament. The user applies a force to the gate causing it to translate between the backing substrate and the dispensing substrate.

Abstract: A storage and dispensing apparatus designed to contain pre-measured amounts of a substance(s). The apparatus comprises at least one compartment, preferably at least two compartments, for storing the substance(s) that is partially enclosed by a frangible seal, an applicator or dispensing conduit, and an expandable chamber designed to accept and dissipate the hydraulic force created when pressure is applied to the at least one compartment rupturing the frangible seal, and expelling the substance(s) into the chamber. The applicator is attached to the chamber with an applicator bond area. The expandability of the chamber is conferred by expandability of the chamber walls and of the applicator, when present, and is varied in different embodiments by altering the ratio between the area of the applicator bond area and the area of the applicator. The frangible seal, in one of many embodiments, may be a chevron shape stress riser with a point of inflection oriented towards the compartment.

Abstract: A container for housing blister packs. The container includes first and second portions attached to one another in a manner whereby said first and second portions are movable from an open condition in which products may be dispensed from the container to a closed condition in which products cannot be dispensed from the container. At least the first portion of the container defines an internal space in said container of sufficient size to receive product in said internal space. The container also includes structure for supporting the blister pack in a position whereby product dispensed from said blister pack is dispensed into the internal space in said container and a closure which retains said first and second portions in the closed position.

Abstract: A child resistant product dispenser includes a blister card having compartments for holding a product a housing, and a blister cover for use in covering the blister card compartments. The blister cover may include a dispensing area for each compartment of the blister card. To remove a product from the product dispenser the user presses a dispensing area against either a compartment thereby forcing the product through a frangible area on the blister card and through a frangible area in the housing or against a peelable area on the blister card and a frangible area in the housing. This creates an opening through which the product is removed.

Abstract: A child resistant product dispenser includes a blister card having compartments for holding a product, a housing, and a blister cover for use in covering the blister card compartments. The blister cover may include a dispensing area for each compartment of the blister card. To remove a product from the product dispenser the user presses a dispensing area against either a compartment thereby forcing the product through a frangible area on the blister card and through a frangible area in the housing or against a peelable area on the blister card and a frangible area in the housing. This creates an opening through which the product is removed.

Abstract: A shielded medication package including a blister portion and a blister shield attached to a backing substrate. Accessing a medicament is easy for an adult to accomplish, yet the package resists children biting and picking at the blister portion. The blister portion contains a base layer and a blister layer. The blister layer includes an article receiving blister designed for holding the medicament. A blister shield overlays the blister portion. The blister shield includes a blister well that cooperates with the article receiving blister. The blister shield protects the article receiving blister from substantially lateral forces. To eject the medicament, application of a substantially orthogonal force to the article receiving blister is required.

Abstract: A single-use, multi-chamber package for housing and common administration of at least two flowable substances. The package includes at least first and second product storage cavities; and at least first and second product application channels. At least one separation line selectively reduces the strength of a predetermined area of the package and generally defines a tab. Steps of use include: 1) applying a force to tab creation areas to separate a portion of a tab; 2) removing the tab from the blister package by tearing across the product application channels to form wings, exposing the interior of the product application channels; 3) rotating the wings to pivot the channel openings toward one another, and 4) applying a force to the storage cavities to dispense the products. The package may contain more than two substances by employing multiple storage cavities and application channels.

Abstract: Apparatus for producing image bearing filled gelatin capsules (12 and 16) for directing gelatin ribbon (2,4) from respective casting drums to an encapsulation station (6). Along the path of at least one ribbon (4) is a transfer station (18) at which images are applied to the ribbon. The images are applied in a pattern which corresponds to the pattern of capsules formed from the ribbon at the encapsulation station (6). Both the rollers (8) at the encapsulation station, and a support roller at or adjacent the transfer station are positively drive, and a control system ensures that the peripheral speed of a support roller (16) in the transfer station (18) is the same as the speed of the ribbon into and through the encapsulation station. The drive motor for the respective support roller in the transfer station is preferably a stepping motor, adjustable to advace or retard relative to the ribbon spped in the encapsulation station (6).

Abstract: The invention herein relates to a pharmaceutical composition containing loratadine and derivatives thereof which is suitable for use in soft capsule dosage forms. A pharmaceutical composition according to the invention comprises loratadine and derivatives thereof in a pharmaceutically effective amount; and a solvent system comprising a mixture of medium chain fatty acids. The loratadine compositions exhibit good solubility and storage stability while maintaining bioavailability of the drug. The compositions also permit high concentrations of solubilized loratadine per total fill volume and thereby permit the use of smaller capsules to deliver the same dosage of drug.

Abstract: The invention herein relates to a method and apparatus for forming (or cold-forming) an embossed blister from a laminated film wherein an indicia is formed on the base of the blister. In particular, the invention involves a single pass process of combining the formation of a blister and the formation of an indicia (embossing) on the blister, wherein the blister-forming pin contains a face with an indicia and is adapted to controllably stretch the laminated film during blister formation to minimize stretching of the film at the base of the blister. The invention is particularly useful in manufacturing processes which involve the formation of blisters having laminated films which contain a metal foil and polymer layer, wherein improved control in the stretching of the laminate during blister formation is desirable.

Abstract: This invention relates to a pharmaceutical composition for oral administration comprising a carrier and, as active ingredient, an opioid (? receptor) agonist, such as fentanyl, or a salt thereof, characterized in that the composition is in the form of a fast-dispersing dosage form designed to release the active ingredient rapidly in the oral cavity. A process for preparing such a composition and the use of such a composition as an analgesic, for the treatment of chronic pain and/or breakthrough pain, as an anesthetic premedication, for the induction of anesthesia, as a sedative and/or for the treatment of anxiety are also provided.

Abstract: A container and storage apparatus with an attached, but functionally separate, labeling portion is provided. The apparatus has a primary chamber containing a predetermined agent separated from the labeling portion. An optional contamination barrier region may increase the separation. A preferred embodiment may be formed by a blow-fill-seal method from thermoplastic, allowing one piece molding of the apparatus. A removable cap allows a dispensing point to be opened into the primary chamber for removal of the agent. Indicia may be formed in or on the labeling portion, which may be smaller, larger, or the same in size and shape as the primary chamber. Inks, adhesives or other substances incidental to the indicia will be less likely to migrate across the apparatus wall and into the primary chamber due to the functional separation provided between the primary chamber and labeling portion.

Abstract: The invention herein provides for an oral pharmaceutical composition adapted for use in capsular dosage forms comprising acetaminophen and a lactate salt alone or in combination with an acetate salt. Compositions of the invention exhibit improved solubility characteristics of the active ingredient per given fill volume, thereby permitting the use of smaller capsule sizes to deliver a given effective dose of the active ingredient. Compositions of the invention also exhibit improved clarity per concentration of active ingredient. The invention also provides for a capsular dosage form containing the composition.

Abstract: Disclosed herein are compositions comprising a modified starch and a carrageenan, especially iota-carrageenan, where the compositions are suitable for use in manufacturing soft capsules.