Patents Assigned to R2 Diagnostics, Inc.
  • Method for measuring antithrombin activity
    Patent number: 6432658
    Abstract: The invention provides a one-stage method of measuring antithrombin (AT) activity in a sample. In the method, a diluted sample is mixed with AT-deficient plasma containing intrinsic coagulation enzymes, an AT augmenting compound such as heparin, a phospholipid and an activator of the contact phase of the intrinsic coagulation pathway. Following addition of calcium ions, coagulation time is measured and compared to a reference standard to determine the level of AT activity in the sample.
    Type: Grant
    Filed: September 13, 2000
    Date of Patent: August 13, 2002
    Assignees: Affinity Biologicals, Inc., R2 Diagnostics, Inc.
    Inventors: Hugh W. Hoogendoorn, Alexander Duncan, Michael J. Morris