Abstract: The present is directed to improved systems, methods, and devices for providing skin cooling treatment. The skin cooling treatment system can include a mechanical arm and a cryospray applicator coupled to a distal end of the mechanical arm. The skin cooling treatment system can include a processor that can receive imagery of a portion of skin of a patient for receiving a skin cooling treatment and automatically identify boundaries from the received imagery to designate portions of the skin of the patient for receiving the skin cooling treatment. The processor can determine an instantaneous treatment footprint and can generate a treatment path based on the treatment footprint. The processor can control the cryospray applicator to deliver the skin cooling treatment to the skin according to the treatment path.

Abstract: Embodiments of the present invention generally relate to methods, devices, and systems for reducing a pigmentation of a skin of a patient. In some embodiments, freezing of the skin may be desirable to effect the hypopigmentation of the skin of the patient. Generally, embodiments may limit supercooling (or promote freezing) of the skin of the patient during a cooling treatment. In some embodiments, coupling fluids are provided to reduce a thermal contact resistance between a cooling treatment probe and the skin of the patient to improve cooling treatment. Optionally, a fluid carrier may be provided to help retain the coupling fluid at the treatment site. In some embodiments, the coupling fluid may include ice nucleating agents to promote ice crystal formation in the coupling fluid during cooling treatment. The ice crystal formation in the coupling fluid may progress into the skin to limit supercooling of the skin during treatment.

Abstract: The present is directed to improved systems and methods for skin cooling treatments. A skin cooling treatment system can include a mechanical arm that can have a proximal end and an distal end. The system can include a processor that can control the mechanical arm, and a cryospray applicator. The cryospray applicator can be coupled to the distal end of the mechanical arm and can be moveable by the mechanical arm to deliver a spray of cryogen to a portion of an area of skin tissue for treatment. The cryospray applicator can include an array of orifices through which the cryogen can be sprayed.

Abstract: The present invention is directed to improved systems, devices, and methods for delivery of a cryogen to the skin of a patient for skin treatment. A cryospray device configured to deliver a cryogen to a patient's skin can include an applicator, a supply channel, and a nozzle assembly. The applicator can include a head portion, and the supply channel can extend through at least a portion of the head portion. The nozzle assembly can be coupled to the head portion and can be fluidly coupled to the supply channel. The nozzle assembly can include a linear array of orifices that are configured to direct a planar spray of the cryogen to cool an area of a skin tissue of the patient in a linear cooling treatment.

Abstract: The present invention generally relates to improved medical devices, systems, and methods, with exemplary embodiments providing improved cooling treatment probes and cooling treatment methods and systems. In some embodiments, freezing of the skin may be desirable to effect the hypopigmentation of the skin of the patient. Generally, embodiments may limit supercooling of the skin of the patient during a cooling treatment. Additionally, embodiments may limit adverse side effects such as hyperpigmentation. It has been found that the freezing behavior (frequency and time to freeze) can be modified by adjusting the thermal parameters of the cooling applicator. Accordingly, in some aspects of the invention, a method of treating the skin may be provided where the thermal parameters of the cooling applicator are adjusted during treatment.

Abstract: The present invention is directed to improved systems, devices, and methods for delivery of a cryogen to the skin of a patient for skin treatment. A cryospray device configured to deliver a cryogen to a patient's skin can include an applicator, a supply channel, and a nozzle assembly. The applicator can include a head portion, and the supply channel can extend through at least a portion of the head portion. The nozzle assembly can be coupled to the head portion and can be fluidly coupled to the supply channel. The nozzle assembly can include a linear array of orifices that are configured to direct a planar spray of the cryogen to cool an area of a skin tissue of the patient in a linear cooling treatment.

Abstract: Embodiments of the present invention generally relate to methods, devices, and systems for reducing a pigmentation of a skin of a patient. In some embodiments, freezing of the skin may be desirable to effect the hypopigmentation of the skin of the patient. Generally, embodiments may limit supercooling (or promote freezing) of the skin of the patient during a cooling treatment. In some embodiments, coupling fluids are provided to reduce a thermal contact resistance between a cooling treatment probe and the skin of the patient to improve cooling treatment. Optionally, a fluid carrier may be provided to help retain the coupling fluid at the treatment site. In some embodiments, the coupling fluid may include ice nucleating agents to promote ice crystal formation in the coupling fluid during cooling treatment. The ice crystal formation in the coupling fluid may progress into the skin to limit supercooling of the skin during treatment.

Abstract: A region-growing method for identifying nodules in an anatomical volume segments a 3-D image volume by controlled voxel growth from seed points. The process is based on creation and use of a distance map for tracking the distance of vessel voxels from a predetermined location. A volume map is created that identifies the largest sphere that can pass between a voxel and a predetermined location without touching a non-vessel voxel. The ratio between the distance map and the volume map is analyzed to find regions more likely to contain nodules, the features of which can be extracted or otherwise highlighted.

Abstract: A CAD system pre-analyzes a medical image to automatically determine whether contrast agent was introduced into the patient before forming that image. In one embodiment, contrast agent detection is performed by comparing the voxel values in known blood-containing areas to voxel values of known water-containing areas, and if there is a substantial difference above a preferred threshold, then it is determined that this patient was indeed injected with the contrast agent. Upon finding that the patient was indeed injected with contrast agent, the CAD algorithm then automatically performs both a detection algorithm that uses the contrast agent and one that does not and notifies the clinician that both sets of results are available to look at. However, if it is determined that the patient was not injected with contrast agent, the CAD algorithm does not perform the algorithm that uses the contrast agent does not give the user the option to view any results from such algorithm.

Abstract: A method and system of volume segmentation is disclosed. To address throughput speed and accuracy requirements, the segmentation is divided into two stages: presegmentation and detailed segmentation. In presegmentation, a digital image volume is processed to identify anatomical structures from image backgrounds in a gross manner possibly at reduced image resolution. Detailed segmentation then involves refining and segmenting further the fine details within the anatomical structures identified by presegmentation. One result of the overall volume segmentation algorithm is a volume in which segmented regions of interest, such as nodules, are identified.

Abstract: A method, system, and related computer program products are provided for processing a medical image of a body part according to a computer-aided detection (CAD) algorithm, the medical image having an image border, the body part comprising imaged tissue appearing inside the image border and outlying tissue not appearing in the medical image, wherein likely anatomical abnormalities in the outlying tissue near the imaged tissue border are detected by the CAD algorithm. In one example, the detected likely abnormalities in the outlying tissue are located within a first distance from the imaged tissue border, wherein the first distance corresponds to a spatial ambit of a neighborhood-based feature computed by the CAD algorithm.

Abstract: A method and apparatus for providing testing a computer aided diagnosis (CAD)-based system comprising receiving radiological image of a patient acquired using at least one piece of radiological equipment at least partially controlled by a technologist, the patient being controlled by the technologies relative to the radiological equipment in acquiring said radiological image.

Abstract: An algorithm is quickly scans a digital image volume to detect density nodules. A first stage is based on a transform to quickly highlight regions requiring further processing. The first stage operates with somewhat lower sensitivity than is possible with more detailed analyses, but operates to highlight regions for further analysis and processing. The transform dynamically adapts to various nodule sizes through the use of radial zones. A second stage uses a detailed gradient distribution analysis that only operates on voxels that pass a threshold of the first stage.

Abstract: A region-growing method for identifying nodules in an anatomical volume segments a 3-D image volume by controlled voxel growth from seed points. The process is based on creation and use of a distance map for tracking the distance of vessel voxels from a predetermined location. A volume map is created that identifies the largest sphere that can pass between a voxel and a predetermined location without touching a non-vessel voxel. The ratio between the distance map and the volume map is analyzed to find regions more likely to contain nodules, the features of which can be extracted or otherwise highlighted.

Abstract: Facilitating viewer comparison of a plurality of medical images of at least one body part on a softcopy review workstation is described. First and second medical images are displayed such that the second medical image appears as a spatially registered underlay to the first medical image exposed through an aperture therein. The aperture comprises at least one edge that is viewer-manipulable in a back-and-forth manner so that the first and second medical images can be visually compared with minimal eye movement. For a temporal comparison embodiment, the first and second medical images comprise identical views of the same body part acquired at different times. For a cross-modality comparison embodiment, the first and second medical images are acquired substantially concurrently, or at different times, using different medical imaging modalities. For a bilateral comparison embodiment, the first and second images are corresponding views of two laterally corresponding body parts.