Patents Assigned to RADBOUD UNIVERSITEIT NIJMEGEN
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Patent number: 10350298Abstract: The present invention relates to protein constructs that comprise one or more peptides, proteins, factors, compounds or other components as further described herein that are linked to and/or are linked to each other via a helical polymeric backbone. The constructs of the invention are suitable for administration to a human or animal body and can be used for pharmaceutical purposes, for example, for immunotherapy, such as for treating cancer and for other immunological applications, as well as for other therapeutic, prophylactic and/or diagnostic purposes.Type: GrantFiled: July 7, 2011Date of Patent: July 16, 2019Assignees: Stichting Katholieke Universiteit, Radboud University Nijmegen Medical Centre, Stichting Katholieke Universiteit, meer in het bijzonder Radboud Universiteit NijmegenInventors: Alan Edward Rowan, Carl Gustav Figdor
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Patent number: 10125222Abstract: The present invention relates to a process for the preparation of oligo(alkylene glycol)-functionalized polyisocyanopeptides comprising the steps of functionalizing an isocyanopeptide with oligo-(alkylene glycol) side chains and subsequently polymerizing the oligo-alkylene glycol-functionalized isocyanopeptides. Several isocyanopeptides may be functionalized with various linear or non-linear oligo-(alkylene glycol) side chains having variable chain length. The alkylene glycol may be selected from the group consisting of ethylene-, propylene-, butylene- or pentylene glycol. Preferably, the isocyanopeptides are functionalized with at least three ethylene glycol side chains. The peptides may comprise L-amino acids, D-amino acids or D, L-amino acids. The obtained oligoalkylene-functionalized polyisocyanopeptides are a new class of materials with unique thermo-responsive properties.Type: GrantFiled: December 8, 2016Date of Patent: November 13, 2018Assignee: STICHTING KATHOLIEKE UNIVERSITEIT MEER IN HET BIJZONDER RADBOUD UNIVERSITEIT NIJMEGENInventors: Alan Edward Rowan, Roeland Johannes Maria Nolte, Jeroen Johannes Lambertus Maria Cornelissen, Heather Joy Kitto, Erik Schwartz, Matthieu Koepf
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Patent number: 9773603Abstract: A method of magnetization reversal, time stable ferrimagnetic material, a product and a domain comprising said material, a system for magnetization reversal, and information storage. Therein, a ferrimagnetic material is one in which magnetic moments of the atoms on different sublattices are opposed, as in antiferromagnetism; however, in ferrimagnetic materials, the opposing moments are unequal and a spontaneous magnetization remains.Type: GrantFiled: June 23, 2014Date of Patent: September 26, 2017Assignee: RADBOUD UNIVERSITEIT NIJMEGENInventors: Theodorus Henricus Maria Rasing, Johan Mentink, Andrei Kirilyuk, Alexey Kimel, Richard Francis Llewelyn Evans, Roy William Chantrell, Thomas Andrew Ostler, Joseph Barker
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Patent number: 8981001Abstract: The present invention relates to a process for the preparation of oligo(alkylene glycol) functionalized polyisocyanopeptides comprising the steps of functionalizing an isocyanopeptide with oligo-(alkylene glycol) side chains and subsequently polymerizing the oligo-alkylene glycol functionalized isocyanopeptides. Several isocyanopeptide may be functionalized with various linear or non-linear oligo-(alkylene glycol) side chains having variable chain length. The alkylene glycol may be selected from the group consisting of ethylene-, propylene-, butylene- or pentylene glycol. Preferably the isocyanopeptides are functionalized with at least 3 ethylene glycol side chains. The peptides may comprise L aminoacids, D-aminoacids or D, L-aminoacids. The obtained oligoalkylene functionalized polyisocyanopeptides are a new class of materials with unique thermo-responsive properties.Type: GrantFiled: July 16, 2010Date of Patent: March 17, 2015Assignee: Stichting Katholieke Universiteit Meer in Het Bijzonder Radboud Universiteit NijmegenInventors: Alan Edward Rowan, Roeland Johannes Maria Nolte, Jeroen Johannes Lambertus Maria Cornelissen, Heather Joy Kitto, Erik Schwartz, Matthieu Koepf
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Publication number: 20120149836Abstract: The present invention relates to a process for the preparation of oligo(alkylene glycol) functionalized polyisocyanopeptides comprising the steps of functionalizing an isocyanopeptide with oligo-(alkylene glycol) side chains and subsequently polymerizing the oligo-alkylene glycol functionalized isocyanopeptides. Several isocyanopeptide may be functionalized with various linear or non-linear oligo-(alkylene glycol) side chains having variable chain length. The alkylene glycol may be selected from the group consisting of ethylene-, propylene-, butylene- or pentylene glycol. Preferably the isocyanopeptides are functionalized with at least 3 ethylene glycol side chains. The peptides may comprise L aminoacids, D-aminoacids or D, L-aminoacids. The obtained oligoalkylene functionalized polyisocyanopeptides are a new class of materials with unique thermo-responsive properties.Type: ApplicationFiled: July 16, 2010Publication date: June 14, 2012Applicant: Stichting Katholieke Universiteit Meer in Het Bijzonder Radboud Universiteit NijmegenInventors: Alan Edward Rowan, Roeland Johannes Maria Nolte, Jeroen Johannes Lambertus Maria Cornelissen, Heather Joy Kitto, Erik Schwartz, Matthieu Koepf
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Publication number: 20120100514Abstract: Method for training of a perceptual skill, e.g. using a brain computer interface, which method comprises measuring electrophysiological activity in reaction to a sequence of perceptual stimuli. Furthermore, matching the measured electrophysiological activity signal with a predefined electrophysiological signature signal is performed, in which the predefined electrophysiological signature signal corresponds to an early electrophysiological component. Feedback is provided when a match is detected.Type: ApplicationFiled: April 2, 2010Publication date: April 26, 2012Applicant: Stichting Katholieke Universiteit, Radboud Universiteit NijmegenInventors: Petrus Wilhelmus Maria Desain, James Maurice McQueen
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Publication number: 20080210628Abstract: The invention relates to a process for the biological treatment of ammonium-rich aqueous media in the presence of ammonia oxidizing bacteria, by supplying nitrogen dioxide (NO2) into said aqueous media, thus effecting a nitrification and a denitrification, wherein further nitrogen oxide (NO) is supplied into said media such that the ratio of NO:NO2 is in the range from 1:2 to 1:500 (v/v). Further the use of off-gases in this process is disclosed as well as microorganisms cultured in the presence of NO and NO2.Type: ApplicationFiled: May 16, 2003Publication date: September 4, 2008Applicants: Grontmij Advies & Techniek B.V., Stichting Voor DeTechnische Wetenschappen, Stichting Katholieke Universiteit Genoemd Radboud Universiteit NijmegenInventors: Ingo Schmidt, Michael Silvester Maria Jetten, Rogier Nicolaas Antonius Van Kempen