Patents Assigned to RADIKAL THERAPEUTICS INC.
  • Substituted 1-pyrrolidinyloxy, 1-piperidinyloxy and 1-azepanyloxy compounds for treating diseases associated with oxidative stress or endothelial dysfunction
    Patent number: 9604932
    Abstract: Compounds are of the class of 1-pyrrolidinyloxy,1-piperidinyloxy, and 1-azepanyloxy derivatives of formula (I): The compounds are useful in prevention, treatment or management of diseases, disorders or conditions associated with oxidative stress or endothelial dysfunction. The compounds include 2,2,5,5,-tetramethyl-3-(nitrooxymethyl)pyrrolidin-1-yl acetate.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: March 28, 2017
    Assignee: Radikal Therapeutics Inc.
    Inventors: Andrew Lurie Salzman, Prakash Jagtap, Garry John Southan
  • Multifunctional nitroxide derivatives and uses thereof
    Patent number: 9522903
    Abstract: Multifunctional nitroxide derivatives comprising a potassium channel opener and a reactive oxygen species (ROS) degradation catalyst that can act as an anti-oxidant, as well as pharmaceutical compositions comprising them are provided. The multifunctional compounds and pharmaceutical compositions are useful for treatment of diseases, disorders or conditions associated with oxidative stress or endothelial dysfunction.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: December 20, 2016
    Assignee: Radikal Therapeutics Inc.
    Inventors: Prakash Jagtap, Andrew Lurie Salzman
  • Multifunctional nitroxide derivatives and uses thereof
    Patent number: 9102659
    Abstract: Multifunctional nitroxide derivatives comprising a potassium channel opener and a reactive oxygen species (ROS) degradation catalyst that can act as an anti-oxidant, as well as pharmaceutical compositions comprising them are provided. The multifunctional compounds and pharmaceutical compositions are useful for treatment of diseases, disorders or conditions associated with oxidative stress or endothelial dysfunction.
    Type: Grant
    Filed: December 8, 2011
    Date of Patent: August 11, 2015
    Assignee: RADIKAL THERAPEUTICS INC.
    Inventors: Prakash Jagtap, Andrew Lurie Salzman
  • MULTIFUNCTIONAL NITROXIDE DERIVATIVES AND USES THEREOF
    Publication number: 20130338146
    Abstract: Multifunctional nitroxide derivatives comprising a potassium channel opener and a reactive oxygen species (ROS) degradation catalyst that can act as an anti-oxidant, as well as pharmaceutical compositions comprising them are provided. The multifunctional compounds and pharmaceutical compositions are useful for treatment of diseases, disorders or conditions associated with oxidative stress or endothelial dysfunction.
    Type: Application
    Filed: December 8, 2011
    Publication date: December 19, 2013
    Applicant: RADIKAL THERAPEUTICS INC.
    Inventors: Prakash Jagtap, Andrew Lurie Salzman
  • LIPOIC ACID AND NITROXIDE DERIVATIVES AND USES THEREOF
    Publication number: 20130116284
    Abstract: Provided are bifunctional compounds comprising a poly(ADP-ribose) polymerase (PARP) inhibitor moiety and a reactive oxygen species (ROS) scavenger moiety, more particularly, a lipoic acid or cyclic nitroxide derivative, covalently attached either directly or via a linker, as well as pharmaceutical compositions comprising them. The compounds and pharmaceutical compositions are useful for prevention, treatment, or management of diseases, disorders and conditions associated with elevated PARP activity or expression.
    Type: Application
    Filed: May 9, 2011
    Publication date: May 9, 2013
    Applicant: RADIKAL THERAPEUTICS INC.
    Inventor: Andrew Lurie Salzman