Patents Assigned to Radius Health, Inc.
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Patent number: 11255842Abstract: The present disclosure is directed to methods (e.g., in vitro methods) for detecting the presence of neutralizing antibodies to PTH or PTHrP analog in a sample. The in vitro method comprises the steps of obtaining a sample from a subject; contacting the sample with a cell; measuring cyclic adenosine monophosphate (cAMP) levels; and detecting the presence of neutralizing antibodies when cAMP levels are reduced relative to a negative control sample without neutralizing antibodies. An in vitro method of detecting the presence of neutralizing antibodies in a sample from a subject treated with Abaloparatide, is also provided. Further provided herein is a kit for carrying out the methods described herein comprising components required to carry out the obtaining, contacting, measuring and detecting steps and instructions for use.Type: GrantFiled: July 7, 2021Date of Patent: February 22, 2022Assignee: Radius Health, Inc.Inventor: Heidi K. Chandler
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Publication number: 20220003736Abstract: Provided herein are newly discovered methods of analyzing abaloparatide samples for abaloparatide isomers. Additionally, methods of storing and treating with abaloparatide in view of the newly discovered abaloparatide isomers are described.Type: ApplicationFiled: April 1, 2021Publication date: January 6, 2022Applicant: Radius Health, Inc.Inventors: Greg Williams, Naveen Palwai, David Hanley
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Publication number: 20210389300Abstract: The present disclosure is directed to methods (e.g., in vitro methods) for detecting the presence of neutralizing antibodies to PTH or PTHrP analog in a sample. The in vitro method comprises the steps of obtaining a sample from a subject; contacting the sample with a cell; measuring cyclic adenosine monophosphate (cAMP) levels; and detecting the presence of neutralizing antibodies when cAMP levels are reduced relative to a negative control sample without neutralizing antibodies. An in vitro method of detecting the presence of neutralizing antibodies in a sample from a subject treated with Abaloparatide, is also provided. Further provided herein is a kit for carrying out the methods described herein comprising components required to carry out the obtaining, contacting, measuring and detecting steps and instructions for use.Type: ApplicationFiled: July 7, 2021Publication date: December 16, 2021Applicant: Radius Health, Inc.Inventor: Heidi K. Chandler
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Publication number: 20210379162Abstract: Provided herein are methods for treating osteoporosis and increasing bone mass density, that includes administering once a day, for about 5 minutes, a transdermal patch loaded with about 300 ?g of abaloparatide, and ZnCl2 at a molar ratio of 2.2:1 of ZnCl2:abaloparatide. Also provided are the single-use transdermal patches loaded with about 300 ?g of abaloparatide, and ZnCl2 at a molar ratio of 2.2:1 of ZnCl2:abaloparatide.Type: ApplicationFiled: August 6, 2021Publication date: December 9, 2021Applicants: Radius Health, Inc., Kindeva Drug Delivery L.P.Inventors: Kenneth Brown, Ehab Hamed, Alan Harris, Gary Hattersley, Joan Moseman, Jamal Saeh, Lisa Dick
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Publication number: 20210369816Abstract: Disclosed are abaloparatide formulations for transdermal delivery of a therapeutically effective amount of abaloparatide, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.Type: ApplicationFiled: March 23, 2021Publication date: December 2, 2021Applicants: Radius Health, Inc., Kindeva Drug Delivery L.P.Inventors: Gary Hattersley, Alan Harris, Jamal Saeh, Ehab Hamed, Kenneth Brown, Daniel Dohmeier, Joan Moseman, Ying Zhang, Lisa Dick
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Patent number: 10996208Abstract: Provided herein are newly discovered methods of analyzing abaloparatide samples for abaloparatide isomers. Additionally, methods of storing and treating with abaloparatide in view of the newly discovered abaloparatide isomers are described.Type: GrantFiled: August 28, 2019Date of Patent: May 4, 2021Assignee: Radius Health, Inc.Inventors: Greg Williams, Naveen Palwai, David Hanley
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Patent number: 10980862Abstract: Disclosed are abaloparatide formulations for transdermal delivery of a therapeutically effective amount of abaloparatide, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.Type: GrantFiled: January 3, 2020Date of Patent: April 20, 2021Assignees: Radius Health, Inc., Kindeva Drug Delivery L.P.Inventors: Gary Hattersley, Alan Harris, Jamal Saeh, Ehab Hamed, Kenneth Brown, Daniel Dohmeier, Joan Moseman, Ying Zhang, Lisa Dick
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Publication number: 20210052705Abstract: The present invention provides compositions, devices, methods and processes related to the intradermal delivery of PTHrP and PTHrP analogues, particularly [Glu22,25, Leu23,28,31, Aib29, Lys26,30]hPTHrP(1-34)NH2.Type: ApplicationFiled: August 31, 2020Publication date: February 25, 2021Applicants: Radius Health, Inc., Kindeva Drug Delivery L.P.Inventors: Gary Hattersley, Kris J. Hansen, Amy S. Determan, Ying Zhang
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Publication number: 20200376088Abstract: Disclosed herein are PTHrP or analogues thereof, such as abaloparatide, for preventing or reducing bone fractures in subjects in need thereof, as well as methods of using PTHrP or analogues thereof to prevent or reduce bone fractures. Also disclosed are PTHrP or analogues thereof, such as abaloparatide, for increasing BMD and/or TBS in subjects in need thereof, as well as methods of using PTHrP or analogues thereof to increase BMD and/or TBS.Type: ApplicationFiled: June 16, 2020Publication date: December 3, 2020Applicant: Radius Health, Inc.Inventor: Gary Hattersley
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Publication number: 20200164045Abstract: Disclosed are abaloparatide formulations for transdermal delivery of a therapeutically effective amount of abaloparatide, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.Type: ApplicationFiled: January 3, 2020Publication date: May 28, 2020Applicants: Radius Health, Inc., 3M Innovative Properties CompanyInventors: Gary Hattersley, Alan Harris, Jamal Saeh, Ehab Hamed, Kenneth Brown, Daniel Dohmeier, Joan Moseman, Ying Zhang, Lisa Dick
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Publication number: 20200061160Abstract: Disclosed herein are PTHrP or analogues thereof, such as abaloparatide, for preventing or reducing bone fractures in subjects in need thereof, as well as methods of using PTHrP or analogues thereof to prevent or reduce bone fractures. Also disclosed are PTHrP or analogues thereof, such as abaloparatide, for increasing BMD and/or TBS in subjects in need thereof, as well as methods of using PTHrP or analogues thereof to increase BMD and/or TBS.Type: ApplicationFiled: September 10, 2019Publication date: February 27, 2020Applicant: Radius Health, Inc.Inventor: Gary Hattersley
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Patent number: 10568937Abstract: Disclosed are abaloparatide formulations for transdermal delivery of a therapeutically effective amount of abaloparatide, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.Type: GrantFiled: April 6, 2017Date of Patent: February 25, 2020Assignees: Radius Health, Inc., 3M Innovative Properties CompanyInventors: Gary Hattersley, Alan Harris, Jamal Saeh, Ehab Hamed, Kenneth Brown, Daniel Dohmeier, Joan Moseman, Ying Zhang, Lisa Dick
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Publication number: 20200057041Abstract: Provided herein are newly discovered methods of analyzing abaloparatide samples for abaloparatide isomers. Additionally, methods of storing and treating with abaloparatide in view of the newly discovered abaloparatide isomers are described.Type: ApplicationFiled: August 28, 2019Publication date: February 20, 2020Applicant: Radius Health, Inc.Inventors: Greg Williams, Naveen Palwai, David Hanley
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Publication number: 20190290738Abstract: The present invention provides compositions, devices, methods and processes related to the intradermal delivery of PTHrP and PTHrP analogues, particularly [Glu22,25, Leu23,28,31, Aib29, Lys26,30]hPTHrP(1-34)NH2.Type: ApplicationFiled: February 19, 2019Publication date: September 26, 2019Applicants: Radius Health, Inc., 3M Innovative Properties Company, a wholly owned subsidiary of 3M CompanyInventors: Gary Hattersley, Kris J. Hansen, Amy S. Determan, Ying Zhang
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Patent number: 9555014Abstract: This invention relates to clinically useful therapeutic regimens comprising the administration of (R)-6-(2-(ethyl(4-(2-(ethylamino)ethyl)benzyl)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol.Type: GrantFiled: May 19, 2014Date of Patent: January 31, 2017Assignee: Radius Health, Inc.Inventors: Louis O'Dea, C. Richard Lyttle, Jonathan Guerriero
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Publication number: 20160022608Abstract: This invention relates to clinically useful therapeutic regimens comprising the administration of (R)-6-(2-(ethyl(4-(2-(ethylamino)ethyl)benzyl)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol.Type: ApplicationFiled: May 19, 2014Publication date: January 28, 2016Applicant: Radius Health, Inc.Inventors: Louis O'Dea, C. Richard Lyttle, Jonathan Guerriero
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Patent number: 9133182Abstract: This invention provides compounds of formula I, pharmaceutical compositions comprising a compound of formula I and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type 2 diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds and intermediates useful in the preparation of same.Type: GrantFiled: September 27, 2011Date of Patent: September 15, 2015Assignee: Radius Health, Inc.Inventor: Chris P. Miller
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Patent number: 8987319Abstract: This invention provides compounds of Formula (I), (Ia), (Ib), (Ic), (II), (IIa) or (III) and or salts thereof, pharmaceutical compositions comprising a compound of Formula (I), (Ia), (Ib), (Ic), (II), (IIa) or (III) and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type II diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds of Formula (I), (Ia), (Ib), (Ic), (II), (IIa) or (III) and intermediates useful in the preparation of same.Type: GrantFiled: February 4, 2011Date of Patent: March 24, 2015Assignee: Radius Health, Inc.Inventor: Chris P. Miller
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Patent number: 8933130Abstract: The present invention is directed toward methods for treating vasomotor symptoms, (e.g., hot flashes and night sweats) in a patient in need thereof comprising administering a SERM as described herein.Type: GrantFiled: June 22, 2007Date of Patent: January 13, 2015Assignee: Radius Health, Inc.Inventors: C. Richard Lyttle, Bart Henderson, Gary Hattersley
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Patent number: 8748382Abstract: The present invention provides a storage-stable composition containing a parathyroid hormone-related protein (PTHrP) and methods of using a PTHrP and the PTHrP compositions described herein to treat osteoporosis, to increase bone mass or to increase bone quality. The composition is storage stable, in sterile form, and in general may be stored at room temperature for at least several weeks to allow convenient parenteral administration to human patients.Type: GrantFiled: April 3, 2012Date of Patent: June 10, 2014Assignees: Radius Health, Inc., Ipsen Pharma S.A.S.Inventors: Michael J. Dey, Nathalie Mondoly, Benedicte Rigaud, Bart Henderson, C. Richard Lyttle