Abstract: Methods and apparatus for analysis of a sample using Raman spectroscopy, which employs a multi-mode radiation source and a spectral filter, are disclosed. The source radiation produces a Raman spectrum consisting of scattered electromagnetic radiation that is separated into different wavelength components by a dispersion element. A detection array detects a least some of the wavelength components of the scattered light and provides data to a processor for processing the data. The resulting spectroscopic data has higher resolution and stability than conventional low-resolution Raman systems.

Abstract: Methods and apparatus for in vitro detection of an analyte in a blood sample using low resolution Raman spectroscopy are disclosed. The blood analyzer includes a disposable strip for receiving a sample of blood on a target region, the target region including gold sol-gel to provide surface enhanced Raman scattering. A light source irradiates the target region to produce a Raman spectrum consisting of scattered electromagnetic radiation that is separated into different wavelength components by a dispersion element. A detection array detects a least some of the wavelength components of the scattered light and provides data to a processor for processing the data. The results of the processed data are displayed on a screen to inform a user about an analyte within the blood sample.

Abstract: Raman spectroscopy probe assemblies are disclosed for use with portable and/or handheld analyzers. The probes are also adaptable to sample liquids, and/or powders, tablets and/or other solids and are capable of withstanding harsh environmental conditions. The probes include an optical head assembly, associated optical fibers and replaceable sampling tubes. In one aspect of the invention, a simple orthogonal optical head assembly is disclosed that does not require collinear optical paths. The orthogonal arrangement of input and captured light paths also reduces the need for precise alignment of the optical components. The orthogonal optical head assemblies of the present invention are well suited to accommodate the shutoff mechanisms of the present invention. In another aspect of the invention, sampling tubes, and replaceable end caps for such tubes, are disclosed that facilitate hand measurements of substances.