Patents Assigned to Ramareddy V. Guntaka
  • Oligmers which inhibit expression of collagen genes
    Patent number: 6156513
    Abstract: Oligomers which inhibit expression of a collagen gene are described. It is believed that each oligomer, when introduced into a cell, forms a transcription-inhibiting complex composed of the oligomer and the collagen-gene promoter region. The oligomer, preferably a phosphorothioate deoxyoligonucleotide or a ribonucleotide, preferably binds in the antiparallel orientation to the polypurine strand of a polypurine-polypyrimidine region of the promoter region of a mammalian .alpha.1(I) collagen gene.
    Type: Grant
    Filed: August 7, 1998
    Date of Patent: December 5, 2000
    Assignee: Ramareddy V. Guntaka
    Inventors: Ramareddy V. Guntaka, Karl T. Weber, Attilla Kovacs, Jagannadhachari Kandala