Abstract: A polymeric nanoparticle is disclosed which comprises: (i) at least one SARS-CoV-2 derived antigen which is capable of producing a T-cell and/or B cell response: and (ii) an antigen presenting cell targeting moiety which is attached to the outer surface of the nanoparticle. Use of the nanoparticle for treating COVID-19 is also disclosed.

Abstract: A three dimensional (3D) model of a glioblastoma tumor made of a synthetic material and a plurality of cell types, including malignant cells and non-malignant cells of the tumor. Methods of forming the 3D tumor model are also provided, as well as systems in which the 3D tumor model can be perfused and fluidly connected to a medium containing immune cells and/or other cells and factors present in the tumor's microenvironment. Methods utilizing the 3D tumor model or the system in, for example, personalized therapy, are also provided.

Abstract: Methods which utilize a self-assembled structure formed of a plurality of peptides being of from 2 to 6 amino acids in length, and comprising at least one aromatic amino acid residue, wherein the self-assembled structure is capable of interacting with oxygen, are provided herewith. The methods may be for controlling (e.g., reducing) a concentration of free oxygen in an environment, and/or for transporting oxygen from a first environment to a second environment. Further described herein is a self-assembled structure as described herein having oxygen interacted therewith. Further described herein is a composition comprising the self-assembled structure and substance which is oxygen-sensitive and/or participates in an oxygen-sensitive reaction incorporated in the self-assembled structure, systems comprising such a composition and methods employing the composition or system.

Abstract: Device for concentration of bioparticles for identification comprises one or more capillary flow paths from at least one inlet for advection along the path of bioparticles in a buffer solution, two or more membranes along the flow path, the membranes being individually selectable for electrical powering, thereby to controllably set up a powered membrane region at a location along said path, said powered membrane region causing localized concentration of the bioparticles, digital-like manipulation of the preconcentrated bioparticles plugs, and detection surface immobilized molecular probes located along said flow path to detect the bioparticles following localized concentration.

Abstract: A method of synthesizing a magnetic resonance (MR) image, comprises obtaining a quantitative MRI (qMRI) map of values of an MRI parameter, modulating values of the MRI parameter within a region of the qMRI map to mimic a tissue pathology therein, and generating an MR image based on the modulated qMRI map.

Abstract: Apparatus for protection of electronics in a radiation-prone environment from incoming particles that may cause damage, comprises one or more radiation-detecting layers extending at least partially over one or more sides of a radiation-sensitive electronic device that needs protection, the radiation-detecting layer being configured to obtain an estimate of a characteristic, such as the LET (linear energy transfer), of the incoming particle, A stress assessment unit determines whether the measured characteristic implies a threat to the radiation-sensitive electronic device, and if it does, then a protection module associated with the stress-assessment unit powers down all or part of the radiation-sensitive electronic device within a predetermined time after the incoming particle has been detected, thereby to protect the radiation sensitive electronic device from damage due to the detected particle. The power down is typically completed within a short enough time to avoid damage.

Abstract: A system for training a quantized neural network dataset, comprising at least one hardware processor adapted to: receive input data comprising a plurality of training input value sets and a plurality of target value sets; in each of a plurality of training iterations: for each layer, comprising a plurality of weight values, of one or more of a plurality of layers of a neural network: compute a set of transformed values by applying to a plurality of layer values one or more emulated non-uniformly quantized transformations by adding to each of the plurality of layer values one or more uniformly distributed random noise values; and compute a plurality of output values; compute a plurality of training output values; and update one or more of the plurality of weight values to decrease a value of a loss function; and output the updated plurality of weight values of the plurality of layers.

Abstract: There is described an integrated antenna for radiating an electromagnetic beam at a wavelength ?, for example, in a range of millimeter and submillimeter waves. The antenna is integrated in a dielectric die having specific dimensions, and is configured as a dense array comprising two or more radiating elements (transmitters). The proposed array is denser than a conventional 1D or 2D array, would such a conventional array be arranged on the same dielectric die with a spacing ?/2 between its neighbouring radiating elements.

Abstract: Provided herein are methods for EEG monitoring of a patient, which includes: positioning an array comprising a plurality of EEG electrodes on the patient's head; recording, during a first time period, a first data set of EEG signals from a first set of spatial scalp locations; manipulating the array to record, during a second time period, a second data set of EEG signals from a second set of spatial locations including at least some spatial scalp locations that are different from the first set of spatial scalp locations; integrating the first and second data sets, thereby generating a combined data set with a higher spatial density; and processing the combined data set to determine EEG events.

Abstract: Techniques for generating and managing, including simulating and training, deep tensor neural networks are presented. A deep tensor neural network comprises a graph of nodes connected via weighted edges. A network management component (NMC) extracts features from tensor-formatted input data based on tensor-formatted parameters. NMC evolves tensor-formatted input data based on a defined tensor-tensor layer evolution rule, the network generating output data based on evolution of the tensor-formatted input data. The network is activated by non-linear activation functions, wherein the weighted edges and non-linear activation functions operate, based on tensor-tensor functions, to evolve tensor-formatted input data. NMC trains the network based on tensor-formatted training data, comparing output training data output from the network to simulated output data, based on a defined loss function, to determine an update.

Abstract: Systems and methods for visualizing an unstained sperm cell are presented, the system comprises a data input utility that receives measured data comprising at least one quantitative phase microscopy image of the unstained sperm cell; a data processing utility comprising an image analyzer module that utilizes characteristic refractive index information of one or more organelles of the sperm cell, to process the at least one quantitative phase microscopy image and generate at least one corresponding gradient image that includes edge enhancement of the one or more organelles, and a virtual staining module that applies one or more predetermined virtual staining functions to the at least one quantitative phase microscopy image and at least one corresponding gradient image, thereby virtually stain at least one of the one or more organelles of the sperm cell and generate virtually stained image data of the sperm cell; and an output utility that utilizes the virtually stained image data of the sperm cell and generate

Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.

Abstract: The present invention provides dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.

Abstract: A method for robust state manipulation in quantum information processing comprises evanescently coupling a first waveguide to a second waveguide, the first and second waveguide having different geometries respectively; and providing waveguide geometries such that their coupling is detuned, the detuning being a function of the geometries, the detuned coupling thereby providing reliable population transfer between the first and second waveguides that is robust to fabrication and other errors. The method may be used to provide a quantum optical coupler.

Abstract: Disclosed are methods and devices useful for imaging blood-containing tissue, for example for angiography, especially retinal angiography, whereby an image is generated by dividing pixels of an image acquired at some wavelength range by corresponding pixels of an image acquired at a different wavelength range. In some embodiments, a first wavelength range includes predominantly light having wavelengths between about 400 nm and about 620 nm and a second wavelength range includes predominantly light having wavelengths between about 620 nm and about 800 nm.

Abstract: A method for constructing a quantum gate for a unitary operation in photonic quantum information processing, comprises: providing two or more waveguides, calculating segment parameters for segments within a coupling region, said one or more parameters relating to propagation constants of respective waveguides, said one or more parameters being different for said first and second waveguides respectively and thereby providing detuning between said first and second waveguides to allow for unitary operation between said first and second waveguides with high fidelity in the presence of errors, then building the segments into the respective waveguides and optically coupling the waveguides at the coupling region using the segment parameters, thereby to construct a quantum logic gate for a unitary operation.

Abstract: A sensing system and a method utilizing same for determining and/or monitoring a presence and/or level of an analyte in a sample are provided. The sensing system is made of a nanostructure, or a plurality of nanostructures, having covalently attached thereto and a hydrogel having associated therewith a sensing moiety which selectively interacts with the analyte and being configured such that upon contacting the analyte, the nanostructure(s) exhibit a detectable change in an electrical property.

Abstract: A new family of mononuclear organometallic complexes of a divalent metal bound to sequential tetradentate monoanionic {ONNN}-type ligands, and polymerization of cyclic esters such as lactides utilizing same are provided. Novel tetradentate monoanionic {ONNN}-type ligands usable for forming these complexes are also provided.

Abstract: Compounds represented by general Formulae I to IV as described herein are disclosed. Further disclosed are composition utilizing the herein disclosed compounds and using the same for the treatment of glycogen storage disorders.