Abstract: The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.

Abstract: In a system for converting digital data into a modulated optical signal, an electrically controllable device, including a modulator having one or more actuating electrodes, provides an analog-modulated optical signal that is modulated in response to output data bits of a digital-to-digital mapping. A digital-to-digital conversion provides the mapping of input data words to the output data bits. The mapping enables adjustments to correct for non-linearities and other undesirable characteristics, thereby improving signal quality.

Abstract: An effective therapeutic agent for the M2 channel comprising sulfonylamide or oxabicyclo structures effective for treating amantadine-resistant influenza A infections, and methods of treating amantadine-resistant influenza A infections through administration of the same.

Abstract: The present invention provides cationic pillar[n]arenes, e.g., positively charged poly-ammonium, poly-phosphonium and poly-imidazolium pillar[5-6]arene derivatives, capable of inhibiting or preventing biofilm formation, and facilitating existing biofilm decomposition; as well as compositions thereof and methods of use.

Abstract: There is provided a Kramers-Kronig receiver, comprising a reception path; wherein the reception path comprises: a Stokes receiver that is configured to receive a polarization-multiplexed signal and to output a Stokes vector; wherein the polarization-multiplexed signal comprises a first modulated signal, a second modulated signal and a continuous wave signal; wherein the first modulated signal is of a first polarization; wherein the second modulated signal is of a second polarization; wherein the continuous wave signal is of the first modulation or of the second modulation; a set of analog to digital converters that are configured to generate a digital representation of the Stokes vector; and a digital processor that is configured to process the digital representation of the Stokes vector to provide a reconstructed polarization-multiplexed signal, wherein the processing is based on a Kramers-Kronig relationship related to the polarization-multiplexed signal.

Abstract: The present invention relates to vaccine compositions comprising attenuated strain of Tilapia Lake Virus (TiLV) for protecting tilapia fish against infection by (TiLV). The invention also relates to methods for using the vaccines to protect tilapines from TiLV-induced disease.

Abstract: Methods for treating and reducing risk of cerebral amyloid angiopathy (CAA) using nasal vaccination with a proteosome adjuvant.

Abstract: Monochromatic cameras and methods for using such cameras to obtain a still or video color image of an object or scene. The image sensor of such cameras is clear, without a color filter array. A diffused-dispersed and optionally randomized image of the object or scene obtained at the image sensor is processed directly into a number R<K of spectral images in R wavebands. K?R spectral images are interpolated from the R spectral images. A color image is then reconstructed using the directly processed R spectral images and the K?R interpolated spectral images. The interpolated images may exemplarily be obtained using a spline subdivision algorithm.

Abstract: A method of determining tyrosinase activity of a cell is disclosed. The method comprises: (a) contacting the cell with a phenol under conditions wherein tyrosinase of the cell catalyzes a reaction with said phenol, so as to generate a product which produces an electrical signal; and (b) measuring a level of the electrical signal, thereby determining tyrosinase activity of the cell. Use of the method for detecting melanoma in skin samples is also disclosed.

Abstract: A device for optical sensing of substances or environmental conditions in a fluid includes a number of non-overlapping adjacent sensing elements, each having a layered optical element for generating a wavelength-specific interference effect and being treated so as to respond to the presence of a predefined substance or a predefined environmental condition to cause an optically detectable change. The sensing elements are distinct from each other both in their wavelength-specific interference effect and in the corresponding optically detectable change. As a result, when the device is illuminated by a common illumination beam of multi-wavelength illumination, spectral analysis performed on the reflected or transmitted illumination enables simultaneous sensing of a plurality of substances or environmental conditions. In certain preferred implementations, the layered optical element includes at least one layer of porous silicon.

Abstract: A bipolar plate and regenerative fuel cell stacks including the bipolar plates and membrane electrode assemblies (MEAs) alternately stacked. The bipolar plate comprises a plate main body formed of an electrically conductive material. The plate main body has a first surface and a second surface opposite the first surface. Each surface has reaction flow channels through which fluids pass. The reaction flow channels on the first surface have a plurality of ribs therebetween forming an interdigitate flow field pattern. The reaction flow channels on the second surface have a plurality of ribs therebetween forming an interdigitate flow field pattern or a flow field pattern different from an interdigitate flow field pattern, e.g., a serpentine flow field pattern.

Abstract: This invention provides a method for producing bioactive coral bone graft substitutes and to products obtained thereby.

Abstract: The present invention provides pharmaceutical compositions comprising substituted 1,4 naphthoquinones that are effective in preventing oligomerization of beta amyloid and subsequent pathologies associated with amyloid fibrils. These compositions are useful for the treatment of disease involving amyloidogenesis including neurodegenerative diseases such as Alzheimer's Disease or senile dementia. Particularly effective compositions comprise 1,4 naphthoquinones substituted with an amino acid residue selected from a heterocyclic or aromatic amino acid.

Abstract: A pharmaceutical composition containing a therapeutic protein which is particularly amenable to oral administration by providing stability in the gastrointestinal tract. Insoluble fibrils or aggregates of the therapeutic protein in the pharmaceutical composition are encapsulated in a lipidated glycosaminoglycan particle, coated with a multi-layer of lipids and lipid-glycosaminoglycan conjugates, or present as unencapsulated and uncoated insoluble fibrils or aggregates.

Abstract: A searchable protein database is disclosed. The protein database comprises a plurality of entries, each entry having a sufficiently short predicting sequence and a protein classifier corresponding to the predicting sequence. An unclassified protein sequence can be classifiable by the database via searching therein for a motif of amino acids matching a predicting sequence of the database, thereby attributing to the unclassified protein a protein classifier.

Abstract: A hybridoma cell which has been deposited under ATCC Accession Number PTA-9974 is disclosed. Also provided are Antibodies and methods of using same.

Abstract: A system and method for improving conversion efficiency of a difference frequency generator (DFG) and/or for outputting a desired shape of the output signal, where the method includes providing a pump source, modifying the pump pulse temporal shape for optimal DFG conversion efficiency, and providing the modified pump pulse to the DFG. The pump source may be, for example, a MOPA laser or a diode or any other suitable source. In one embodiment, the pump pulse shape is modified such that an initial gain within the DFG is high, followed by a lower level signal for efficient conversion within the DFG. An example of such a shape is a double square pulse. Other configurations are possible as well such as a single rectangular pulse shape.

Abstract: To decode a representation, imported from a channel, of a codeword that encodes K information bits as N>K codeword bits, estimates of the codeword bits are updated by exchanging messages between N bit nodes and N?K check nodes of a graph in a plurality of iterations. In each of one or more of the iterations, some or all values associated with the bit nodes, and/or some or all values associated with check nodes, and/or some or all messages are modified in a manner that depends explicitly on the ordinality of the iteration and is independent of any other iteration. Alternatively, the modifications are according to respective locally heteromorphic rules.

Abstract: Input bits are stored in memory cells by mapping the input bits into a larger number of transformed bits using a shaping encoding that has a downward asymptotic bias with respect to a mapping of bit patterns to cell states and programming some of the cells according to that mapping of bit patterns to cell states. The programmed cells are erased before being programmed to store any other bits. The invention sacrifices memory capacity to increase endurance.

Abstract: A plurality of information bits are encoded using a parity-check matrix that is equivalent to a modular code matrix. The modular code matrix is a diagonal sub-matrix structure immediately above a connection layer that includes a plurality of diverse connection layer sub-matrices, all but at most one of which are below corresponding diagonal matrix structure sub-matrices. The information bits are assembled with a plurality of parity bits produced by the encoding to provide a codeword that is exported to a medium. Preferably, all the diagonal matrix structure sub-matrices are identical. Preferably, some of the parity bits are computed using only diagonal matrix structure sub-matrices.