Patents Assigned to Ramot of Tel Aviv University
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Patent number: 12373528Abstract: A method of identifying a person, the method comprising: acquiring spatiotemporal data for each of a plurality of anatomical landmarks associated with an activity engaged in by a person that defines a spatiotemporal trajectory of the anatomical landmark during the activity; modeling the acquired spatiotemporal data as a spatiotemporal graph (ST-Graph); and processing the ST-Graph using at least one non-local graph convolution neural network (NLGCN) to provide an identity for the person.Type: GrantFiled: July 30, 2021Date of Patent: July 29, 2025Assignee: Ramot at Tel-Aviv University Ltd.Inventors: David Mendlovic, Menahem Koren, Lior Gelberg, Khen Cohen, Mor-Avi Azulay, Ohad Volvovitch
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Publication number: 20250237789Abstract: An antireflective coating for reducing reflection of a wave off the coating, comprises a stack of layers, each having a discrete array of resonators characterized by a resonant wavelength within a spectral band of the wave, wherein at least two layers are characterized by different resonant wavelengths such that a set of resonant wavelengths of all layers discretely spans over the spectral band.Type: ApplicationFiled: October 28, 2022Publication date: July 24, 2025Applicant: Ramot at Tel-Aviv University Ltd.Inventor: Jacob SCHEUER
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Patent number: 12365794Abstract: This invention is directed to nanocomposite comprising biodegradable polymers and inorganic nanoparticles or nanotubes, methods of preparation and uses thereof.Type: GrantFiled: December 26, 2019Date of Patent: July 22, 2025Assignees: Yeda Research and Development Co. Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Reshef Tenne, Hila Shalom, Noa Lachman Senesh
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Patent number: 12360204Abstract: A cloaking and/or deception system comprises: a structure having a plurality of resonators characterized by a controllable resonance frequency, wherein the resonators are arranged to collectively ensure that variation of the resonance frequency over a predetermined range of resonance frequencies generates a phase shift between the an electromagnetic wave incident on the structure and an electromagnetic wave scattered off the structure; and a controller configured for controlling the resonance frequency to provide a time-varying resonance frequency characterized by a temporal function which comprises a linear time-dependence.Type: GrantFiled: April 16, 2021Date of Patent: July 15, 2025Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Pavel Ginzburg, Vitali Kozlov, Dmytro Vovchuk
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Publication number: 20250223650Abstract: A method of detecting the level of 5-hydroxymethylcytosines (5-hmc) in a DNA molecule of a cell having a 5-hmc prevalence lower than 0.002% of total DNA bases is provided. The method comprising: (a) attaching a 5-hmc labeling agent to the DNA molecule; and (b) subjecting the DNA molecule to an imaging method suitable for detecting the labeling agent, thereby detecting the level of 5-hmc in the DNA molecule. Also provided is a method of diagnosing cancer in a subject in need thereof, the method comprising: (a) providing a DNA sample of a cell of the subject; (b) detecting the level of 5-hmc in the DNA sample as described herein; wherein a significant decrease in the level of 5-hmc in the DNA sample, as compared to a control DNA sample from a healthy subject is indicative that the subject has cancer.Type: ApplicationFiled: August 12, 2024Publication date: July 10, 2025Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Yuval EBENSTEIN, Shahar ZIRKIN, Yael MICHAELI HOCH
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Publication number: 20250214982Abstract: Newly designed compounds represented by Formulae I-V as described in the instant specification and uses thereof as pancreatic endoplasmic reticulum kinase (PERK) activators and in treating associated medical conditions, including viral infections, are provided.Type: ApplicationFiled: March 29, 2023Publication date: July 3, 2025Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Gerardo Zelmar LEDERKREMER, Marcelo EHRLICH, Marina SHENKMAN, Elvira HAIMOV
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Publication number: 20250205230Abstract: Compounds capable of activating an unfolded protein response (UPR) in a cell, for use in treating a viral infection in a subject in need thereof, are disclosed. The compounds can be PERK activators and/or compounds represented by Formula I as described in the specification.Type: ApplicationFiled: March 29, 2023Publication date: June 26, 2025Applicants: Ramot at Tel-Aviv University Ltd., The Regents of The University of CaliforniaInventors: Gerardo Zelmar LEDERKREMER, Marcelo EHRLICH, Marina SHENKMAN, Elvira HAIMOV, Raul ANDINO-PAVLOVSKY, Yinghong XIAO, Ranen AVINER, Petr V. LIDSKIY
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Publication number: 20250179166Abstract: A method of activating an immune response against brain metastasis in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of an inhibitor of an MCP-1/CCR2/CCR4 axis, thereby activating the immune response against brain metastasis in the subject.Type: ApplicationFiled: January 28, 2025Publication date: June 5, 2025Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Ronit SATCHI-FAINARO, Sabina POZZI, Sahar ISRAELI DANGOOR
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Publication number: 20250171821Abstract: Method of increasing collagen production and tissue regeneration or repair using an agent that increases an amount of Hypoxia-inducible factor-1 (HIF-1) in the cells, the amount being selected to cause an increase in the amount of collagen production in the cells are disclosed. Also disclosed non-human cell cultures which comprise an activator of HIF-1.Type: ApplicationFiled: February 10, 2025Publication date: May 29, 2025Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Maayan GAL, Evgeny WEINBERG, Lihi ADLER-ABRAMOVICH, Ran TOHAR
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Patent number: 12311075Abstract: A spherical particle comprising decellularized omentum being between 1 nM-300 ?M in diameter is disclosed. In some embodiments, the particle comprises biological cells. In other embodiments, the particle comprises a biomolecule. Uses of the particles are also disclosed.Type: GrantFiled: January 3, 2022Date of Patent: May 27, 2025Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Tal Dvir, Assaf Shapira, Michal Shevach, Idan Gal
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Publication number: 20250163128Abstract: A T cell expressing an FC gamma receptor is provided. Accordingly there is provided a T cell genetically engineered to express a first polypeptide comprising an amino acid sequence of an Fc receptor common ? chain (FcR?), said amino acid sequence is capable of transmitting an activating signal; and a second polypeptide comprising an extracellular ligand-binding domain of an Fc? receptor capable of binding an Fc ligand and an amino acid sequence capable of recruiting said first polypeptide such that upon binding of said Fc ligand to said extracellular ligand-binding domain of said Fc? receptor said activating signal is transmitted.Type: ApplicationFiled: January 3, 2025Publication date: May 22, 2025Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Yaron CARMI, Peleg RIDER, Diana RASOULOUNIRIANA
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Patent number: 12296094Abstract: Pulmonary treatment methods and systems. During pulmonary treatment breath cycles, a hold period of elevated inspiration pressure may promote lung region filling (and potentially recruitment) via collateral airways. Expectoration is promoted by dropping from the inspiration pressure to an undershoot pressure; de-recruitment (e.g., by airway collapse) is mitigated by raising the undershoot pressure to a positive expiratory pressure (PEP) during expiration phase. Breath cycles with a period of post-PEP suction may also be administered. Respiratory therapy systems may be programmed or re-programmed to administer this pressure protocol.Type: GrantFiled: April 26, 2021Date of Patent: May 13, 2025Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Moshe Ashkenazi, Gil Sokol, Ori Efrati, Itzik Mashiach, Diana Sverdlov, Ortal Shtayman, Imry Ben Avi, Daniel Sorkin
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Publication number: 20250145942Abstract: Provided herein is a see-through transparent, stable, safe and (bio)degradable hydrogel-based particulate support medium, made of calcium alginate particles. The calcium alginate particles, or hybrid hydrogel particles, are characterized by a substantially homogeneous average particle size that ranges from 0.1 micrometer to 5 micrometer.Type: ApplicationFiled: January 3, 2025Publication date: May 8, 2025Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Tal DVIR, Assaf SHAPIRA
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Patent number: 12294387Abstract: Disclosed herein are systems and method for training neural network based decoders for decoding error correction codes, comprising obtaining a plurality of training samples comprising one or more codewords encoded using an error correction code and transmitted over a transmission channel where the training samples are subject to gradual interference over a plurality of time steps and associate the encoded codeword(s) with an interference level and a parity check syndrome at each of the plurality of time steps, using the training samples to train a neural network based decoder to decode codewords encoded using an error correction code by (1) estimating a multiplicative interference included in the encoded codeword(s) based on reverse diffusion applied to the encoded codeword(s) across the time steps, (2) computing an additive interference included in the encoded codewords based on the multiplicative interference, and (3) recovering the codeword(s) by removing the additive interference.Type: GrantFiled: July 18, 2023Date of Patent: May 6, 2025Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Yoni Choukroun, Lior Wolf
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Publication number: 20250107745Abstract: There is provided a method of diagnosing a medical state associated with a neuro-psychiatric disorder in a subject, comprising: receiving EEG datasets from EEG electrodes monitoring a head of the subject, computing events for the EEG datasets, clustering the events into clusters, computing a p-adic representation of the clusters, extracting a p-adic topology from the p-adic representation of the clusters, computing a personal universal dendrogramic holographic signature (PUDHS) of the p-acid topology relative to a personalized threshold that separates between a relative large distance between events and a relatively small distance between events, the PUDHS denoting number of events below the personalized threshold, and diagnosing the medical state associated with the neuro-psychiatric disorder according to the PUDHS relative to a medical threshold that separates between presence of the medical state and non-presence of the medical state.Type: ApplicationFiled: March 10, 2023Publication date: April 3, 2025Applicants: Ramot at Tel-Aviv University Ltd., Mor Research Applications Ltd.Inventors: Oded SHOR, Felix BENNINGER, Andrei KHRENNIKOV
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Publication number: 20250099503Abstract: The present disclosure describes a chimeric antigen receptors (CAR) that allow a cell of the B cell lineage to undergo antigen-induced activation independent of a cell of T cell lineage, compositions thereof, and method of use thereof for genetically modifying a cell of the B cell lineage or treating a subject suffering from a pathological disorder.Type: ApplicationFiled: January 25, 2023Publication date: March 27, 2025Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Adi BARZEL, Alessio D. NAHMAD, Rashad TARADI
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Publication number: 20250082766Abstract: A method of treating a brain tumor in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of an agent capable of downregulating activity or expression of a component of the lipid synthesis and/or transportation pathways in an astrocyte in the tumor microenvironment and/or a therapeutically effective amount of a molecule which is associated with lipid uptake by the tumor cells or immune cells in the tumor microenvironment, or a polynucleotide encoding same.Type: ApplicationFiled: September 26, 2024Publication date: March 13, 2025Applicant: Ramot at Tel-Aviv University Ltd.Inventor: Lior MAYO
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Patent number: 12236713Abstract: Systems, methods, and computer readable media for identifying a person in a video are disclosed. Systems, methods, devices, and non-transitory computer readable media may include at least one processor that may be configured to generate a spatiotemporal emotion data compendium (STEM-DC) from the video and to process the STEM-DC using a deep fully adaptive graph convolutional network (FAGC) to determine a first person representation vector that represents the person in the video.Type: GrantFiled: November 30, 2022Date of Patent: February 25, 2025Assignee: Ramot at Tel-Aviv University Ltd.Inventors: David Mendlovic, Dan Raviv, Lior Gelberg, Khen Cohen, Mor-Avi Azulay, Menahem Koren
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Publication number: 20250061999Abstract: A system which can be used for carrying out a method for determining an efficacy of a transcranial magnetic stimulation (TMS) treatment, including: delivering TMS to a patient using a TMS protocol in a TMS treatment session; recording EEG signals before and after the delivering during the treatment session; recording EEG signals after completion of the treatment session; analyzing the recorded EEG signals to generate values of one or more EEG parameters; determining an acute effect and an intermediate effect of the TMS protocol on a brain state of the patient based on a change in values of the one or more EEG parameters; determining an efficacy of the TMS protocol based on the determined acute effect and the intermediate effect.Type: ApplicationFiled: December 13, 2022Publication date: February 20, 2025Applicants: Mor Research Applications Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Amir GLIK, Miriam FURST-YUST, Felix BENNINGER
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Publication number: 20250057892Abstract: Provided are nucleic acid constructs, Toxoplasma comprising same, pharmaceutical compositions comprising same and methods using same for delivering a protein-of-interest to a tissue-of-interest of a subject, such as the CNS and further treating a pathology which is treatable by administration of a therapeutic polypeptide in a central nervous system of the subject.Type: ApplicationFiled: August 26, 2024Publication date: February 20, 2025Applicants: Ramot at Tel-Aviv University Ltd., The University Court of the University of GlasgowInventors: Oded RECHAVI, Shahar BRACHA, Lilach SHEINER