Abstract: A system including a display, an eye tracker, and a processor that executes the following: operate the display to present multiple objects to a user; operate the eye tracker to track an eye gaze of the user during the presentation of the multiple objects; calculate an estimated user preference of each of the multiple objects, by performing at least one of: (a) calculating a measure of central tendency of distances from a center of the respective object to points of the eye gaze on the respective object, wherein a higher measure of central tendency of the distances indicates a stronger user preference and vice versa, and (b) calculating a measure of central tendency of speeds of transition between temporally-consecutive ones of the points of the eye gaze, wherein a higher measure of central tendency of the speeds indicates a stronger user preference and vice versa.

Abstract: A method of scanning an object in a FOV by acquiring an MRI signal from the object at different projections of a spatially encoding magnetic field, using a plurality of receiving antennas, and reconstructing an MRI image of the object, comprising: a) at each projection, acquiring the MRI signal from the receiving antennas; b) filtering the received signal, for at least some of the projections, by applying different time windows to different components of the signal in different frequency bands, and/or received by different receiver antennas, resulting in a filtered received signal vector whose components describe the filtered received signal as a function of time, at each projection, for one or more receiver antennas; and c) reconstructing an image as a vector whose components describe a weighted or unweighted net magnetization at each voxel in the FOV, that would be expected to produce the filtered received signal vector.

Abstract: The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.

Abstract: A diagnostic system includes an array of electrodes, which are coupled to a body surface of a living subject at different, respective positions in proximity to a region of interest within the body. A switched impedance network applies varying loads to the electrodes. A processor is coupled to receive and measure electrical signals from the electrodes as a function of the varying loads, and to analyze the measured signals so as to compute a local electrical characteristic of one or more locations within the region of interest.

Abstract: Method for mapping the transverse relaxation times (T2) in a magnetic resonance imaging (MRI) scan defined over a plurality of pixels, where each pixel is associated with a multicomponent T2 (mcT2) signal, comprises: accessing a computer readable medium storing an mcT2 dictionary having a set of synthetic mcT2 signals, and selecting a subset of synthetic mcT2 signals for which correlations between the synthetic mcT2 signals and pixels in the MRI scan are highest among the set. For each of at least a portion of the pixels, a respective mcT2 scan signal is fitted to the subset to provide, a plurality of T2 values for the pixel. A T2 map of the MRI scan is generated based on the T2 values.

Abstract: Compounds (small molecules) capable of interfering with an interaction between PD-1 and PD-L1, and thereby are usable in treating cancer and/or in increasing T-cell function and/or in treating a medical condition associate with PD1, PD-L1 and/or T-cell function on cells, pharmaceutical compositions and kits comprising same and uses thereof, are provided.

Abstract: A system for polarization imaging comprises an optical diffuser characterized by a point spread function (PSF), an image sensor, a spatially multiplexed polarization filter between the optical diffuser and the image sensor, and an image processor. The image processor receives signals from the image sensor and reconstructs, based on the PSF, a separate image for each polarization direction formed on the polarization filter.

Abstract: Methods and kits for identifying an increased risk of developing preeclampsia in a pregnant woman based on expression pattern of non-coding RNAs in body fluids are provided. In particular, the methods provide information for identifying a pregnant woman as being at risk of developing preeclampsia by analyzing the pattern of non-coding RNAs in body fluids during early stages of pregnancy.

Abstract: There is provided a computer implemented method of diagnosing a medical state associated with a neuro-psychiatric disorder in a subject, comprising: receiving a plurality of EEG datasets, each respective EEG dataset from a respective EEG electrode of a plurality of EEG electrodes monitoring a head of the subject, clustering the plurality of EEG datasets into a plurality of clusters, computing a p-adic representation of the plurality of clusters, extracting a quantum potential value from p-adic representation of the plurality of clusters, and diagnosing the medical state associated with the neuro-psychiatric disorder according to the quantum potential relative to a threshold that separates between presence of the medical state and non-presence of the medical state.

Abstract: MAdCAM-1 polypeptides are provided. Accordingly there is provided a polypeptide comprising an amino acid sequence of MAdCAM-1 capable of binding alpha4beta7 integrin, wherein said polypeptide is in association with a therapeutic or a detectable moiety. Also provided are methods of treating and diagnosing inflammation mediated by MAdCAM-1.

Abstract: A method of diagnosing a condition of a subject, comprises: receiving image data of an anterior of an eye of the subject, and analyzing the image data to detect at least one of: flow of individual blood cells in libmal or conjunctival blood vessels of the eye, morphology of limbal or conjunctival blood vessels. The method also comprises determining the condition of the subject based on the detection(s).

Abstract: Methods for dehazing a digital image and for restoring an underwater digital image. The methods include the following steps: First, clustering pixels of a digital image into haze-lines, wherein each of the haze-lines is comprised of a sub-group of the pixels that are scattered non-locally over the digital image. Second, estimating, based on the haze-lines, a transmission map of the digital image, wherein the transmission map encodes scene depth information for each pixel of the digital image. Then, for a hazy image, calculating a dehazed digital image based on the transmission map.

Abstract: A composition-of-matter is described herein, comprising a first layer and third layer separated by a second layer. The first and third layers each comprise a thermoplastic polymer and a substance capable of reversibly releasing lithium or a delithiated form of the substance. The second layer comprises a thermoplastic polymer and is capable of conducting lithium ions. Further described herein is an electrochemical system comprising the composition-of-matter, wherein the first and third layers are each a lithium-based electrode, and batteries and supercapacitors comprising such an electrochemical system, as well as methods for preparing the composition-of-matter or the electrochemical system.

Abstract: Multi subunit protein modules are provided. Accordingly, there is provided a multi subunit protein module comprising at least three cell membrane polypeptides each comprising an amino acid sequence of an Fc receptor common gamma chain (FcRgamma), said amino acid sequence is capable of transmitting an activating signal; wherein at least one but not all of said at least three polypeptides comprises an extracellular binding domain capable of binding a target that is presented on a cell surface of a target cell of an immune cell, such that upon binding of said extracellular binding domain to said target said activating signal is transmitted in an immune cell expressing said multi subunit protein module. Also provided are cells expressing the multi subunit protein modules and uses thereof.

Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.

Abstract: The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.

Abstract: A lipidated secondary antibody is disclosed. Particles comprising same are also disclosed.

Abstract: Apparatus for medical treatment includes a laser source, which is configured to output a beam of laser radiation. An optical device is configured to direct the laser radiation to impinge on a limbal area of an eye with optical properties chosen so as to apply a desired treatment to a tissue structure associated with a cornea of the eye within the limbal area.

Abstract: A formulation includes an active agent, a thickening/solidifying agent, and an antioxidant. The active agent is 9-cis-?-carotene (9CBC) or a derivative thereof of the following formula: where R2 is H or methyl; X is optionally substituted with one or more methyl groups; n is an integer of 0-16; and the asterisk represents the point of attachment to the cyclohexene ring.

Abstract: A method of treating glioblastoma in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent that specifically decreases an amount and/or activity of P-selectin.