Patents Assigned to Ramot University Authority for Applied Research and Industrial Development Limited
  • Patent number: 6512014
    Abstract: A bioemulsifier composition useful for forming and stabilizing oil-in-water emulsions, comprising an esterase protein of 32.5 KD, found in association with emulsan in the bacteria Acinetobacter. The esterase, or parts of it, are isolated from cell extracts of various strains of Acinetobacter, or produced by any other means. The bioemulsifier composition is further comprised of a water-soluble polysaccharide polymer of any source. The present invention further discloses a method of forming and stabilizing oil-in-water emulsions, using the above-mentioned composition.
    Type: Grant
    Filed: December 13, 2000
    Date of Patent: January 28, 2003
    Assignee: Ramot University Authority for Applied Research and Industrial Development Limited
    Inventors: David Gutnick, Horacio R. Bach
  • Patent number: 6469061
    Abstract: A pharmaceutical composition useful for the treatment of cancer in mamnmals, comprising as the active ingredient a therapeutically effective amount of a jasmonate of the formula: wherein: n is 0,1, or 2; R1 is OH, alkoxy, O-glucosyl, or imino; R2 is OH, O, alkoxy or O-glucosyl; R3, R4 and R5 are H, OH, alkoxy or O-glucosyl; and/or wherein R1 and R2, or R1 and R4 together form a lactone; and further wherein the bonds between C3:C7, C4:C5, and C9:C10 may be double or single bonds; or a derivative of said formula; the derivative having at least one of the following: a lower acyl side chain at C3 (free acid, ester or conjugate); a keto or hydroxy (free hydroxy or ester) moiety at the C6 carbon; or an n-pentenyl or n-pentyl side chain at C7. These jasmonates are useful in treating a wide variety of malignancies.
    Type: Grant
    Filed: April 4, 2001
    Date of Patent: October 22, 2002
    Assignee: Ramot University Authority for Applied Research and Industrial Development Limited
    Inventors: Eliezer Flescher, Orit Fingrut