Patents Assigned to Ramot University Authority for Applied Research and
Industrial Development, Ltd.
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Patent number: 6933277Abstract: This invention relates to a method for reducing a condition associated with fetal alcohol syndrome in a subject who is exposed to alcohol in utero with an ADNF polypeptide. In particular, the present invention relates to a method of reducing a condition associated with fetal alcohol syndrome in a subject who is exposed to alcohol in utero with a combination of ADNF I and ADNF III polypeptides. The present invention further relates to a method for reducing neuronal cell death by contacting neuronal cells with a combination of ADNF I and ADNF III polypeptides. Still further, the present invention relates to a pharmaceutical composition comprising a combination of ADNF I and ADNF III polypeptides.Type: GrantFiled: March 12, 1999Date of Patent: August 23, 2005Assignees: The United States of America as represented by the Department of Health and Human Services, Ramot University Authority for Applied Research and Industrial Development, Ltd.Inventors: Douglas E. Brenneman, Catherine Y. Spong, Illana Gozes, Merav Bassan, Rachel Zamostiano
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Publication number: 20050119237Abstract: Disclosed is a method for inhibiting Ras-induced or mediated proliferation of cells associated with a non-malignant disease, disorder or pathological condition. The method entails administering to a patient a Ras antagonist in an amount effective to inhibit the proliferation. The invention is particularly applicable to diseases characterized by a proliferation of T-cells such as autoimmune disease, e.g., type 1 diabetes, lupus and multiple sclerosis, and pathological states such as graft rejection induced by the presentation of a foreign antigen such as a graft in response to a disease condition (e.g., kidney failure). Other non-malignant diseases characterized by proliferations of cells include cirrhosis of the liver and restenosis. Preferred Ras antagonists are S-trans-trans farnesylthiosalicylic acid (FTS) and structurally related compounds (or analogs) thereof.Type: ApplicationFiled: June 14, 2004Publication date: June 2, 2005Applicant: Ramot University Authority for Applied Research & Industrial Development Ltd.Inventors: Yoel Kloog, Joab Chapman, Dimitrius Karussis, Rafael Bruck, Shimon Reif, Michael Brownstein
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Patent number: 6861220Abstract: A method for screening molecule which have a synthetic lethal property when in combination with a gene of interest carrying a non-lethal mutation, said method comprising the steps of: transfecting a first reporter gene into mammalian cells having a genome comprising a gene of interest which carries a non-lethal mutation, or a genome which is null of said gene of interest; selecting clones stably expressing said fist reporter gene; introducing into said cells a survival plasmid comprising a functioning copy of said gene of interest, a second reporter gene, selectable marker, an origin of DNA replication and a nuclear antigen gene essential for replication of the plasmid within said cells, wherein said survivsal plasmid is autonomously replicating and spontaneously lost from said cells; growing said cells in the presence of a selection compound which selects for said selectable marker; selecting cell clones stably expressing said second reporter gene and said functioning copy of said gene of interest; removingType: GrantFiled: October 12, 2001Date of Patent: March 1, 2005Assignee: Ramot University Authority for Applied Research & Industrial Development LTDInventors: Dan Canaani, Arnold Simons, Naomi Dafni, Iris Dotan
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Patent number: 6858007Abstract: A method of characterizing an adnexal mass is disclosed, the method is effected by (a) obtaining a cross-sectional or projectional image of an examined adnex including the adnexal mass; (b) extracting boundaries of the adnexal mass; and (c) using a first algorithm for quantifying at least one morphological feature of the adnexal mass, thereby providing quantification of the at least one morphological feature.Type: GrantFiled: November 22, 1999Date of Patent: February 22, 2005Assignee: Ramot University Authority For Applied Research and Industrial Development Ltd.Inventors: Solange Akselrod, Ron Tepper, Yair Zimmer
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Publication number: 20040197798Abstract: A method of detecting cancer in a patient by detecting alteration of activity of the gene coding for human type protein phosphatase 2C (PP2C&agr; and PP2C&bgr;) and genetic polymorphisms thereof in a specimen isolated from the patient is disclosed. The invention further provides a method of treating cancer including the steps of first determining the type of cancer and cells expressing the cancer and then preparing a vector which will specifically target the cancer cells and can include regulatory elements to control the expressibility of PP2C&agr;. The vector is then administered to the patient. Alternatively an antisense vector can be prepared.Type: ApplicationFiled: October 3, 2003Publication date: October 7, 2004Applicant: Ramot University Authority for Applied Research and Industrial Development Ltd.Inventor: Sara Lavi
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Publication number: 20040193639Abstract: A method and system for managing data objects that are organized hierarchically according to type. The data objects are assigned to projects and subprojects independently of their type. At any one time, only one of the projects is “active”: by default, identifiers of data objects assigned to the active project are displayed for user access and newly created data objects are assigned to the active project. One embodiment of the invention uses a database to mirror the existing hierarchy. Another embodiment keeps all the data objects of each project in a single respective folder. Identifiers of the data objects of the active project are made collectively accessible at a graphical user interface, along with a project history.Type: ApplicationFiled: March 28, 2003Publication date: September 30, 2004Applicant: RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH AND INDUSTRIAL DEVELOPMENT LTD.Inventors: Ofer Bergman, Rafi Nachmias
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Publication number: 20040053313Abstract: The present invention relates generally to Activity Dependent Neurotrophic Factor III (ADNF III), also known as Activity Dependent Neuroprotective Protein (ADNP). More particularly, the present invention relates to nucleic acid sequences encoding ADNF III polypeptides; ADNF III polypeptides encoded by such nucleic acid sequences; antibodies to ADNF III polypeptides; and methods of using such ADNF III polypeptides for the treatment of neurological deficiencies and for the prevention of cell death associated with (1) gp120, the envelope protein from HIV; (2) N-methyl-D-aspartic acid (excito-toxicity); (3) tetrodotoxin (blockage of electrical activity); and (4) &bgr;-amyloid peptide, a substance related to neuronal degeneration in Alzheimer's disease.Type: ApplicationFiled: July 17, 2003Publication date: March 18, 2004Applicants: The Government of the USA as Represented by the Secretary of the Dept. of Health & Human Services, Ramot University Authority for Applied Research and Industrial Development, Ltd.Inventors: Illana Gozes, Douglas E. Brenneman, Merav Bassan, Rachel Zamostiano
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Patent number: 6686490Abstract: An active non-metallocene pre-catalyst featuring a diamine diphenolate complex and a corresponding method for catalytic polymerization, in general, and, tactic catalytic polymerization, in particular, of alpha-olefin monomers using the disclosed pre-catalyst.Type: GrantFiled: November 6, 2000Date of Patent: February 3, 2004Assignee: Ramot University Authority for Applied Research & Industrial Development Ltd.Inventors: Moshe Kol, Edit Y. Tshuva
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Publication number: 20040006043Abstract: A pharmaceutical composition which comprises a chemotherapeutically effective amount of one or more chemotherapeutic agent(s), being entrapped in a drug carrier, and a chemosensitizing effective amount of one or more chemosensitizing agent(s) and/or a chemoprotecting effective amount of one or more chemoprotecting agent(s) and methods of using same in cancer therapy.Type: ApplicationFiled: July 2, 2002Publication date: January 8, 2004Applicant: RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD.Inventors: Rimona Margalit, Dan Peer
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Publication number: 20030235658Abstract: Materials and methods are described for electroless deposition of cobalt phosphorus and cobalt tungsten phosphorus, employing tungsten trioxide or tungsten phosphoric acid as a source of tungsten.Type: ApplicationFiled: June 19, 2002Publication date: December 25, 2003Applicant: RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD.Inventors: Yosi Shacham-diamand, Yelena Sverdlov
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Patent number: 6653630Abstract: Scanning probe apparatus, including a tip-electrode which is coupled to be held at a substantially ground potential, a counter-electrode which is positioned in proximity to the tip-electrode, a voltage source, coupled to maintain the counter-electrode at a non-ground potential, and positioning-instrumentation, which is adapted to maintain the tip-electrode at a suitable position relative to a surface of a ferroelectric sample located in a space between the tip-electrode and the counter-electrode. The apparatus generates an electric field in the ferroelectric sample greater than a coercive field of the sample.Type: GrantFiled: November 30, 2001Date of Patent: November 25, 2003Assignee: Ramot - University Authority for Applied Research & Industrial Development Ltd.Inventors: Gil Rosenman, Yossi Rosenwaks, Ronen-Pavel Urenski
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Patent number: 6630124Abstract: The present invention relates to combination therapy using a pharmaceutical composition comprising a polypeptide which is an antagonist of the vasoactive intestinal polypeptide (VIP) and a chemotherapeutic agent. Methods of using the pharmaceutical composition are also disclosed.Type: GrantFiled: January 9, 2002Date of Patent: October 7, 2003Assignees: Ramot-University Authority for Applied Research and Industrial Development Ltd., Yeda Research and Development Co. Ltd., The United States of America as represented by the Department of Health and Human ServicesInventors: Illana Gozes, Mati Fridkin, Edgar Gelber, Terry W. Moody, Douglas C. Brenneman
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Patent number: 6617574Abstract: An apparatus and method for using &agr;-particle energy loss to measure the thickness and stoichiometry of films grown by molecular beam epitaxy and other methods. The apparatus for measuring the thickness of films grown on a substrate in a growth chamber, comprises a protective housing having an aperture opening into the growth chamber, a solid state detector disposed in the protective housing, a shutter for opening and closing the aperture, a shield disposed in the housing between the aperture and the solid state detector for shielding the detector, and a calibration source disposed between the shield and the detector for calibrating the measurements made by the detector. A second calibration source disposed between the shutter and the shield, for measuring deposition on the shield.Type: GrantFiled: November 19, 2001Date of Patent: September 9, 2003Assignees: TRIUMF, RAMOT, University Authority for Applied Research and Industrial Development Ltd., The University of British ColombiaInventors: Itzhak Kelson, Yuval Levy
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Patent number: 6613740Abstract: The present invention relates generally to Activity Dependent Neurotrophic Factor III (ADNF III), also known as Activity Dependent Neuroprotective Protein (ADNP). More particularly, the present invention relates to nucleic acid sequences encoding ADNF III polypeptides; ADNF III polypeptides encoded by such nucleic acid sequences; antibodies to ADNF III polypeptides; and methods of using such ADNF III polypeptides for the treatment of neurological deficiencies and for the prevention of cell death associated with (1) gp120, the envelope protein from HIV; (2) N-methyl-D-aspartic acid (excito-toxicity); (3) tetrodotoxin (blockage of electrical activity); and (4) &bgr;-amyloid peptide, a substance related to neuronal degeneration in Alzheimer's disease.Type: GrantFiled: November 6, 1998Date of Patent: September 2, 2003Assignees: Ramot University Authority for Applied Research and Industrial Development Ltd., The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Illana Gozes, Douglas E. Brenneman, Merav Bassan, Rachel Zamostiano
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Publication number: 20030148404Abstract: A method of identifying an existence, non-existence, type or state of a neurodegenerative disorder in an individual. The method is effected by (a) immunoreacting with a serum sample derived from the individual at least one peptide representing at least one epitope derived from an endogenous protein to which at least one antibody is produced in vivo at onset or during progression of the neurodegenerative disorder, the at least one peptide being selected such that the at least one antibody being capable of immunobinding with the at least one peptide; and (b) detecting a presence, absence or degree of the immunobinding to thereby identify the existence, non-existence, type or state of the neurodegenerative disorder.Type: ApplicationFiled: May 3, 2001Publication date: August 7, 2003Applicant: Ramot University Authority For Applied Research & Industrial Development Ltd.Inventor: Daniel M. Michaelson
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Patent number: 6597492Abstract: A method of fabricating an invertedly poled domain structure having alternating sections of opposite electric polarities, from a ferroelectric crystal wafer (1) having two opposite polar surfaces, comprises patterning at least one of the two polar surfaces of the wafer to comprise a plurality of alternating discrete regions, of which first regions are adapted for and second regions are protected from the direct application thereto of an electric contact; applying to both polar surfaces of the wafer electrically conducting electrodes (10 and 11) so that the first regions are in direct contact with the electrodes and the second regions are protected from such a contact; and applying to the electrodes an electrical field (20) of the intensity E. The electrical field is applied to the wafer at a working temperature by heater/cooler (15).Type: GrantFiled: April 28, 2000Date of Patent: July 22, 2003Assignees: The State of Israel Atomic Energy Commission Soreq Nuclear Research Center, Ramot University Authority for Applied Research & Industrial Development Ltd.Inventors: Gil Rosenman, Alexander Skliar, Moshe Oron, David Eger, Mordechai Katz
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Publication number: 20030129190Abstract: A method is provided for inhibiting or preventing adherence of cancer cells or immunocytes to their target cells or target tissues by reducing the level of activity of FX enzyme in the cells. The reduction may either be in the amount of the FX protein or in the enzymatic activity of the protein in the cells.Type: ApplicationFiled: January 15, 2003Publication date: July 10, 2003Applicant: Ramot University Authority for Applied Research & Industrial Development Ltd.Inventors: Isaac P. Witz, Rinat Eshel
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Patent number: 6569623Abstract: A screening method which applies the principle of synthetic lethality to a gene of interest in non-yeast eukaryotic cells. The method may be used to screen either a chemical library in order to identify a molecule having a gene-specific lethal property in the cells, or to screen a group of DNA molecules in order to identify among them one or more modulators of gene function which are synergistically lethal to the cells together with an incapacitated gene of interest. Also described are episomal survival plasmids and kits which may be used with the method.Type: GrantFiled: September 8, 1999Date of Patent: May 27, 2003Assignee: Ramot University Authority for Applied Research & Industrial Development Ltd.Inventors: Dan Canaani, Yoram Oron, Arnold Simons, Naomi Dafni, Iris Dotan
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Patent number: D476747Type: GrantFiled: November 5, 2001Date of Patent: July 1, 2003Assignees: Ramot University Authority for Applied Research and Industrial Development Ltd.Inventors: Naphtali Savion, Doron Lindner
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Patent number: D480482Type: GrantFiled: February 10, 2003Date of Patent: October 7, 2003Assignees: Ramot University Authority for Applied Research and Industrial Development Ltd.Inventors: Naphtali Savion, Doron Lindner