Patents Assigned to Ramot University Authority for Applied Research & Industrial Development
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Patent number: 6462086Abstract: Disclosed is a method for inhibiting Ras-induced or mediated proliferation of cells associated with a non-malignant disease, disorder or pathological condition. The method entails administering to a patient a Ras antagonist in an amount effective to inhibit the proliferation. The invention is particularly applicable to diseases characterized by a proliferation of T-cells such as autoimmune disease, e.g., type 1 diabetes, lupus and multiple sclerosis, and pathological states such as graft rejection induced by the presentation of a foreign antigen such as a graft in response to a disease condition (e.g., kidney failure). Other non-malignant diseases characterized by proliferations of cells include cirrhosis of the liver and restenosis. Preferred Ras antagonists are S-trans-trans farnesylthiosalicylic acid (FTS) and structurally related compounds (or analogs) thereof.Type: GrantFiled: June 19, 2000Date of Patent: October 8, 2002Assignee: Ramot University Authority for Applied Research and Industrial Development Ltd.Inventors: Yoel Kloog, Joab Chapman, Dimitrius Karussis, Rafael Bruck, Shimon Reif, Michael Brownstein
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Publication number: 20020136517Abstract: A waveguide for guiding electromagnetic radiation of a given range of wavelengths includes a transparent substrate made from non-polymer material, preferably glass, into which at least one elongated channel is etched. A polymer material with a higher refractive index than that of the substrate is deposited within, and extends along, the channel, so as to define a waveguide. The regions of the substrate adjacent to the ends of the channel are preferably treated, such as by ion-exchange, to form secondary waveguide portions, optically coupled to the polymer waveguide, for input and output optical coupling with the waveguide. Also disclosed is a production method for such waveguides.Type: ApplicationFiled: February 20, 2001Publication date: September 26, 2002Applicant: Ramot University Authority for Applied Research and Industrial Development Ltd.Inventors: Shlomo Ruschin, Tali Hurvits
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Publication number: 20020137186Abstract: Human herpes virus (HHV) 7 is capable of binding to the CD4 antigen and the HHV-7 or a binding protein derived therefrom is thus useful as a CD4-ligand for various therapeutic applications. HHV-6 or HHV-7 are lymphotropic and are thus useful as lymphotropic vectors for delivering DNA into lymphocytes.Type: ApplicationFiled: February 4, 2002Publication date: September 26, 2002Applicant: Ramot University Authority for Applied Research and Industrial Development Ltd.Inventor: Nitza Frenkel
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Patent number: 6447943Abstract: The present invention provides improved, low-cost fuel cells having reduced fuel crossover, reduced sensitivity to metal ion impurities and ability to operate under a broad range of temperatures. Additionally, new effective organic fuels are described for use in such fuel cells. The invention further provides improved methods for catalyst preparation and a new integrated flow field system for use in H2/O2 fuel cells. The fuel cell includes a proton conducting membrane having pore diameters which are essentially smaller than 30 nanometers.Type: GrantFiled: January 18, 2000Date of Patent: September 10, 2002Assignee: Ramot University Authority for Applied Research & Industrial Development Ltd.Inventors: Emanuel Peled, Tair Duvdevani, Avi Melman, Adi Aharon
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Publication number: 20020101648Abstract: A method and an electro-optical device are presented for affecting the propagation of input light impinging on the device. The electro-optical device is composed of at least one domain-patterned ferroelectric crystal structure with inverted domains, and an electrodes' arrangement on the surface of the at least one structure connected to a voltage source.Type: ApplicationFiled: December 11, 2000Publication date: August 1, 2002Applicant: Ramot University Authority for Applied Research & Industrial Development Ltd.Inventors: Ady Arie, Amir Burstein
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Patent number: 6420429Abstract: Novel brain targeted low molecular weight, hydrophobic antioxidants and use of antioxidants in treatment of central nervous system neurodegenerative disorders such as Parkinson's, Alzheimer's and Creutzfeldt-Jakob's diseases and in treatment of conditions of peripheral tissues, such as acute respiratory distress syndrome, amyotrophic lateral sclerosis, atheroscierotic cardiovascular disease and multiple organ dysfunction, in which oxidants are overproduced.Type: GrantFiled: June 1, 1999Date of Patent: July 16, 2002Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Ramot University Authority for Applied Research & Industrial Development Ltd., MOR-Research Applications Ltd.Inventors: Daphne Atlas, Eldad Melamed, Daniel Offen
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Patent number: 6418136Abstract: A system and a method for a dynamic probability access protocol for determining access to shared channels. Some networks have a common channel which is shared by many users. A key issue in such networks is the allocation of the shared channel among many competing users. The system and method of the present invention enable media access control in shared bandwidth networks. When the user wishes to send a message, the user transmits with a probability p, which depends on the load on the channel. The probability p is announced by the network, and transmitted to the users as a broadcast message. Under conditions of low load, the probability p approaches 1, while at high load p is relatively low. This media access control protocol guarantees high channel utilization at high load, as well as low delay at low load periods. The proposed method is applicable on wireless networks, such as cellular networks and satellite-based networks.Type: GrantFiled: November 18, 1998Date of Patent: July 9, 2002Assignee: Ramot University Authority for Applied Research and Industrial Development LTDInventors: Zohar Naor, Hanoch Levy
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Patent number: 6410460Abstract: A thermodynamically stable metallic contact for binary oxide-, nitride-, carbide or phosphide-semiconductors and a method of its preparation, the contact is formed in a high temperature reaction in vacuum of a metal bi-layer with the binary semiconductor substrate. With a proper choice of the two metallic layers, each metal forms a single phase with only one of binary semiconductor elements. The resulting phases form distinct layers in a thermodynamically stable sequence.Type: GrantFiled: May 15, 2000Date of Patent: June 25, 2002Assignees: Ramot University Authority for Applied Research and Industrial Development Ltd., Technion Research and Development Foundation Ltd.Inventors: Ilan Shalish, Yoram Shapira, Moshe Eizenberg
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Patent number: 6392588Abstract: A multifrequency phase-coded signal structure is presented for use in a system like a radar or sonar or detecting a remote target. The signal structure comprises at least one pulse signal in the form of a mutually complementary set of M sequences, each sequence being composed of M phase-modulated bits. Each two adjacent sequences are modulated on subcarriers separated by a frequency fs such that fs=1/tb, tb being a bit duration, and a the subcarriers are transmitted simultaneously.Type: GrantFiled: May 3, 2000Date of Patent: May 21, 2002Assignee: Ramot University Authority for Applied Research & Industrial Development Ltd.Inventor: Nadav Levanon
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Publication number: 20020050160Abstract: An apparatus and method for using &agr;-particle energy loss to measure the thickness and stoichiometry of films grown by molecular beam epitaxy and other methods. The apparatus for measuring the thickness of films grown on a substrate in a growth chamber, comprises a protective housing having an aperture opening into the growth chamber, a solid state detector disposed in the protective housing, a shutter for opening and closing the aperture, a shield disposed in the housing between the aperture and the solid state detector for shielding the detector, and a calibration source disposed between the shield and the detector for calibrating the measurements made by the detector. A second calibration source disposed between the shutter and the shield, for measuring deposition on the shield.Type: ApplicationFiled: November 19, 2001Publication date: May 2, 2002Applicant: TRIUMF, RAMOT, University Authority for Applied Research and Industrial Development Ltd.Inventors: Itzhak Kelson, Yuval Levy
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Patent number: 6373250Abstract: A method of slice selective multiple quantum magnetic resonance imaging of an object is disclosed. The method is effected by implementing the steps of (a) applying a radiofrequency pulse sequence selected so as to select a coherence of an order n to the object, wherein n is zero, a positive or a negative integer other than ±1; (b) applying magnetic gradient pulses, so as to select a slice of the object to be imaged arid to create an image; and (c) acquiring a radiofrequency signal resulting from the object, so as to generate a magnetic resonance slice image of the object. The method provides slice selective multiple quantum magnetic resonance images of yet unprecedented quality in terms of contrast. The method is particularly useful for imaging connective tissues.Type: GrantFiled: May 19, 2000Date of Patent: April 16, 2002Assignee: Ramot University Authority For Applied Research and Industrial Development Ltd.Inventors: Liat Tsoref, Uzi Eliav, Gil Navon
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Patent number: 6369106Abstract: A method of reducing oxidative stress in the brain of an organism having a blood brain barrier and suffering an ischemic brain injury, the method comprising the step of administering a compound to the organism, the compound having (a) a combination of molecular weight and membrane miscibility properties for permitting the compound to cross the blood brain barrier of the organism; (b) a readily oxidizable chemical group for exerting antioxidation properties; and (c) a chemical make-up for permitting the compound or its intracellular derivative to accumulate within the cytoplasm of cells.Type: GrantFiled: December 27, 1999Date of Patent: April 9, 2002Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Mor-Research Applications Ltd., Ramot University Authority for Applied Research & Industrial Development Ltd.Inventors: Daphne Atlas, Eldad Melamed, Daniel Offen
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Patent number: 6344893Abstract: A super-resolving imaging apparatus employs diffractive optical elements placed on the imaging lens. This element, and the use of a modified Scheimpflug arrangement allow the conversion of degrees of freedom in one axis of a field of view to a larger degree of freedom in another axis in order to obtain a high resolution image with a wide depth of focus and large field of view. Replicas created by the diffractive elements are mutually shifted by subpixel amounts, and are combined using a Gabor transform, which is facilitated by a spatial mask placed over the detector array. The apparatus is suitable for performing distance estimation on an object within the field of view.Type: GrantFiled: June 19, 2000Date of Patent: February 5, 2002Assignee: Ramot University Authority for Applied Research and Industrial Development Ltd.Inventors: David Mendlovic, Zeev Zalevsky, Naim Konforti, Emanuel Marom, Gal Shabtay, Uriel Levy, Sharon Karako
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Patent number: 6342265Abstract: An apparatus and method for using &agr;-particle energy loss to measure the thickness and stoichiometry of films grown by molecular beam epitaxy and other methods. The apparatus for measuring the thickness of films grown on a substrate in a growth chamber, comprises a protective housing having an aperture opening into the growth chamber, a solid state detector disposed in the protective housing, a shutter for opening and closing the aperture, a shield disposed in the housing between the aperture and the solid state detector for shielding the detector, and a calibration source disposed between the shield and the detector for calibrating the measurements made by the detector. A second calibration source disposed between the shutter and the shield, for measuring deposition on the shield.Type: GrantFiled: August 20, 1997Date of Patent: January 29, 2002Assignees: Triumf, Ramot-University Authority for Applied Research & Industrial Development Ltd., The University of British ColumbiaInventors: Itzhak Kelson, Yuval Levy
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Publication number: 20020009805Abstract: The invention concerns a scaffold which is used as a growth supportive base for various cells and tissue explants from three-dimensional tissue comprising naturally derived connective or skeletal tissue into attached flakes having a very high porosity. Alternatively the scaffold is composed of fused epiphyses.Type: ApplicationFiled: April 4, 2001Publication date: January 24, 2002Applicant: RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD.Inventors: Zvi Nevo, Dror Robinson
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Patent number: 6337159Abstract: A non-aqueous electrochemical cell comprising a cathode, non-aprotic or polymeric electrolyte and an anode of carbon-based bonded particles coated with a thin (less than 1 micron thick) solid electrolyte interphase which is a M conductor and electronic insulator consisting of alkali metal or alkaline earth salts, oxides or sulfides, said cell being assembled in the non-charged state.Type: GrantFiled: February 4, 1999Date of Patent: January 8, 2002Assignee: Ramot University Authority for Applied Research & Industrial Development Ltd.Inventors: Emanuel Peled, Avi Melman, Chen Menachem, Yitzhak Lavi, Dany Bar-Tov
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Patent number: 6333423Abstract: Disclosed are compounds of the following formulae, and their use in the polymerization of olefins: wherein M is preferably titanium, zirconium or hafnium, R1-R8 are univalent radicals, X1 and X2 are univalent ligands, X3 is a divalent ligand, and (RnY—T) is an optional donor or non-donor group.Type: GrantFiled: September 10, 1999Date of Patent: December 25, 2001Assignees: Ramot University Authority for Applied Research and Industrial Development Ltd., Bar-Ilan UniversityInventors: Moshe Kol, Edit Tshuva, Zeev Goldschmidt
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Patent number: 6329202Abstract: Binding of two members of a binding couple reveals epitopes which are revealed only after binding and the monoclonal antibody secreted from the hybridoma cell line CG-10 directed against these epitopes bind to the bound couple at a significantly higher affinity than their binding affinity to either of the two members themselves when not bound to one another.Type: GrantFiled: August 24, 2000Date of Patent: December 11, 2001Assignee: Ramot University Authority for Applied Research and Industrial Development Ltd.Inventor: Jonathan M. Gershoni
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Patent number: 6303125Abstract: A non-food anti-microbial-adhesion and aggregation composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of the Vaccinium plant genus. In an embodiment the anti-aggregation and adhesion fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight ≧14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; a nuclear magnetic resonance (NMR) line spectrum as set forth in FIGS. 2A and 2B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against P fimbriated bacteria, oral bacteria and Helicobacter pylori.Type: GrantFiled: September 24, 1998Date of Patent: October 16, 2001Assignee: RAMOT-University Authority for Applied Research and Industrial Development Ltd.Inventors: Itzhak Ofek, Ervin Weiss, Yoel Kashman, Janina Goldhar, Nathan Sharon
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Patent number: 6280390Abstract: A system for non-invasively monitoring at least one hemodynamic vascular parameter of an individual is disclosed. The system comprises (a) at least two infrared detectors being positionable in a spaced apart configuration against a region of a skin of the individual above at least one blood vessel, each of said at least two infrared detectors being for individually collecting infrared spectral data from said region of the skin, said infrared spectral data corresponding to a volume of blood present within said at least one blood vessel; and (b) a processing unit being in communication with said at least two infrared detectors, said processing unit being for independently processing said infrared spectral data collected by each of said at least two infrared detectors so as to yield information pertaining to the at least one hemodynamic vascular parameter of the individual.Type: GrantFiled: December 29, 1999Date of Patent: August 28, 2001Assignee: Ramot University Authority for Applied Research and Industrial Development Ltd.Inventors: Solange Akselrod, Amir Schechter