Patents Assigned to Ranbaxy Laboratories Limited
  • Substituted Pyrrole Derivatives and Their Use as HMG-CO Inhibitors
    Publication number: 20110190369
    Abstract: The present invention relates to substituted pyrrole derivatives, which can be used as 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Compounds disclosed herein can function as cholesterol lowering agents and can be used for the treatment of cholesterol-related diseases and related symptoms. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and methods of treating cholesterol-related diseases and related symptoms.
    Type: Application
    Filed: April 11, 2011
    Publication date: August 4, 2011
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Mohammad SALMAN, Jitendra SATTIGERI, Yatendra KUMAR, Ram Chander ARYAN, Vikram Krishna RAMANATHAN, Anita CHUGH
  • PROCESS FOR THE PREPARATION OF 3,4-EPOXY-2-AMINO-1-SUBSTITUTED BUTANE DERIVATIVES AND INTERMEDIATE COMPOUNDS THEREOF
    Publication number: 20110178305
    Abstract: The present invention relates to a process for the preparation of threo-3,4-epoxy-2-amino-1-substituted butane derivatives represented by general Formula I which comprises reacting compound of Formula III or salt thereof with an active ester of acid of Formula IV and treating the product thereof with base. The carbon atom bonded to the radical R3 in Formula I and IV is in the (R)-, (S)- or (R,S)-configuration. The compounds of Formula I and III, particularly in their (2S,3R) configuration are useful intermediates for the preparation of atazanavir bisulfate.
    Type: Application
    Filed: May 5, 2009
    Publication date: July 21, 2011
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Rakesh Singh, Prasad Yeragorla, Mahavir Singh Khanna, Mohan Prasad
  • PROCESS FOR PREPARING A CARBAPENEM ANTIBIOTIC COMPOSITION
    Publication number: 20110172201
    Abstract: The present invention relates to a process for preparing a carbapenem antibiotic composition. The present invention further relates to a carbapenem antibiotic composition substantially free of degradation impurities. The present invention further relates to a polymorphic form of ertapenem mono sodium designated as Form D and its preparation.
    Type: Application
    Filed: June 12, 2009
    Publication date: July 14, 2011
    Applicant: Ranbaxy Laboratories Limited
    Inventors: Vinod George, Bhupendra Vashishta, Mohan Prasad, Naresh Kumar, Vinod Kumar Arora
  • Process for the preparation of faropenem
    Patent number: 7977475
    Abstract: The present invention is related to processes for the preparation of faropenem, which comprises treating the compound of Formula II, with an alkali metal salt of a substituted or unsubstituted C5-10 carboxylic acid and a catalytic amount of a palladium complex in the presence of an organic solvent, followed by the treatment of the reaction mixture of with water and a water miscible solvent, and isolating a hydrate of an alkali metal salt of faropenem from the reaction mass, wherein water is not removed from the reaction mixture in water treatment or isolation steps.
    Type: Grant
    Filed: October 5, 2006
    Date of Patent: July 12, 2011
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Neela Praveen Kumar, Mohan Prasad
  • BENZOTHIAZOLES AND AZA-ANALOGUES THEREOF USE AS ANTIBACTERIAL AGENTS
    Publication number: 20110166088
    Abstract: The present invention provides Gyrase B and/or Topoisomerase IV par E inhibitors, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed by gram positive, gram negative and anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Pseudomonas spp., Acenetobacter spp., Moraxalla spp., Chlamydia spp., Mycoplasma spp., Legionella spp., Ktycobacterium spp., Helicobacter, Clostridium spp., Bacteroides spp., Corynebacterium, Bacillus spp., Enterobactericeae,’ (E. coli, Klebsiella spp., Proteus spp., etc.) or any combination thereof. Also provided, are processes for preparing compounds disclosed herein, pharmaceutical compositions containing compounds disclosed herein, and methods of treating bacterial infections.
    Type: Application
    Filed: June 25, 2009
    Publication date: July 7, 2011
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Jitendra A. Sattigeri, Naresh Kumar, Ajay Yadav, Lalima Sharma, Ian A. Cliffe, Shibu B. Varughese, Shaikh Rizwan Shabbir, V. Samuel Raj, Dilip J. Upadhyay, Pradip K. Bhatnager
  • Pharmaceutical compositions
    Patent number: 7956198
    Abstract: This invention relates to a combination product or medicament comprising at least one novel substituted pyrrole derivative and one or more dyslipidemic agents, antiobesity agents, antihyperglycaemic agents, anti-inflammatory agents or mixture thereof.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: June 7, 2011
    Assignee: Ranbaxy Laboratories, Limited
    Inventors: Jitendra A. Sattigeri, Vinay S. Bansal
  • PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS
    Publication number: 20110130403
    Abstract: The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors.
    Type: Application
    Filed: March 13, 2008
    Publication date: June 2, 2011
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Sonali Rudra, Nidhi Gupta, Lalit Kumar Baregama, Ritu Agarwal, Mandadapu Raghuramaiah, Vinayak Vasantrao Khairnar, Venkata P. Palle, Sarala Balachandran, Abhijit Ray, Sunada G. Dastidar, Lalitha Vijaykrishnan
  • PROCESS FOR THE PREPARATION OF DISPIRO 1,2,4-TRIOXOLANE ANTIMALARIALS (OZ277)
    Publication number: 20110124886
    Abstract: This invention relates to an improved process for the preparation of a compound of Formula (I), salts of the free base cis-adamantane-2-spiro-3?-8?-[[[(2?-amino-2?-methyl propyl)amino]carbonyl]methyl]-1?,2?,4?-trioxaspiro[4.5]decane wherein X can be an anion.
    Type: Application
    Filed: May 24, 2007
    Publication date: May 26, 2011
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Gyan Chand Yadav, Harish N. Dorwal, Srinivas Valavala, Vinod Kamar Sharma
  • Processes for the preparation of intermediates of valsartan
    Patent number: 7943794
    Abstract: The present invention relates to processes for the preparation of intermediates of valsartan.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: May 17, 2011
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Ira Saxena, Asok Nath, Mohan Prasad
  • PROCESS FOR THE PREPARATION OF STERILE DORIPENEM
    Publication number: 20110082293
    Abstract: The present invention relates to a process for the preparation of sterile doripenem.
    Type: Application
    Filed: March 23, 2009
    Publication date: April 7, 2011
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Vinod George, Hashim Nizar Poovanathil Nagoor Meeran, Neera Tiwari, Mohan Prasad
  • Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
    Patent number: 7915286
    Abstract: The present invention relates to phosphodiesterase (PDE) type IV selective inhibitors. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type IV selective inhibitors are provided. Prepared compounds correspond to structure XIV Formula (XIV).
    Type: Grant
    Filed: September 11, 2006
    Date of Patent: March 29, 2011
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Venkata P. Palle, Sarala Balachandran, Nidhi Gupta, Vinayak Vasantrao Khairnar, Mandadapu Raghuramaiah, Abhijit Ray, Sunanda Ghose Dastidar
  • Processes for the preparation of substituted sulfoxides
    Patent number: 7915422
    Abstract: The present invention relates to a process for enantioselective synthesis of substituted pyridinylmethyl sulfinyl-benzimidazole of compound of Formula (I). The process includes enantioselective catalytic oxidation of a substituted pyridinylmethyl prochiral sulfide derivative of compound of Formula (II) with an oxidizing agent in the presence of a chiral transition metal complex and a base in the absence of an organic solvent.
    Type: Grant
    Filed: October 4, 2005
    Date of Patent: March 29, 2011
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Neela Praveen Kumar, Mahavir Singh Khanna, Mohan Prasad, Yatendra Kumar
  • PROCESS FOR THE PREPARATION OF EFAVIRENZ
    Publication number: 20110071287
    Abstract: The present invention relates to a process for the preparation of Efavirenz (Formula I), wherein triphosgene is used as a cyclizing agent.
    Type: Application
    Filed: May 1, 2009
    Publication date: March 24, 2011
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Mukesh Kumar Madhra, Pankaj Kumar Singh, Mukesh Sharma, Chandra Has Khanduri
  • MODIFIED RELEASE LAMOTRIGINE TABLETS
    Publication number: 20110052686
    Abstract: The present invention relates to uncoated modified-release tablets of lamotrigine and the process for preparation thereof, wherein the tablets comprise a portion of lamotrigine in an admixture with a pH-dependent polymer.
    Type: Application
    Filed: September 2, 2010
    Publication date: March 3, 2011
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Murali Krishna Bhavarisetti, Rajan K. Verma, Romi Barat Singh
  • PROCESS FOR THE PREPARATION OF PURE PRULIFLOXACIN
    Publication number: 20110034690
    Abstract: The present invention relates to a process for the preparation of prulifloxacin. The present invention further relates to prulifloxacin having purity of about 99% or above.
    Type: Application
    Filed: March 14, 2008
    Publication date: February 10, 2011
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Tarun Kant Sharma, Raghuram Morampudi, Shanmugam Srinivasan
  • SOLID DOSAGE FORMS OF HIV PROTEASE INHIBITORS
    Publication number: 20110034489
    Abstract: The present invention relates to a solid dosage form comprising a solid dispersion composition of at least one HIV protease inhibitor and water soluble polymer having a glass transition temperature (Tg) of at least about 50° C. in an amount of less than 50% by weight of the dosage form. It also relates to a process of preparation of such solid dosage forms.
    Type: Application
    Filed: August 2, 2010
    Publication date: February 10, 2011
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Ravindra TIWARI, Kannayiram K. JANAKIRAMAN, Ravindra AGARWAL, Rajeev Singh RAGHUVANSHI
  • MULTILAYERED MODIFIED RELEASE FORMULATION COMPRISING AMOXICILLIN AND CLAVULANATE
    Publication number: 20110020408
    Abstract: The present invention relates to multilayered modified release formulation comprising amoxicillin and clavulanate, process of preparation thereof and method of treating bacterial infection using these formulations. The multilayered modified release formulation comprises: an immediate release layer comprising amoxicillin and clavulanate; and a slow release layer comprising amoxicillin and one or more release retarding agents; and one or more non-release controlling inert barrier layers placed in between the immediate release layer and the slow release layer and comprising one or more pharmaceutically acceptable excipients.
    Type: Application
    Filed: May 16, 2008
    Publication date: January 27, 2011
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Kalaiselvan Ramaraju, Rajan Kumar Verma, Ashok Rampal
  • Barium salt of benzimidazole derivative
    Patent number: 7872140
    Abstract: The invention relates to crystalline barium salt of (S)-omeprazole, which is (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole. The invention also relates to processes for preparing crystalline barium salt of (S)-omeprazole and pharmaceutical compositions that include the crystalline barium salt of (S)-omeprazole so prepared.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: January 18, 2011
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Yatendra Kumar, Mahavir Singh Khanna, Mohan Prasad
  • CRYSTALLINE FORM I OF LAMIVUDINE AND ITS PREPARATION
    Publication number: 20100324290
    Abstract: The present invention relates to a stable crystalline Form I of lamivudine. The present invention further relates to a process for the preparation of the stable crystalline Form (I) of the stable crystalline Form (I) of lamivudine.
    Type: Application
    Filed: April 30, 2008
    Publication date: December 23, 2010
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Sayeed Mukhtar, Vishwesh Pravinchandra Pandya, Shivanand Shrishailacpa Kokatnur
  • PROCESS FOR THE PREPARATION OF SUBSTITUTED 1,3-OXATHIOLANES
    Publication number: 20100311970
    Abstract: The present invention relates to a process for the preparation of substituted 1,3-oxathiolanes. The present invention specifically relates to a process for the preparation of lamivudine.
    Type: Application
    Filed: April 30, 2008
    Publication date: December 9, 2010
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Neera Tewari, Dinesh Shashidharan Nair, Hashim Nizar Poovanathil Nagoor Meeran, Mohan Prasad