Abstract: System and methods for lipid removal from the body, and more particularly, system and methods for treating obesity by lipid removal. In an embodiment, the methods of the present invention include the steps of delivering a hormone activator to the body to initiate the conversion of triglycerides to free fatty acids, and removing the free fatty acids from the body. The invention also includes a system for removing lipids from the body comprising a delivery means for delivering a hormone activator to an adipocyte and a removal means for removing fatty acids from the body.