Patents Assigned to Randox Laboratories Ltd.
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Publication number: 20080153172Abstract: A method of diagnosis of chronic stress in a patient, comprising: (a) determining the level of each of one or more analytes in the patient, wherein the one or more analytes are selected from VEGF, IL-8, MCP1, EGF and TSH; and (b) establishing the significance of the or each level.Type: ApplicationFiled: April 14, 2005Publication date: June 26, 2008Applicant: RANDOX LABORATORIES LTD.Inventors: Marie Asberg, Ake Nygren, Rolf Ekman
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Publication number: 20070281895Abstract: A diagnostic method is disclosed which can be used to predict the risk of cancer in particular breast cancer. The method comprises: (i) isolating a biological sample from a patient; and (ii) detecting the presence or expression of the gene comprised within the sequence identified herein as SEQ ID No. (1), wherein the presence or expression of the gene indicates the presence of or the risk of cancer.Type: ApplicationFiled: November 9, 2004Publication date: December 6, 2007Applicant: Randox Laboratories Ltd.Inventors: Martin Crockard, Janice Bailie, John Lamont, Stephen Fitzgerald
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Patent number: 7270788Abstract: An assay device processing instrument comprises a plurality of processing modules. A transport system transports an assay device to each processing module, the transport system being adapted to transfer the assay device from the transport system to the module to enable the transport system to transport another assay device while the first is processed by the processing module. A control system controls operation of the transport system such that each assay device is transferred between the modules in a predetermined sequence, and such that a number of assay devices can be processed in different modules simultaneously.Type: GrantFiled: August 20, 2003Date of Patent: September 18, 2007Assignee: Randox Laboratories Ltd.Inventors: James Rudolph Meyer, Ahti Kalevi Kansanaho, Stephen Peter Fitzgerald, Ivan Robert McConnell, John Victor Lamont, Bailin Cao
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Patent number: 7241630Abstract: A method of determining the number of magnetic particles within a sample using a tuned circuit having a capacitor and a coil. The method comprises: a. determining the difference in the resonant frequency of the tuned circuit when the sample is exposed to a magnetic field generated by the coil and when the sample is not exposed to the magnetic field generated by the coil; and b. using the difference in the resonant frequency to determine the number of magnetic particles within the sample.Type: GrantFiled: March 26, 2001Date of Patent: July 10, 2007Assignee: Randox Laboratories, Ltd.Inventors: Peter Hawkins, Richard William Luxton
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Patent number: 7109310Abstract: The invention provides an immunogen comprising a hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the aforementioned hapten coupled to a labelling agent, as well as, antibodies raised against the aforementioned immunogen and capable of binding with at least one structural epitope of metabolites of fentanyl and of metabolites of fentanyl analogs.Type: GrantFiled: November 15, 2002Date of Patent: September 19, 2006Assignee: Randox Laboratories, Ltd.Inventors: Robert Ivan McConnell, Elouard Benchikh, Stephen Peter Fitzgerald, John Victor Lamont
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Patent number: 7026134Abstract: Novel haptens, which can be conjugated to form immunogens, are of formula I, II or III wherein R is a divalent alkyl, cycloalkyl or aryl group having 1 to 10 carbon atoms, and X is a functional group.Type: GrantFiled: December 20, 2002Date of Patent: April 11, 2006Assignee: Randox Laboratories Ltd.Inventors: John Victor Lamont, Robert Ivan McConnell, Stephen Peter Fitzgerald, El Ouard Benchikh, Andrew Philip Lowry
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Patent number: 6902897Abstract: A biochip deposition system and method. The system comprises a deposit mechanism for depositing organic material in spots on a substrate; and a viewing system for detecting the spots on the substrate during a deposit operation and before the spots have dried, for determining if the spots have been correctly deposited, and if not, for generating a suitable output signal. The viewing system includes an illumination device for illuminating deposited spots at a relatively low angle relative to the substrate.Type: GrantFiled: July 5, 2002Date of Patent: June 7, 2005Assignee: Randox Laboratories, Ltd.Inventors: Mark Tweedie, John Victor Lamont, Robert Ivan McConnell, Stephen Peter Fitzgerald
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Patent number: 6897026Abstract: A method for imaging molecules contained in an array of discrete reaction sites on the surface of a solid support comprises: (i) imaging the array and detecting a first molecule located on the solid support at a known position with respect to the array; (ii) by reference to the first molecule, aligning inspection windows in registration with the discrete reaction sites; and (iii) determining the amount of detectable signal in each window. The method is used to locate the reaction sites accurately on the array, and to correct for any misalignments.Type: GrantFiled: January 17, 2002Date of Patent: May 24, 2005Assignee: Randox Laboratories Ltd.Inventors: John Victor Lamont, Robert Ivan McConnell, Stephen Peter Fitzgerald
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Publication number: 20040191890Abstract: An assay device processing instrument comprises a plurality of processing modules. A transport system transports an assay device to each processing module, the transport system being adapted to transfer the assay device from the transport system to the module to enable the transport system to transport another assay device while the first is processed by the processing module. A control system controls operation of the transport system such that each assay device is transferred between the modules in a predetermined sequence, and such that a number of assay devices can be processed in different modules simultaneously.Type: ApplicationFiled: August 20, 2003Publication date: September 30, 2004Applicant: RANDOX LABORATORIES LTDInventors: James Rudolf Meyer, Ahti Kalevi Kansanaho, Stephen Peter Fitzgerald, Robert Ivan McConnell, John Victor Lamont, Bailin Cao
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Patent number: 6767715Abstract: A compound of the formula wherein X is Cl or CH3, or a salt thereof, is useful as a spin trap in various assays.Type: GrantFiled: December 11, 2001Date of Patent: July 27, 2004Assignee: Randox Laboratories Ltd.Inventors: Lynne Hamilton, Paul Graham Winyard
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Patent number: 6649128Abstract: An assay device processing instrument comprises a plurality of processing modules. A transport system transports an assay device to each processing module, the transport system being adapted to transfer the assay device from the transport system to the module to enable the transport system to transport another assay device while the first is processed by the processing module. A control system controls operation of the transport system such that each assay device is transferred between the modules in a predetermined sequence, and such that a number of assay devices can be processed in different modules simultaneously.Type: GrantFiled: September 17, 1999Date of Patent: November 18, 2003Assignee: Randox Laboratories LTDInventors: James Rudolf Meyer, Ahti Kalevi Kansanaho, Stephen Peter Fitzgerald, Robert Ivan McConnell, John Victor Lamont, Bailin Cao
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Publication number: 20030157565Abstract: Novel haptens, which can be conjugated to form immunogens, are of formula I, II or III 1Type: ApplicationFiled: December 20, 2002Publication date: August 21, 2003Applicant: RANDOX LABORATORIES LTD.Inventors: John Victor Lamont, Robert Ivan McConnell, Stephen Peter Fitzgerald, El Ouard Benchikh, Andrew Philip Lowry
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Patent number: 6579707Abstract: A method for stabilizing an enzyme during freezing, wherein the enzyme is in a zwitterionic buffer solution. The zwitterionic buffer is able to maintain the activity of the enzyme during freezing and thawing.Type: GrantFiled: September 12, 2001Date of Patent: June 17, 2003Assignee: Randox Laboratories Ltd.Inventors: Stephen Peter Fitzgerald, John Campbell, John Victor Lamont, Marlene King
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Publication number: 20030109051Abstract: A spin-trapping assay for nitric oxide, in a biological system such as whole blood, uses as the spin trap a lipid-soluble nitrobenzene compound such as 2,6-dimethylnitrosobenzene.Type: ApplicationFiled: October 15, 2002Publication date: June 12, 2003Applicant: RANDOX LABORATORIES LTDInventors: Stephen Peter Fitzgerald, Lynne Hamilton, Paul Graham Winyard
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Publication number: 20030044833Abstract: Multi-analyte microarrays are produced by first attaching to the surface of a solid support, a silane with an electrophilic terminal group, contacting the terminal group with a polyamine, and activating the polyamine with an electrophilic, bifunctional linker.Type: ApplicationFiled: September 4, 2002Publication date: March 6, 2003Applicant: Randox Laboratories Ltd.Inventors: Elouard Benchikh, Robert Ivan McConnell, John Victor Lamont, Stephen Peter Fitzgerald
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Publication number: 20030008385Abstract: A biochip deposition system and method. The system comprises a deposit mechanism for depositing organic material in spots on a substrate; and a viewing system for detecting the spots on the substrate during a deposit operation and before the spots have dried, for determining if the spots have been correctly deposited, and if not, for generating a suitable output signal. The viewing system includes an illumination device for illuminating deposited spots at a relatively low angle relative to the substrate.Type: ApplicationFiled: July 5, 2002Publication date: January 9, 2003Applicant: RANDOX LABORATORIES LTDInventors: Mark Tweedie, John Victor Lamont, Robert Ivan McConnell, Stephen Peter Fitzgerald
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Patent number: 6498010Abstract: A solid state device for performing multi-analyte assays, comprises a substrate and a multiplicity of discrete reaction sites each bearing a ligand covalently bonded to the substrate, wherein the surface of the substrate between the reaction sites is inert with respect to analyte. Such a device may be obtained by a process of activating the surface of the substrate, and applying an array of ligands on to discrete areas on the surface.Type: GrantFiled: October 7, 1999Date of Patent: December 24, 2002Assignee: Randox Laboratories, LTDInventors: Stephen Peter Fitzgerald, John Victor Lamont, Robert Ivan McConnell, El Ouard Benchikh
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Publication number: 20020146847Abstract: A method for imaging molecules contained in an array of discrete reaction sites on the surface of a solid support comprises:Type: ApplicationFiled: January 17, 2002Publication date: October 10, 2002Applicant: RANDOX LABORATORIES LTD.Inventors: John Victor Lamont, Robert Ivan McConnell, Stephen Peter Fitzgerald
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Publication number: 20020086338Abstract: A compound of the formula 1Type: ApplicationFiled: December 11, 2001Publication date: July 4, 2002Applicant: RANDOX LABORATORIES, LTD.Inventors: Lynne Hamilton, Paul Graham Winyard
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Publication number: 20020086337Abstract: An assay for an analyte in a sample, wherein the sample is contacted with an array of ligands including a ligand specific for the analyte, additionally comprises including a scavenger material that binds the analyte and thereby reduces its available concentration.Type: ApplicationFiled: September 12, 2001Publication date: July 4, 2002Applicant: RANDOX LABORATORIES LTD.Inventors: Stephen Peter Fitzgerald, John Victor Lamont, Robert Ivan McConnell