Patents Assigned to Rapid Micro Biosystems, Inc.
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Patent number: 11788046Abstract: The invention provides a device for growing cells—referred to as a cassette. The cell culturing device includes a housing that contains a lid having an optically clear window; a fluid distribution channel; a sample injection port fluidically connected to the fluid distribution channel; a base housing a porous media pad; and a media injection port fluidically connected to the media pad. The lid mates to the base to form a sterile seal; the fluid distribution channel is disposed over the media pad, which is viewable through the optical window; and sample fluid introduced into the fluid distribution channel is distributed evenly to the media pad, e.g., via a plurality of channels. The invention also provides kits that include cassettes of the invention and a tube set.Type: GrantFiled: October 9, 2020Date of Patent: October 17, 2023Assignee: Rapid Micro Biosystems, Inc.Inventors: Robert C. Aviles, Devin T. Michaud, Douglas J. Browne
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Patent number: 11732237Abstract: The present invention features general-purpose microbiological growth media capable of supporting growth of microorganisms on membranes. The media contain casein digest, soybean digest, animal tissue digest, yeast extract, dextrose, a phosphate buffer, hemin, and L-cystine. The invention features an all-purpose microbiological growth media that can support the growth of anaerobes, molds, injured spores, and general aerobic bacteria to a greater extent than other media.Type: GrantFiled: October 5, 2020Date of Patent: August 22, 2023Assignee: Rapid Micro Biosystems, Inc.Inventors: Kate Shara, Julie Schwedock, Sommer Vogel
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Patent number: 11643677Abstract: The invention features devices and kits for capturing and culturing microorganisms (e.g., bacteria, fungi, or protists) and methods of using the devices and kits to detect microorganisms in environmental and other samples. The device includes a nutrient media having a flat growth area on which microorganisms can grow. Samples are collected by contacting the device with any environmental sample, e.g., rolling device on a work surface or exposing device to air, or by filtering a sample through a membrane. Microorganisms deposited on the membrane derive nutrients from the underlying media and grow into colonies that can then be detected using methods known in the art. The detected colonies can be imaged digitally or with film.Type: GrantFiled: September 9, 2019Date of Patent: May 9, 2023Assignee: RAPID MICRO BIOSYSTEMS, INC.Inventors: Douglas J. Browne, Sarkis Karakozian, Xiaowei Chen
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Patent number: 11499176Abstract: The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial enumeration tests based on the invention address an important problem in clinical and industrial microbiology—the long time needed for detection in traditional tests—while retaining key advantages of the traditional methods based on microbial culture. Embodiments of the invention include non-destructive aseptic methods for detecting cellular microcolonies without labeling reagents. These methods allow for the generation of pure cultures which can be used for microbial identification and determination of antimicrobial resistance.Type: GrantFiled: March 1, 2016Date of Patent: November 15, 2022Assignee: RAPID MICRO BIOSYSTEMS, INC.Inventor: Don Straus
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Patent number: 10801004Abstract: The invention provides a device for growing cells—referred to as a cassette. The cell culturing device includes a housing that contains a lid having an optically clear window; a fluid distribution channel; a sample injection port fluidically connected to the fluid distribution channel; a base housing a porous media pad; and a media injection port fluidically connected to the media pad. The lid mates to the base to form a sterile seal; the fluid distribution channel is disposed over the media pad, which is viewable through the optical window; and sample fluid introduced into the fluid distribution channel is distributed evenly to the media pad, e.g., via a plurality of channels. The invention also provides kits that include cassettes of the invention and a tube set.Type: GrantFiled: August 28, 2017Date of Patent: October 13, 2020Assignee: Rapid Micro Biosystems, Inc.Inventors: Robert C. Aviles, Devin T. Michaud, Douglas J. Browne
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Patent number: 10793823Abstract: The present invention features general-purpose microbiological growth media capable of supporting growth of microorganisms on membranes. The media contain casein digest, soybean digest, animal tissue digest, yeast extract, dextrose, a phosphate buffer, hemin, and L-cystine. The invention features an all-purpose microbiological growth media that can support the growth of anaerobes, molds, injured spores, and general aerobic bacteria to a greater extent than other media.Type: GrantFiled: April 24, 2015Date of Patent: October 6, 2020Assignee: Rapid Micro Biosystems, Inc.Inventors: Kate Shara, Julie Schwedock, Sommer Vogel
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Patent number: 10407707Abstract: The invention features devices and kits for capturing and culturing microorganisms (e.g., bacteria, fungi, or protists) and methods of using the devices and kits to detect microorganisms in environmental and other samples. The device includes a nutrient media having a flat growth area on which microorganisms can grow. Samples are collected by contacting the device with any environmental sample, e.g., rolling device on a work surface or exposing device to air, or by filtering a sample through a membrane. Microorganisms deposited on the membrane derive nutrients from the underlying media and grow into colonies that can then be detected using methods known in the art. The detected colonies can be imaged digitally or with film.Type: GrantFiled: April 16, 2013Date of Patent: September 10, 2019Assignee: Rapid Micro Biosystems, Inc.Inventors: Douglas J. Browne, Sarkis Karakozian, Xiaowei Chen
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Patent number: 9745546Abstract: The invention provides a device for growing cells—referred to as a cassette. The cell culturing device includes a housing that contains a lid having an optically clear window; a fluid distribution channel; a sample injection port fluidically connected to the fluid distribution channel; a base housing a porous media pad; and a media injection port fluidically connected to the media pad. The lid mates to the base to form a sterile seal; the fluid distribution channel is disposed over the media pad, which is viewable through the optical window; and sample fluid introduced into the fluid distribution channel is distributed evenly to the media pad, e.g., via a plurality of channels. The invention also provides kits that include cassettes of the invention and a tube set.Type: GrantFiled: November 7, 2012Date of Patent: August 29, 2017Assignee: Rapid Micro Biosystems, Inc.Inventors: Robert C. Aviles, Devin T. Michaud, Douglas J. Browne
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Patent number: 9090462Abstract: The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial enumeration tests based on the invention address an important problem in clinical and industrial microbiology—the long time needed for detection in traditional tests—while retaining key advantages of the traditional methods based on microbial culture. Embodiments of the invention include non-destructive aseptic methods for detecting cellular microcolonies without labeling reagents. These methods allow for the generation of pure cultures which can be used for microbial identification and determination of antimicrobial resistance.Type: GrantFiled: March 19, 2010Date of Patent: July 28, 2015Assignee: Rapid Micro Biosystems, Inc.Inventor: Don Straus
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Patent number: 9057046Abstract: The invention features devices for capturing and culturing cells (e.g., microorganisms, cells containing microorganisms, or cells from eukaryotic cell cultures) and methods of using these devices. One device is a cassette containing growth media that may be employed in an automated rapid enumeration system. The cassette has, for example, been enhanced with features for controlling surface flatness, optical imaging, controlled dehydration of semi solid nutrient media, controlled air and particle exchange, and automated handling. Another device of the invention is a filtration funnel that may used to concentrate cells in a sample onto a membrane.Type: GrantFiled: September 26, 2006Date of Patent: June 16, 2015Assignee: Rapid Micro Biosystems, Inc.Inventors: Douglas Browne, Don Straus, Chad Mace
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Publication number: 20140342447Abstract: The invention provides a device for growing cells—referred to as a cassette. The cell culturing device includes a housing that contains a lid having an optically clear window; a fluid distribution channel; a sample injection port fluidically connected to the fluid distribution channel; a base housing a porous media pad; and a media injection port fluidically connected to the media pad. The lid mates to the base to form a sterile seal; the fluid distribution channel is disposed over the media pad, which is viewable through the optical window; and sample fluid introduced into the fluid distribution channel is distributed evenly to the media pad, e.g., via a plurality of channels. The invention also provides kits that include cassettes of the invention and a tube set.Type: ApplicationFiled: November 7, 2012Publication date: November 20, 2014Applicant: RAPID MICRO BIOSYSTEMS, INC.Inventors: Robert C. Aviles, Devin T. Michaud, Douglas J. Browne
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Publication number: 20100248281Abstract: The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial enumeration tests based on the invention address an important problem in clinical and industrial microbiology—the long time needed for detection in traditional tests—while retaining key advantages of the traditional methods based on microbial culture. Embodiments of the invention include non-destructive aseptic methods for detecting cellular microcolonies without labeling reagents. These methods allow for the generation of pure cultures which can be used for microbial identification and determination of antimicrobial resistance.Type: ApplicationFiled: March 19, 2010Publication date: September 30, 2010Applicant: Rapid Micro Biosystems, Inc.Inventor: Don Straus