Patents Assigned to Rapid Pathogen Screening, Inc.
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Publication number: 20130017559Abstract: A lateral flow device may include one or more enhancement elements, where the enhancement elements bind to the analyte sandwich to increase a detection signal in the test zone. In preferred embodiments, some or all of the enhancement elements are encapsulated.Type: ApplicationFiled: September 19, 2012Publication date: January 17, 2013Applicant: RAPID PATHOGEN SCREENING, INC.Inventor: Rapid Pathogen Screening, Inc.
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Publication number: 20120264133Abstract: Point-of-care binding assays include at least one target nucleic acid binding in a multiplex structure with at least one sequence in a partner nucleic acid associated with a label, due to complementary base pairings between at least one sequence in the target nucleic acid and at least one sequence in the partner nucleic acid. The assays overcome the inherent deficiencies of antibody-protein antigen assays. In a preferred embodiment, color tagged nucleic acid sequences are used to bind a complementary target nucleic acid. The tagged nucleic acid sequences are preferably made from deoxyribonucleotides, ribonucleotides, or peptide nucleotides.Type: ApplicationFiled: June 25, 2012Publication date: October 18, 2012Applicant: RAPID PATHOGEN SCREENING, INC.Inventors: Robert P. Sambursky, Uma Mahesh Babu, Robert W. VanDine
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Publication number: 20120258469Abstract: Devices and methods incorporate mucolytic agents into a point-of-care testing device. The sample is loaded, and then the sample travels until it encounters one or more lysis agents and/or mucolytic agents. The mucolytic agent is preferably pre-loaded onto the collection device. In a preferred embodiment, the mucolytic agent is localized between the sample application zone and the conjugate zone. In embodiments with a sample compressor, one or more mucolytic agents may be pre-loaded and dried on the sample compressor, the sample collector, in various locations on the test strip, or in the running buffer.Type: ApplicationFiled: May 3, 2012Publication date: October 11, 2012Applicant: RAPID PATHOGEN SCREENING, INC.Inventors: Uma Mahesh Babu, Robert P. Sambursky
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Publication number: 20110136258Abstract: A sample compressor applies pressure to a sample collector and a sample application zone of a test strip to transfer a sample from the sample collector and a binding partner of an analyte to the sample application zone in a lateral flow device. At least one of the binding partners of the analyte is not located on the test strip prior to use of the lateral flow device. The test strip may be a universal test strip with no molecule that specifically binds the analyte is located on the test strip. The sample compressor may be a universal sample compressor also with no molecule that specifically binds the analyte on the sample compressor. The lateral flow device may also include one or more enhancement elements, where the enhancement elements bind to the analyte sandwich to increase a detection signal in the test zone.Type: ApplicationFiled: December 2, 2010Publication date: June 9, 2011Applicant: RAPID PATHOGEN SCREENING, INC.Inventors: Robert P. Sambursky, Uma Mahesh Babu, Robert W. VanDine, Ganga V. Kanaujia, Thomas Orsini
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Publication number: 20110086359Abstract: Assays and methods including mobile tagged single stranded nucleic acid reagents pre-loaded on an analysis device, which are preferably tagged, but not labeled and are complementary to a strand (preferably the anti-sense strand in double stranded DNA targets) of the target nucleic acid. The assay also includes a running buffer that includes a dye or other detectable label that nonspecifically binds only to double stranded nucleic acids. In addition, the analysis device includes a detection zone including one or more test zones that have an immobilized tag that binds to the tag on the mobile nucleic acid reagent.Type: ApplicationFiled: December 1, 2010Publication date: April 14, 2011Applicant: RAPID PATHOGEN SCREENING, INC.Inventors: Uma Mahesh Babu, Robert P. Sambursky, Robert W. VanDine
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Publication number: 20100297611Abstract: A lateral flow assay detects and differentiates between viral and bacterial infections. A combined point of care diagnostic device tests markers for viral infection and markers for bacterial infection, to effectively assist in the rapid differentiation of viral and bacterial infections. In one preferred embodiment, the bacterial marker is CRP. In another preferred embodiment, the viral marker is MxA. In some embodiments, it is unnecessary to lyse the cells in the sample prior to applying it to the device.Type: ApplicationFiled: May 18, 2010Publication date: November 25, 2010Applicant: RAPID PATHOGEN SCREENING, INC.Inventors: Robert P. Sambursky, Uma Mahesh Babu, Robert W. VanDine
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Publication number: 20100143891Abstract: More particularly, the present invention relates to a method for the detection of a target, e.g. pathogen in a human body fluid wherein a body fluid sample is collected with a swab member.Type: ApplicationFiled: February 8, 2010Publication date: June 10, 2010Applicant: RAPID PATHOGEN SCREENING, INC.Inventors: Franz Aberl, Marcus Scheibenzuber, Robert P. Sambursky, Robert W. VanDine, Jose S. Sambursky
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Patent number: 7723124Abstract: More particularly, the present invention relates to a method for the detection of a target, e.g. pathogen in a human body fluid wherein a body fluid sample is collected with a swab member.Type: GrantFiled: February 9, 2005Date of Patent: May 25, 2010Assignee: Rapid Pathogen Screening, Inc.Inventors: Franz Aberl, Marcus Scheibenzuber, Robert F. Sambursky, Robert W. Vandine, Jose S. Sambursky
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Publication number: 20100112725Abstract: The present invention includes methods and devices for preventing interfering substances from affecting the accuracy of a lateral flow immunoassay. In preferred embodiments, a test strip includes a capturing zone that includes at least one mobile capturing reagent that separates at least one interfering substance from the analyte. The capturing zone is preferably located upstream of the sample application zone. In some embodiments, the reagent/conjugate zone is also located upstream of the sample application zone. The capturing zone may be located upstream, downstream, or overlapping with the reagent/conjugate zone in these embodiments. In other preferred embodiments, one or more mobile capturing reagents are included in the elution medium/running buffer. In yet other embodiments, the capturing reagent is incorporated into a sample collection device of a sample collection system, preferably separate from the chromatographic test strip. A lysis zone is also included in some preferred embodiments.Type: ApplicationFiled: September 29, 2009Publication date: May 6, 2010Applicant: RAPID PATHOGEN SCREENING, INCInventors: Uma Mahesh Babu, Franz Aberl, Marcus Scheibenzuber, Robert P. Sambursky, Robert W. VanDine, Jose S. Sambursky
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Publication number: 20100015634Abstract: Devices and methods incorporate lysis agents into a point-of-care testing device. The sample is loaded, and then the sample travels until it encounters a lysis agent. The lysis agent is preferably pre-loaded onto the collection device. In a preferred embodiment, the initially lysis agent is localized between the sample application zone and the conjugate zone. The lysis agent is preferably soluble or miscible in the sample transport liquid, and the lysis agent is solubilized and activated upon contact with the sample transport liquid. The sample transport liquid then contains both lysis agent in solution or suspension and sample components in suspension. Any lysis-susceptible components in a sample, then being exposed in suspension to the lysis agent, are themselves lysed in situ. The running buffer then carries the analyte, including any lysis-freed components, to the detection zone.Type: ApplicationFiled: July 14, 2009Publication date: January 21, 2010Applicant: RAPID PATHOGEN SCREENING, INC.Inventors: Robert W. VanDine, Uma Mahesh Babu, Robert P. Sambursky
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Publication number: 20090305290Abstract: Point-of-care binding assays include at least one target nucleic acid binding in a multiplex structure with at least one sequence in a partner nucleic acid associated with a label, due to complementary base pairings between at least one sequence in the target nucleic acid and at least one sequence in the partner nucleic acid. The assays overcome the inherent deficiencies of antibody-protein antigen assays. In a preferred embodiment, color tagged nucleic acid sequences are used to bind a complementary target nucleic acid. The tagged nucleic acid sequences are preferably made from deoxyribonucleotides, ribonucleotides, or peptide nucleotides.Type: ApplicationFiled: July 14, 2009Publication date: December 10, 2009Applicant: RAPID PATHOGEN SCREENING, INC.Inventors: Robert P. Sambursky, Uma Mahesh Babu, Robert W. VanDine
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Publication number: 20090289201Abstract: The sensitivity of visually read lateral flow immunoassay tests is enhanced by adding a small quantity of fluorescing dye or fluorescing latex bead conjugates to the initial conjugate material. When the visible spectrum test line is visibly present, the test result is observed and recorded. However, in the case where the result is indeterminate, a light of an appropriate spectrum, such as a UV, visible, or infrared spectrum, is cast on the test line to excite and fluoresce the fluorescing latex beads which are bound in the test line in true positive tests to enhance the visible color at the test line.Type: ApplicationFiled: June 10, 2009Publication date: November 26, 2009Applicant: RAPID PATHOGEN SCREENING, INC.Inventors: Uma Mahesh Babu, Robert W. VanDine, Robert P. Sambursky, Ganga Kanaujia, Richard Rivas, JR.
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Publication number: 20090291508Abstract: The present invention includes methods and devices that detect target molecules in a biological sample. The sample analysis device of the present invention includes nanoparticles. In one embodiment, the nanoparticles are directly immobilized on the surface of the sample analysis device. In another embodiment, the nanoparticles are indirectly immobilized on the surface of the sample analysis device by incorporating them in appropriate media and immobilizing the nanoparticles within a matrix.Type: ApplicationFiled: May 20, 2009Publication date: November 26, 2009Applicant: Rapid Pathogen Screening Inc.Inventors: Uma Mahesh Babu, Robert W. VanDine, Robert P. Sambursky
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Publication number: 20070141564Abstract: More particularly, the present invention relates to a method for the detection of a target, e.g. pathogen in a human body fluid wherein a body fluid sample is collected with a swab member.Type: ApplicationFiled: January 26, 2007Publication date: June 21, 2007Applicant: RAPID PATHOGEN SCREENING INC.Inventors: Franz Aberl, Marcus Scheibenzuber, Robert Sambursky, Robert Vandine, Jose Sambursky
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Publication number: 20070059682Abstract: The present invention relates to a method for detecting an analyte in a sample, wherein the sample to be analyzed is applied to a chromatographic carrier. After separating from an interfering substance which may be present in the sample, the analyte of interest is detected on the carrier by means of an immunological assay. Further, a test strip for carrying out the method of the invention is provided. The invention further relates to a method for reducing interference in a method for detecting an analyte on a chromatographic carrier.Type: ApplicationFiled: September 13, 2005Publication date: March 15, 2007Applicant: Rapid Pathogen Screening Inc.Inventors: Franz Aberl, Marcus Schreibenzuber, Robert Sambursky, Robert Vandine, Jose Sambursky
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Publication number: 20050175992Abstract: More particularly, the present invention relates to a method for the detection of a target, e.g. pathogen in a human body fluid wherein a body fluid sample is collected with a swab member.Type: ApplicationFiled: February 9, 2005Publication date: August 11, 2005Applicant: RAPID PATHOGEN SCREENING INC.Inventors: Franz Aberl, Marcus Scheibenzuber, Robert Sambursky, Robert Vandine, Jose Sambursky