Abstract: A method of selecting a semaphorin for treating cancer in a subject is disclosed. The method comprises determining an expression of a semaphorin receptor on tumor cells of a tumor sample of the subject wherein an amount of the semaphorin receptor is indicative of the semaphorin suitable for treating the cancer in the subject. Methods of treating angiogenesis, kits for treating cancer and pharmaceutical compositions comprising semaphorins are also disclosed.
Type:
Application
Filed:
October 2, 2008
Publication date:
September 30, 2010
Applicant:
Rappaport Family Institute for Research Research in the Medical Sciences
Inventors:
Gera Neufeld, Boaz Kigel, Ofra Kessler, Asya Varshavsky