Abstract: One or more aspects of the technical solutions described herein facilitate using transdermal infrared optics to discover infraspectral markers. The infraspectral markers can predict presence/absence of one or more physiological state in a subject. One or more aspects of the technical solutions described herein further facilitate continuous monitoring and prediction of trends of a physiological state of a subject using non-invasive transdermal infrared optics. Further, one or more aspects of the technical solutions described herein facilitate personalized triage of and alerts for a subject based on continuous monitoring of non-invasive transdermal optical infraspectral markers.

Abstract: Transdermal optical sensing systems and methods of use and calibration are described. The systems include a master and secondary sensing device, an optical component arranged within the device, with an optical component surface exposed for contact with an epidermis of a subject, an optical emitter, an optical detector, and electronics including a controller configured to measure the light at the optical detector to determine the presence of one or more compounds within the epidermis, to perform a calibration of the sensing device including generating a master calibration curve, to detect a condition state of the sensing device, and to generate a biomarker correlation curve for a biomarker or combination of biomarkers.

Abstract: Method or system for monitoring a condition of an organ, which may be a donor organ, using an optical device; providing a reservoir of normothermic fluid; providing a perfusion circuit for the normothermic fluid; and providing a pump in fluid communication with perfusion circuit. Providing an oxygenator for normothermic fluid during circulation through the perfusion circuit to perfuse the donor heart with oxygenated blood; an optical device integrated within the reservoir, or pump or oxygenator, or in-line flow-based within perfusion circuit through normothermic fluid flows. May use total internal reflection for optical device. Monitoring condition of an organ, circulation system for blood, exterior to a body, but connected to the body; and adding filtration to blood, and filtered blood goes back into body. Monitoring a condition of a heart or lung, using extracorporeal membrane oxygenation (ECMO) to monitor the oxygenation levels in circulation.

Abstract: One or more aspects of the technical solutions described herein facilitate using transdermal infrared optics to discover infraspectral markers. The infraspectral markers can predict presence/absence of one or more physiological state in a subject. One or more aspects of the technical solutions described herein further facilitate continuous monitoring and prediction of trends of a physiological state of a subject using non-invasive transdermal infrared optics. Further, one or more aspects of the technical solutions described herein facilitate personalized triage of and alerts for a subject based on continuous monitoring of non-invasive transdermal optical infraspectral markers.

Abstract: Transdermal optical sensing systems and methods of use and calibration are described. The systems include a master and secondary sensing device, an optical component arranged within the device, with an optical component surface exposed for contact with an epidermis of a subject, an optical emitter, an optical detector, and electronics including a controller configured to measure the light at the optical detector to determine the presence of one or more compounds within the epidermis, to perform a calibration of the sensing device including generating a master calibration curve, to detect a condition state of the sensing device, and to generate a biomarker correlation curve for a biomarker or combination of biomarkers.

Abstract: A personalized assistance system includes an infrasensor device adapted to collect input data from a subject. A controller is configured to receive the input data from the infrasensor device. The controller has a processor and tangible, non-transitory memory on which instructions are recorded and is adapted to selectively execute one or more machine learning modules. Execution of the instructions by the processor causes the controller to extract one or more inframarkers from the input data. The controller is configured to determine respective changes in the inframarkers in real-time, including deviations from a respective baseline measurement customized for the subject. The controller is configured to determine at least one recommendation based in part on the inframarkers and the respective changes, via the one or more machine learning modules. The recommendation is executed when a predefined threshold is met.

Abstract: As described herein, a system includes an optical sensor, and a controller that detects progression of obstructive coronary artery disease using a sensor signal from the optical sensor. For example, the system is used for detecting an occlusion in a cardiovascular system of a user. A computer-implemented method for detecting the occlusion includes generating a light within a predetermined spectral range, the light directed towards a reflective element at a predetermined angle. The method further includes receiving a reflected light caused by a reflection of the light off of a reflecting element that is in contact with the user's epidermis. The method further includes detecting a concentration of a predetermined biomarker in a biofluid in the cardiovascular system based on variations in amplitude of the reflected light. The method further includes determining an occlusion in the cardiovascular system based on the concentration of the predetermined biomarker.