Abstract: A sensitive, precise detector system for physiological analytes uses a novel system. The system comprises an immobilized polyol on a surface. Reversibly coupled to the polyol or analyte is a dendrimer structure. In the system, a signal is triggered by the dendrimer structure when in a competitive environment with an analyte at the surface. In one embodiment, the system is an implantable sensor for use by diabetic patients. The sensing system can produce a consistent, measurable response while functioning under biologically relevant conditions. The sensing system requires the interaction of two components: 1) a competitive agent/signaling component, a dendrimer-boronic acid construct (DBA) and 2) a binding environment for a glucose-competitive DBA competition, which is an immobilized monosaccharide mimic (iDIOL).

Abstract: The fiber structures in the form of a fiber (or fiber mass), woven or nonwoven fabric, fiber absorbent layers, mats or bats or other collection of fiber can be modified to be microbiocidal, bacteriostatic, obtain immobilized, microbes, etc. The disclosed fiber has the unique ability to capture and hold microbes or microbial generating units within the fiber mass.

Abstract: Disclosed are filter media constituents, filter media, filter constructions, and methods of employing the filter media and filter constructions for fluid filtration. The filter media and filter media constituents of the invention have unique properties enabling the efficient capture of microbes or microbial generating units. Fluids usefully filtered using the filter media and filter constructions include air and water.

Abstract: The present invention relates to artificial receptors, arrays or microarrays of artificial receptors or candidate artificial receptors, methods of and compositions for making them, and methods of using them. Each artificial receptor includes a building block molecule that is a peptide of Formula: R1R2N—R3—(R4)n—X—(R5)m—Y—C(O)—R6, Tether-R1NH—Z-Ala-Gly-Ala-Gly-X-Ala-Y—C(O)—R6, R1R2NH—Z-Ala-Gly-Ala-Gly-X-Ala-Y—C(O)-Tether, Linker-R1NH—Z-Ala-Gly-Ala-Gly-X-Ala-Y—C(O)—R6, or R1R2NH—Z-Ala-Gly-Ala-Gly-X-Ala-Y—C(O)-Linker.

Abstract: The present invention relates to artificial receptors and arrays or microarrays of artificial receptors or candidate artificial receptors. Each member of the array includes a plurality of building block compounds, typically immobilized in a spot on a support. The present invention also includes the building blocks, combinations of building blocks, arrays of building blocks, and receptors constructed of these building blocks together with a support. The present invention also includes methods of making and using these arrays and receptors.

Abstract: The present invention relates to methods employing artificial receptors, such as combinatorial artificial receptor arrays. The present receptors include heterogeneous and immobilized combinations of building block molecules. In certain embodiments, combinations of 2, 3, 4, or 5 distinct building block molecules immobilized near one another on a support provide molecular structures that can be employed in the present methods. The present methods can develop artificial receptors that can then be employed to detect the receptor's ligand. The present methods can find compounds that disrupt one or more binding interactions.

Abstract: The present invention relates to artificial receptors on scaffolds, methods of and compositions for making them, and methods of using them. Each artificial receptor includes a plurality of building block compounds coupled to a scaffold. In an embodiment, at least one of the building blocks includes a tether moiety. The tether can provide spacing or distance between the recognition element and the scaffold to which the building block is immobilized. A tether moiety can have any of a variety of characteristics or properties including flexibility, rigidity or stiffness, ability to bond to another tether moiety, and the like.

Abstract: The present invention relates to sensors and sensor systems that utilize combinational artificial receptors. Embodiments of the present invention employ combinational artificial receptors in electromagnetic (e.g. optical) and electrochemical sensors.

Abstract: The present invention relates to artificial receptors, arrays or microarrays of artificial receptors or candidate artificial receptors, methods of and compositions for making them, and methods of using them. Each artificial receptor includes a plurality of building block compounds. In an embodiment, at least one of the building blocks includes a tether moiety. The tether can provide spacing or distance between the recognition element and the support or scaffold to which the building block is immobilized. A tether moiety can have any of a variety of characteristics or properties including flexibility, rigidity or stiffness, ability to bond to another tether moiety, and the like.

Abstract: The present invention relates to artificial receptors and arrays or microarrays of artificial receptors or candidate artificial receptors. Each member of the array includes a plurality of building block compounds, typically immobilized in a spot on a support. The present invention also includes the building blocks, combinations of building blocks, arrays of building blocks, and receptors constructed of these building blocks together with a support. The present invention also includes methods of making and using these arrays and receptors.

Abstract: The present invention relates to artificial receptors, arrays or microarrays of artificial receptors or candidate artificial receptors, methods of and compositions for making them, and methods of using them. Each artificial receptor includes a plurality of building block compounds. In an embodiment, at least one of the building blocks includes a tether moiety. The tether can provide spacing or distance between the recognition element and the support or scaffold to which the building block is immobilized. A tether moiety can have any of a variety of characteristics or properties including flexibility, rigidity or stiffness, ability to bond to another tether moiety, and the like.

Abstract: The present invention relates to a sensor system that can include a waveguide, a detection system that is operatively coupled to the waveguide, and a working artificial receptor. The waveguide can be operatively configured with respect to the working artificial receptor such that the waveguide is capable of receiving light from the working artificial receptor. The detection system can be configured to detect the electromagnetic radiation. The system can be configured to detect pathogenic microorganism, cancerous cell, pollutant in water, airborne pollutant, explosive-related vapor, protein, polynucleotide, or mixture thereof.

Abstract: The present invention relates to artificial receptors, arrays or microarrays of artificial receptors or candidate artificial receptors, methods of and compositions for making them, and methods of using them. Each artificial receptor includes a plurality of building block compounds. In an embodiment, at least one of the building blocks includes or is a peptide moiety. In an embodiment, the building block can be a peptide or peptidomimetic of Formula A: R1R2N—R3—(R4)n—X—(R5)m—Y—C(O)—R6 in which R1 and R2 can independently be hydrogen or any suitable blocking or protecting group for an amino-terminal nitrogen of a peptide. Suitable blocking or protecting groups include those described in Green, T W; Wuts, PGM (1999), Protective Groups in Organic Synthesis Third Edition, Wiley-Interscience, New York, 779 pp. In an embodiment, R1 or R2 is hydrogen. In an embodiment, R1 is hydrogen and R2 is R7(O)C—, in which R7 can be lower (e.g., C1 to C6) alkyl, substituted lower (e.g.

Abstract: The present invention relates to artificial receptors and arrays or microarrays of artificial receptors or candidate artificial receptors. Each member of the array includes a plurality of building block compounds, which can be immobilized in a spot on a support. The present invention also includes the building blocks, combinations of building blocks, arrays of building blocks, and receptors constructed of these building blocks together with a support. The present invention also includes methods of making and using these arrays and receptors.

Abstract: The present invention relates to artificial receptors, arrays or microarrays of artificial receptors or candidate artificial receptors, methods of and compositions for making them, methods of using them, and systems including them. The artificial receptor includes a plurality of building block compounds.

Abstract: The present invention relates to gradients of artificial receptors or building blocks, methods of making the gradients, and methods employing the gradients. The gradient can include one or more building blocks. The gradient can include change in any of a variety of characteristics of the artificial receptor or building block including change in the concentration of an artificial receptor or building block; change in the identity of an artificial receptor or building block; change in the topography of an artificial receptor or building block; change in the mode of binding of an artificial receptor or building block to the support; change in the lawn or lawn modifier; change in charge, volume, lipophilicity, or hydrophilicity of the artificial receptor or building block; or change in a molecular descriptors for the artificial receptor or building block.

Abstract: The present invention includes nanodevices employing combinatorial artificial receptors and methods for making and using the same. In an embodiment the invention includes a method of adhering components together. In an embodiment, the invention includes a device including a first component adhered to a second component via a binding pair of artificial receptors. In an embodiment, the invention includes an agent delivery device having a capsule, and an active agent. In an embodiment, the invention can include a detection device having a magnetic particle and an artificial receptor disposed thereon. In an embodiment, the invention can include a detection device having a quantum dot and an artificial receptor disposed on the quantum dot. In an embodiment, the invention includes a detection device having first particles and second particles that aggregate in the present of a target ligand. In an embodiment, the invention includes a detection device having a cantilever and an artificial receptor disposed thereon.

Abstract: The present invention relates to methods employing artificial receptors, such as combinatorial artificial receptor arrays. The present receptors include heterogeneous and immobilized combinations of building block molecules. In certain embodiments, combinations of 2, 3, 4, or 5 distinct building block molecules immobilized near one another on a support provide molecular structures that can be employed in the present methods. The present methods can develop artificial receptors that can then be employed to detect the receptor's ligand. The present methods can find compounds that disrupt one or more binding interactions.

Abstract: The present invention relates to building blocks for making or forming candidate artificial receptors. A building block can provide one or more structural characteristics such as positive charge, negative charge, acid, base, electron acceptor, electron donor, hydrogen bond donor, hydrogen bond acceptor, free electron pair, ? electrons, charge polarization, hydrophilicity, hydrophobicity, and the like. A building block can be bulky or it can be small.

Abstract: The present invention relates to sensors and sensor systems that utilize combinational artificial receptors. Embodiments of the present invention employ combinational artificial receptors in electromagnetic (e.g. optical) and electrochemical sensors.