Patents Assigned to Recherche et Industrie Therapeutiques
  • Vaccines against oedema disease of piglets
    Patent number: 4136181
    Abstract: Vaccines against oedema disease of piglets comprising an effective amount of E. coli neurotoxin isolated from a culture of an E. coli serotype which is capable of causing piglet oedema disease and adsorbed on an adjuvant. The vaccines are administered by intramuscular or subcutaneous route.
    Type: Grant
    Filed: December 29, 1977
    Date of Patent: January 23, 1979
    Assignee: Recherche et Industrie, Therapeutiques, RIT
    Inventors: Lucia Dobrescu, Constant Huygelen, Frans Van Wijnendaele
  • Intermediates for preparing .alpha.-carboxy-.alpha.-(3-thienyl)penicillin and cephalosporin derivatives
    Patent number: 4066664
    Abstract: A new process is disclosed for the preparation of alpha-carboxy-alpha-phenyl(or 3-thienyl)penicillin and cephalosporin derivatives.The process comprises reacting a 1.3-dioxane-4.6-dione derivative with the desired penicillanic or cephalosporanic acid derivative.
    Type: Grant
    Filed: September 27, 1976
    Date of Patent: January 3, 1978
    Assignee: Recherche et Industrie Therapeutiques
    Inventors: Pierre Crooij, Guy Simonet
  • Pre-farrowing pregnant sow piglet colibacillosis vaccines and process for their administration to pregnant sows before farrowing
    Patent number: 4053584
    Abstract: Piglet colibacillosis vaccine for intramuscular or subcutaneous administration to pregnant sows comprising cell-free heat labile (LT) E. coli enterotoxin with an adjuvant and the method for preventing piglet colibacillosis consisting in administering said vaccine to pregnant sows from 3 to 6 weeks before farrowing.
    Type: Grant
    Filed: March 29, 1976
    Date of Patent: October 11, 1977
    Assignee: Recherche et Industrie Therapeutiques
    Inventors: Lucia Dobrescu, Constant Huygelen
  • Varicella-zoster virus vaccine and preparation thereof
    Patent number: 4008317
    Abstract: Non-pathogenic varicella-zoster virus mutants are obtained by induction and isolation of temperature-sensitive mutant strains. N-methyl-N'-nitro-N-nitrosoguanidine is employed as mutagenic agent. The obtained mutants are useful for vaccine production.
    Type: Grant
    Filed: December 29, 1975
    Date of Patent: February 15, 1977
    Assignee: Recherche et Industrie Therapeutiques (R.I.T.)
    Inventor: Jacqueline Gits
  • 6-Aminopenicillanic acid derivative
    Patent number: 4002530
    Abstract: Penicillin derivative substituted at the 6 position with a (D)-[(2-amino-2-carboxy)-ethylthio]-acetamido group is obtained from Acremonium Chrysogenum new strain ATCC 20 389 or by semi-synthetic route. The product is an antibacterial agent.
    Type: Grant
    Filed: January 9, 1975
    Date of Patent: January 11, 1977
    Assignee: Recherche et Industrie Therapeutiques (R.I.T.)
    Inventors: Hugo Troonen, Piet Roelants, Bernard Boon
  • 7-(3-Substituted ureido) cephalosporins
    Patent number: 3994887
    Abstract: Cephalosporin compounds with 3-substituted ureido or -thioureido group at position 7 and hydrogen or heterocyclicthiomethyl groups at position 3 are prepared. These compounds are antibacterial agents.
    Type: Grant
    Filed: June 4, 1975
    Date of Patent: November 30, 1976
    Assignee: Recherche et Industrie Therapeutiques (R.I.T.)
    Inventors: Pierre Crooij, Alain Colinet
  • 7-(3-Substituted ureido) cephalosporins
    Patent number: 3994886
    Abstract: Cephalosporin compounds with 3-substituted ureido or -thioureido group at position 7 and hydrogen or heterocyclicthiomethyl groups at position 3 are prepared. These compounds are antibacterial agents.
    Type: Grant
    Filed: June 3, 1975
    Date of Patent: November 30, 1976
    Assignee: Recherche et Industrie Therapeutiques (R.I.T.)
    Inventors: Pierre Crooij, Alain Colinet
  • Live brovine adenovirus vaccines, preparation thereof and method of vaccination using them
    Patent number: 3962424
    Abstract: The invention relates to live virus vaccines containing temperature-sensitive mutant strains of bovine Adenovirus, the cut-off temperature of said mutant strain being comprised between 39.degree. and 40.degree. C.The invention also relates to the induction of said temperature-sensitive mutant strains and to a vaccination method by intranasal administration of the obtained vaccines.
    Type: Grant
    Filed: August 13, 1975
    Date of Patent: June 8, 1976
    Assignee: Recherche et Industrie Therapeutiques (R.I.T.)
    Inventors: Nathan Zygraich, Constant Huygelen
  • Live influenza type B virus vaccines and preparation thereof
    Patent number: 3962423
    Abstract: Attenuated stable influenza type B virus strains are obtained by recombining a vaccinal and previously attenuated influenza type B virus strain with an influenza type B virus isolate having the desired serotype and isolating a recombinant having at least one marker property of the attenuated parent strain which is not shared by the other parent strain and the antigenic composition of the other parent strain. The obtained strains are useful for the production of nasal influenza vaccines.
    Type: Grant
    Filed: April 18, 1975
    Date of Patent: June 8, 1976
    Assignee: Recherche et Industrie Therapeutiques (R.I.T.)
    Inventors: Julien Peetermans, Michele Lobmann, Jean-Marie Prevost, Emil Vascoboinic
  • Live influenza virus vaccines and preparation thereof
    Patent number: 3953592
    Abstract: Stable H.sub.3 N.sub.2 influenza virus strains completely resistant to serum inhibitors are obtained by passaging at least one time in the allantoic cavity of embryonated eggs in the presence of serum a recombinant strain previously obtained from an H.sub.3 N.sub.2 influenza strain and the A/PR.sub.8 influenza virus strain and isolating the so-obtained serum inhibitors resistant strains. The obtained strains are useful for vaccine production.
    Type: Grant
    Filed: September 27, 1973
    Date of Patent: April 27, 1976
    Assignee: Recherche et Industrie Therapeutiques (R.I.T.)
    Inventor: Julien Peetermans
  • 3-(1,3-Dithian-2-yl)-4-cyclo-pentene-2-carboxylic acids, esters and amides
    Patent number: 3947469
    Abstract: The invention relates to the stereoisomers of novel cyclopentene derivatives and to the preparation thereof.The cyclopentene derivatives are obtained by cycloaddition reaction between cyclopentadiene and a mono-or bis-thioalkyl (or aryl) ketene and reaction between the obtained product and a nucleophile agent.The compounds of the invention are intermediate products valuable for the preparation of different compounds, among which compounds of the prostaglandin type.
    Type: Grant
    Filed: September 9, 1974
    Date of Patent: March 30, 1976
    Assignee: Recherche et Industrie Therapeutiques (R.I.T.)
    Inventors: Leon Ghosez, Eric Cossement, Robert Biname