Abstract: Compounds of the formula ##STR1## (in which n is equal to 0 or represents a whole number from 1 to 10 and m represents the number 1 or 2) and their pharmacologically acceptable salts are prepared and have therapeutic, in particular hypolipemic, activity.
Type:
Grant
Filed:
February 6, 1978
Date of Patent:
May 8, 1979
Assignee:
Recherches Pharmaceutiques et Scientifiques
Inventors:
Christian J. M. Warolin, Pierre Muller, Roger Zaoui
Abstract: S-substituted cysteines, alkyl esters of S-substituted cysteines and S-substituted glutathiones in which the substituent on the S atom is allyl, geranyl, cinnamyl, benzylidene-3-butyl, 1-(para-chlorophenyl)ethyl and (pyridyl-3)methyl but excluding S-allyl cysteine bring about a reduction in atheromatic deposits in the aorta of test animals as well as a reduction in hypercholesterolemia and are of low toxicity. They may be used by the conventional routes for the treatment of human atheromatic conditions and disorders of the lipid metabolism.
Type:
Grant
Filed:
June 7, 1973
Date of Patent:
April 13, 1976
Assignee:
Recherches Pharmaceutiques et Scientifiques
Inventors:
Maurice Joullie, Lucien Lakah, Gabriel Maillard, Pierre Muller