Abstract: The invention relates to a controlled release composition comprising a combination of isosorbide dinitrate and hydralazine, such as hydralazine hydrochloride, that in operation delivers the drug in a pulsed or multi-modal manner for the treatment of angina, ischaemic heart disease, arterial hypertension and related disease conditions. Preferably, the isosorbide dinitrate and hydralazine hydrochloride can be released from the dosage form in an erodable, diffusion and/or osmotic-controlled release profile.
Type:
Grant
Filed:
March 4, 2015
Date of Patent:
April 12, 2016
Assignee:
Recro Technology LLC
Inventors:
Gurvinder Singh Rekhi, Richard Sidwell, Sharon Hamm