Abstract: The present invention relates to a device (100) for treating a vaginal lesion, by forming a coagulated blood mass, which is introduced by the device (100) into the vagina. The device (100) comprises an elongated guiding tube (102) having a lumen (104) for receiving whole blood and a plunger (112) having a piston element (114) fitted within the lumen (104) thus defining a blood coagulating space (109) between it and a blood-introducing end (106). The guiding tube (102) is configured for being introduced into the vagina and to discharge a coagulating blood mass formed within the lumen (104), in result of displacement of the displaceable piston (114) element. The coagulated blood mass may be maintained in the vagina by an anchoring element (122) configured to expand within the vagina and maintain there for a desired time and then be retrieved. Methods of treatment are also disclosed.

Abstract: An applicator for use in tissue treatment, a method and a kit using the same. The applicator includes (i) a first chamber for holding whole blood, (ii) a second chamber for holding a coagulation initiator, and (iii) a dispensing element configured for concomitantly receiving, upon actuating the applicator, a volume of whole blood from said first chamber and a volume of coagulation initiator from said second chamber and dispensing the two together onto a tissue in need of treatment.

Abstract: Device, method and assembly for wound treatment. Specifically a wound dressing device; an assembly, e.g. a kit-of-parts, including the device as a component; and method of wound dressing and use wherein the device is a key component. The device includes a cavity defined by concave walls surrounded by lips for attachment to skin in fluid tight manner and a closure removably fixed to the lips and sealing the cavity. The assembly also includes, as another component a device for introducing blood into the cavity after it is fixed over a wound to permit the blood to clot over the wound within the cavity. In use, the clotting mold device is fixed on top of a wound, and blood is introduced into the mold space to permit the blood to clot within the mold space to form a blood clot over the wound.

Abstract: Wound dressing assembly including (i) blood-clotting mold device having an enclosure defined between walls of a main body and a removable closure over an opening and configured for introduction of blood thereinto, and (ii) coagulation initiator in amount sufficient to coagulate blood introduced into the enclosure to form a blood clot. The formed blood clot is transferable onto a wound. Method for preparing a wound dressing by introducing a volume of blood into the enclosure of the blood-clotting mold device, maintaining the blood within the enclosure for time sufficient to permit clotting of the blood to obtain a blood clot; removing said the closure to open the enclosure; and extracting the blood clot from the enclosure. The formed blood clot may be used in a method for dressing a wound by fixation of the clot onto the wound.

Abstract: Provided is a wound dressing prepared from whole blood that is clotted ex vivo to form a sheet of clotted blood that is applied onto the skin over a sight of skin injury.

Abstract: Provided is a wound dressing prepared from whole blood that is clotted ex vivo to form a sheet of clotted blood that is applied onto the skin over a sight of skin injury.