Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

Abstract: The present invention is directed to compositions and methods for treating inflammatory diseases comprising administration of compositions that effect glycogen synthase kinase 3? (GSK-3?) protein or gene. The present invention also comprises methods and compositions for the identification of compounds or therapeutic agents which modulate the activity of the protein. The present invention provides compositions for and methods off treatment of biological conditions including, but not limited to, type I and type II diabetic induced vasculopathy, other vasculopathies, asthma and inflammation-induced diseases such as atherosclerosis and cell proliferation.

Abstract: The present invention is directed to compositions and methods for measuring enzymatic activity, particularly glycosidase activity. Methods of the present invention include assays for quantitatively determining the amount of glycosidase activity in a sample. The present invention also provides methods for the diagnosis of metastatic and inflammatory processes in vitro and in vivo. The present invention further provides compositions and methods for high throughput assays for identifying compounds that effect glycosidase activity.