Patents Assigned to REDWOOD BIOSCIENCE, INC.
  • Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
    Patent number: 11180451
    Abstract: The present disclosure provides conjugate structures and hydrazinyl-pyrrolo compound structures used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: November 23, 2021
    Assignee: Redwood Bioscience, Inc.
    Inventors: David Rabuka, Aaron Edward Albers, Romas Alvydas Kudirka, Albert W. Garofalo
  • Anti-HER2 antibody-maytansine conjugates and methods of use thereof
    Patent number: 11097013
    Abstract: The present disclosure provides anti-HER2 antibody-maytansine conjugate structures. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: August 24, 2021
    Assignee: Redwood Bioscience, Inc.
    Inventors: David Rabuka, Aaron Edward Albers, Robyn M. Barfield, Gregory W. deHart, Penelope M. Drake, Romas Alvydas Kudirka, Albert W. Garofalo, Jesse M. McFarland
  • Hydrazinyl-indole compounds and methods for producing a conjugate
    Patent number: 10888623
    Abstract: The present disclosure provides conjugate structures (e.g., polypeptide conjugates) and hydrazinyl-indole compounds used to produce these conjugates. The disclosure also provides methods of production of such conjugates, as well as methods of using the same.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: January 12, 2021
    Assignee: Redwood Bioscience, Inc.
    Inventors: Romas Alvydas Kudirka, Aaron Edward Albers, Robyn M. Barfield, David Rabuka
  • Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
    Patent number: 10604483
    Abstract: The present disclosure provides conjugate structures and hydrazinyl-pyrrolo compound structures used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: March 31, 2020
    Assignee: Redwood Bioscience, Inc.
    Inventors: David Rabuka, Aaron Edward Albers, Romas Alvydas Kudirka, Albert W. Garofalo
  • ANTIBODY SPECIFIC FOR CD22 AND METHODS OF USE THEREOF
    Publication number: 20190352395
    Abstract: The present disclosure provides antibodies specific for an epitope present on CD22. The antibodies are useful in various treatment, diagnostic, and monitoring applications, which are also provided.
    Type: Application
    Filed: February 28, 2019
    Publication date: November 21, 2019
    Applicant: Redwood Bioscience, Inc.
    Inventors: David RABUKA, Robert George Edward HOLGATE, Francis Joseph CARR
  • Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
    Patent number: 10464894
    Abstract: The present disclosure provides conjugate structures and hydrazinyl-pyrrolo compound structures used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: November 5, 2019
    Assignee: Redwood Biosciences, Inc.
    Inventors: David Rabuka, Aaron Edward Albers, Romas Alvydas Kudirka, Albert W. Garofalo
  • Hydrazinyl-indole compounds and methods for producing a conjugate
    Patent number: 10314919
    Abstract: The present disclosure provides conjugate structures (e.g., polypeptide conjugates) and hydrazinyl-indole compounds used to produce these conjugates. The disclosure also provides methods of production of such conjugates, as well as methods of using the same.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: June 11, 2019
    Assignee: Redwood Bioscience, Inc.
    Inventors: Romas Alvydas Kudirka, Aaron Edward Albers, Robyn M. Barfield, David Rabuka
  • Antibody specific for CD22 and methods of use thereof
    Patent number: 10259871
    Abstract: The present disclosure provides antibodies specific for an epitope present on CD22. The antibodies are useful in various treatment, diagnostic, and monitoring applications, which are also provided.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: April 16, 2019
    Assignee: Redwood Bioscience, Inc.
    Inventors: David Rabuka, Robert George Edward Holgate, Francis Joseph Carr
  • Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof
    Patent number: 10183998
    Abstract: The present disclosure provides aldehyde-tagged immunoglobulin (Ig) polypeptides that can be converted by a formylglycine-generating enzyme to produce a 2-formylglycine (FGly)-modified Ig polypeptide. An FGly-modified Ig polypeptide can be covalently and site-specifically bound to a moiety of interest to provide an Ig conjugate. The disclosure also encompasses methods of production of such aldehyde-tagged Ig polypeptides, FGly-modified Ig polypeptides, and Ig conjugates, as well as methods of use of same.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: January 22, 2019
    Assignee: Redwood Bioscience, Inc.
    Inventors: Robyn M. Barfield, Mark Alan Breidenbach, Gregory W. deHart, David Rabuka
  • Anti-HER2 antibody-maytansine conjugates and methods of use thereof
    Patent number: 10124070
    Abstract: The present disclosure provides anti-HER2 antibody-maytansine conjugate structures. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: November 13, 2018
    Assignee: Redwood Bioscience, Inc.
    Inventors: David Rabuka, Aaron Edward Albers, Robyn M. Barfield, Gregory W. deHart, Penelope M. Drake, Romas Alvydas Kudirka, Albert W. Garofalo, Jesse M. McFarland
  • Aldehyde-tagged protein-based drug carriers and methods of use
    Patent number: 9879249
    Abstract: The disclosure provides aldehyde-tagged protein carriers that can be covalently and site-specifically bound to drug to provide a drug-containing scaffold. The invention also encompasses methods of production of such drug-containing scaffolds and intermediates, as well as methods of use.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: January 30, 2018
    Assignee: Redwood Bioscience, Inc.
    Inventors: David Rabuka, Mark Alan Breidenbach
  • Hydrazinyl-indole compounds and methods for producing a conjugate
    Patent number: 9833515
    Abstract: The present disclosure provides conjugate structures (e.g., polypeptide conjugates) and hydrazinyl-indole compounds used to produce these conjugates. The disclosure also provides methods of production of such conjugates, as well as methods of using the same.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: December 5, 2017
    Assignee: Redwood Bioscience, Inc.
    Inventors: Romas Alvydas Kudirka, Aaron Edward Albers, Robyn M. Barfield, David Rabuka
  • Compounds and methods for producing a conjugate
    Patent number: 9579390
    Abstract: The present disclosure provides conjugate structures and compound structures used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
    Type: Grant
    Filed: May 5, 2015
    Date of Patent: February 28, 2017
    Assignee: Redwood Bioscience, Inc.
    Inventors: Romas Alvydas Kudirka, Aaron Edward Albers, David Rabuka
  • Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof
    Patent number: 9540438
    Abstract: The present disclosure provides aldehyde-tagged immunoglobulin (Ig) polypeptides that can be converted by a formylglycine-generating enzyme to produce a 2-formylglycine (FGly)-modified Ig polypeptide. An FGly-modified Ig polypeptide can be covalently and site-specifically bound to a moiety of interest to provide an Ig conjugate. The disclosure also encompasses methods of production of such aldehyde-tagged Ig polypeptides, FGly-modified Ig polypeptides, and Ig conjugates, as well as methods of use of same.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: January 10, 2017
    Assignee: Redwood Bioscience, Inc.
    Inventors: Robyn M. Barfield, Mark Alan Breidenbach, Gregory W. deHart, David Rabuka
  • Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
    Patent number: 9493413
    Abstract: The present disclosure provides conjugate structures and hydrazinyl-pyrrolo compound structures used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: November 15, 2016
    Assignee: Redwood Bioscience, Inc.
    Inventors: David Rabuka, Aaron Edward Albers, Romas Alvydas Kudirka, Albert W. Garofalo
  • Hydrazinyl-indole compounds and methods for producing a conjugate
    Patent number: 9310374
    Abstract: The present disclosure provides conjugate structures (e.g., polypeptide conjugates) and hydrazinyl-indole compounds used to produce these conjugates. The disclosure also provides methods of production of such conjugates, as well as methods of using the same.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: April 12, 2016
    Assignee: REDWOOD BIOSCIENCE, INC.
    Inventors: Romas Alvydas Kudirka, Aaron Edward Albers, Robyn M. Barfield, David Rabuka
  • Aldehyde-tagged protein-based drug carriers and methods of use
    Patent number: 9238878
    Abstract: The disclosure provides aldehyde-tagged protein carriers that can be covalently and site-specifically bound to drug to provide a drug-containing scaffold. The invention also encompasses methods of production of such drug-containing scaffolds and intermediates, as well as methods of use.
    Type: Grant
    Filed: February 16, 2010
    Date of Patent: January 19, 2016
    Assignee: Redwood Bioscience, Inc.
    Inventors: David Rabuka, Mark Alan Breidenbach
  • Antibody specific for CD22 and methods of use thereof
    Patent number: 9181343
    Abstract: The present disclosure provides antibodies specific for an epitope present on CD22. The antibodies are useful in various treatment, diagnostic, and monitoring applications, which are also provided.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: November 10, 2015
    Assignee: Redwood Bioscience Inc.
    Inventors: David Rabuka, Robert George Edward Holgate, Francis Joseph Carr
  • HYDRAZINYL-INDOLE COMPOUNDS AND METHODS FOR PRODUCING A CONJUGATE
    Publication number: 20140141025
    Abstract: The present disclosure provides conjugate structures (e.g., polypeptide conjugates) and hydrazinyl-indole compounds used to produce these conjugates. The disclosure also provides methods of production of such conjugates, as well as methods of using the same.
    Type: Application
    Filed: March 11, 2013
    Publication date: May 22, 2014
    Applicant: REDWOOD BIOSCIENCE, INC.
    Inventors: Romas Alvydas Kudirka, Aaron Edward Albers, Robyn M. Barfield, David Rabuka