Patents Assigned to REFORM BIOLOGICS, LLC
  • Excipient compounds for biopolymer formulations
    Patent number: 10478498
    Abstract: The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid protein formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions. The inventive methods can also yield a higher stability of a liquid protein formulation.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: November 19, 2019
    Assignee: REFORM BIOLOGICS, LLC
    Inventors: David S. Soane, Philip Wuthrich, Rosa Casado Portilla, Robert P. Mahoney, Mark Moody, Daniel G. Greene
  • Stabilizing excipients for therapeutic protein formulations
    Patent number: 10279048
    Abstract: The invention encompasses therapeutic formulations comprising a protein active ingredient and a stabilizing excipient, methods of improving stability in a therapeutic formulation comprising a protein active ingredient by adding a stability-improving amount of a stabilizing excipient to the therapeutic formulation, and methods of reducing adverse infusion-related effects in a patient, comprising administering to a patient in need thereof a therapeutic formulation comprising a protein active ingredient and a stabilizing excipient.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: May 7, 2019
    Assignee: REFORM BIOLOGICS, LLC
    Inventors: David S. Soane, Robert P. Mahoney, Philip Wuthrich, Daniel G. Greene
  • Stabilizing excipients for therapeutic protein formulations
    Patent number: 10016513
    Abstract: The invention encompasses therapeutic formulations comprising a protein active ingredient and a stabilizing excipient, methods of improving stability in a therapeutic formulation comprising a protein active ingredient by adding a stability-improving amount of a stabilizing excipient to the therapeutic formulation, and methods of reducing adverse infusion-related effects in a patient, comprising administering to a patient in need thereof a therapeutic formulation comprising a protein active ingredient and a stabilizing excipient.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: July 10, 2018
    Assignee: Reform Biologics, LLC
    Inventors: David S. Soane, Robert P. Mahoney, Philip Wuthrich, Daniel G. Greene
  • Viscosity-reducing excipient compounds for protein formulations
    Patent number: 9867881
    Abstract: The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: January 16, 2018
    Assignee: Reform Biologics, LLC
    Inventors: David S. Soane, Philip Wuthrich, Rosa Casado Portilla, Robert P. Mahoney, Mark Moody
  • Viscosity-reducing excipient compounds for protein formulations
    Patent number: 9605051
    Abstract: The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: March 28, 2017
    Assignee: REFORM BIOLOGICS, LLC
    Inventors: David S. Soane, Philip Wuthrich, Rosa Casado Portilla, Robert P. Mahoney, Mark Moody