Patents Assigned to REG Life Sciences, LLC.
  • Publication number: 20200232001
    Abstract: The disclosure relates to a recombinant microorganism engineered to express an enzyme which catalyzes the conversion of a primary amine and an acyl thioester to a fatty amide. The disclosure further encompasses a method of producing a fatty amide by culturing the recombinant microorganism in the presence of a carbon source.
    Type: Application
    Filed: August 22, 2019
    Publication date: July 23, 2020
    Applicant: REG Life Sciences, LLC
    Inventors: Jason J. LUTES, Stephen B. Del Cardayre
  • Publication number: 20190316099
    Abstract: Methods and compositions for producing fatty acid derivatives, for example, fatty esters, and commercial fuel compositions comprising fatty acid derivatives are described.
    Type: Application
    Filed: May 30, 2019
    Publication date: October 17, 2019
    Applicant: REG Life Sciences, LLC
    Inventor: Alfred GAERTNER
  • Patent number: 10392637
    Abstract: The disclosure relates to a recombinant microorganism engineered to express an enzyme which catalyzes the conversion of a primary amine and an acyl thioester to a fatty amide. The disclosure further encompasses a method of producing a fatty amide by culturing the recombinant microorganism in the presence of a carbon source.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: August 27, 2019
    Assignee: REG Life Sciences, LLC
    Inventors: Jason J. Lutes, Stephen B. Del Cardayre
  • Patent number: 10316298
    Abstract: Methods and compositions for producing fatty acid derivatives, for example, fatty esters, and commercial fuel compositions comprising fatty acid derivatives are described.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: June 11, 2019
    Assignee: REG Life Sciences, LLC
    Inventor: Alfred Gaertner
  • Patent number: 10301603
    Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: May 28, 2019
    Assignee: Reg Life Sciences, LLC
    Inventors: Derek L. Greenfield, Elizabeth J. Clarke, Eli S. Groban, Vikranth Arlagadda, Sungwon Lee, Xuezhi Li, Zhihao Hu, Baolong Zhu
  • Patent number: 10208294
    Abstract: The disclosure relates to acyl-ACP reductase (AAR) enzyme variants that result in improved fatty aldehyde and fatty alcohol production when expressed in recombinant host cells. The disclosure further relates to methods of making and using such AAR variants for the production of fatty alcohol compositions having particular characteristics.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: February 19, 2019
    Assignee: REG LIFE SCIENCES, LLC
    Inventors: Mathew Rude, Na Trinh, Andreas Schirmer, Jacob Gano
  • Publication number: 20190031594
    Abstract: Genetically engineered cells and microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use. The products are particularly useful as biofuels.
    Type: Application
    Filed: April 16, 2018
    Publication date: January 31, 2019
    Applicant: REG Life Sciences, LLC
    Inventors: Zhihao Hu, Fernando Valle
  • Publication number: 20190002845
    Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.
    Type: Application
    Filed: December 13, 2016
    Publication date: January 3, 2019
    Applicant: REG Life Sciences, LLC
    Inventors: Andreas Schirmer, Baolong Zhu, Emanuela Popova
  • Patent number: 10150975
    Abstract: Compositions and methods for producing aldehydes, alkanes, and alkenes are described herein. The aldehydes, alkanes, and alkenes can be used in biofuels.
    Type: Grant
    Filed: October 4, 2016
    Date of Patent: December 11, 2018
    Assignee: REG LIFE SCIENCES, LLC
    Inventors: Andreas W. Schirmer, Mathew A. Rude, Shane A. Brubaker
  • Patent number: 10017455
    Abstract: Genetically engineered cells and microorganisms are provided that produce fatty alcohols from the fatty acid biosynthetic pathway, as well as methods of their use.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: July 10, 2018
    Assignee: REG Life Sciences, LLC
    Inventors: Zhihao Hu, Fernando Valle
  • Patent number: 9951322
    Abstract: The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: April 24, 2018
    Assignee: REG Life Sciences, LLC
    Inventors: Louis Hom, Na Trinh, Murtaza Alibhai, Zhihao Hu, Eli Groban, Vikranth Arlagadda, Elizabeth Clarke
  • Publication number: 20180072645
    Abstract: The disclosure relates to the field of specialty chemicals. In particular, the disclosure provides novel 1,3-fatty-diol compounds and derivatives thereof which are useful e.g., in the production of personal care products, surfactants, detergents, polymers, paints, coatings, and as emulsifiers, emollients, and thickeners in cosmetics and foods, as industrial solvents and plasticizers, etc.
    Type: Application
    Filed: September 14, 2017
    Publication date: March 15, 2018
    Applicant: REG Life Sciences LLC
    Inventor: Haibo Wang
  • Patent number: 9890401
    Abstract: Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: February 13, 2018
    Assignee: REG LIFE SCIENCES, LLC
    Inventors: Zhihao Hu, Vikranth Arlagadda
  • Patent number: 9879239
    Abstract: The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant host cells that express such variants, cell cultures comprising the recombinant host cells and fatty acid ester compositions produced by such recombinant host cells.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 30, 2018
    Assignee: REG LIFE SCIENCES, LLC
    Inventors: Andrew M. Shumaker, Bernardo M. Da Costa, Kevin Holden, Louis G. Hom, Tarah S. Baron, Noah Helman
  • Patent number: 9873865
    Abstract: The disclosure relates to acyl-ACP reductase (AAR) enzyme variants that result in improved fatty aldehyde and fatty alcohol production when expressed in recombinant host cells. The disclosure further relates to methods of making and using such AAR variants for the production of fatty alcohol compositions having particular characteristics.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: January 23, 2018
    Assignee: REG LIFE SCIENCES, LLC
    Inventors: Mathew Rude, Na Trinh, Andreas Schirmer, Jacob Gano
  • Patent number: 9868682
    Abstract: The disclosure relates to a novel glycerol purification process that produces partially refined waste glycerol for a variety of industrial applications. The disclosure encompasses a salt-containing partially refined glycerol composition that is suitable as a fermentation grade glycerol.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: January 16, 2018
    Assignee: REG LIFE SCIENCES, LLC
    Inventors: Myong K. Ko, Fernando A. Sanchez-Riera, Simon Li, Perry Y. Liao
  • Publication number: 20170335295
    Abstract: Methods and compositions for producing fatty acid derivatives, for example, fatty esters, and commercial fuel compositions comprising fatty acid derivatives are described.
    Type: Application
    Filed: May 11, 2015
    Publication date: November 23, 2017
    Applicant: REG LIFE SCIENCES, LLC
    Inventor: Alfred GAERTNER
  • Publication number: 20170327799
    Abstract: Genetically engineered cells and microorganisms are provided that produce fatty alcohols from the fatty acid biosynthetic pathway, as well as methods of their use.
    Type: Application
    Filed: June 9, 2017
    Publication date: November 16, 2017
    Applicant: REG Life Sciences LLC
    Inventors: Zhihao Hu, Fernando Valle
  • Patent number: 9758769
    Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: September 12, 2017
    Assignee: REG LIFE SCIENCES, LLC
    Inventors: Derek L. Greenfield, Elizabeth Clarke, Eli Groban, Vikranth Arlagadda, Sungwon Lee, Xuezhi Li, Zhihao Hu, Baolong Zhu
  • Patent number: 9683219
    Abstract: The disclosure relates to acyl-ACP reductase (AAR) enzyme variants that result in improved fatty aldehyde and fatty alcohol production when expressed in recombinant host cells. The disclosure further relates to methods of making and using such AAR variants for the production of fatty alcohol compositions having particular characteristics.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: June 20, 2017
    Assignee: REG LIFE SCIENCES, LLC
    Inventors: Mathew Rude, Na Trinh, Andreas Schirmer, Jacob Gano