Patents Assigned to Rega Stichting, V.Z.W.
  • Process for the preparation of nucleotides
    Patent number: 5591852
    Abstract: The present invention relates to a novel and economical process for the synthesis of HPMP-substituted nucleotide antiviral compounds. Also disclosed are novel intermediates produced in the process for the preparation of HPMPC.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 7, 1997
    Assignees: Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v.z.w.
    Inventors: Purushotham Vemishetti, Paul R. Brodfuehrer, Henry G. Howell, Chester Sapino, Jr.
  • Process for the preparation of nucleotides
    Patent number: 5476938
    Abstract: The present invention relates to a novel and economical process for the synthesis of HPMP-substituted nucleotide antiviral compounds. Also disclosed are novel intermediates produced in the process for the preparation of HPMPC.
    Type: Grant
    Filed: January 21, 1992
    Date of Patent: December 19, 1995
    Assignees: Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v.z.w.
    Inventors: Purushortham Vemishetti, Paul R. Brodfuehrer, Henry G. Howell, Chester Sapino, Jr.
  • Antiviral (phosphonomethoxy)methoxy purine/pyrimidine derivatives
    Patent number: 5386030
    Abstract: The present invention concerns nucleotide analogs and their compositions and use. In particular it relates to novel (phosphonomethoxy) methoxy purine/pyrimidine derivatives.
    Type: Grant
    Filed: February 11, 1993
    Date of Patent: January 31, 1995
    Assignees: Institute of Organic Chemistry and Biochemistry of the Academy of Science of the Czech Republic, Rega Stichting v.z.w.
    Inventors: Choung U. Kim, John C. Martin, Bing Y. Luh, Peter F. Misco
  • Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
    Patent number: 5302585
    Abstract: The present invention provides chiral nucleotide analogs having the Formulas I and II ##STR1## and pharmaceutically acceptable salts and solvates thereof, and their pharmaceutical compositions for use in the treatment of viral infections, especially those caused by human immunodeficiency virus (HIV).
    Type: Grant
    Filed: July 22, 1992
    Date of Patent: April 12, 1994
    Assignees: Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v.z.w.
    Inventors: Kuo-Long Yu, Joanne J. Bronson, John C. Martin