Abstract: The present invention relates to a preparation method for a biodegradable polymer microparticle and a microparticle prepared by the method. More particularly, the present invention relates to a method for preparing a polymer microparticle, wherein the method includes the steps of: dissolving a biodegradable polyester-based polymer in DMSO (Dimethyl Sulfoxide); spraying the solution in a low temperature hydrocarbon solution to provide a frozen DMSO microparticle; adding the microparticle in a low temperature salt aqueous solution to dissolve DMSO; and removing salt. The present invention provides a method for preparing a novel polymer microsphere which can be injected through a syringe due to excellent physical properties (such as biocompatibility, biodegradability, porosity, mechanical strength) and the microcarrier's size-adjustability, and can be easily mass-produced.

Abstract: The present invention relates to a preparation method for a biodegradable polymer microparticle and a microparticle prepared by the method. More particularly, the present invention relates to a method for preparing a polymer microparticle, wherein the method includes the steps of: dissolving a biodegradable polyester-based polymer in DMSO (Dimethyl Sulfoxide); spraying the solution in a low temperature hydrocarbon solution to provide a frozen DMSO microparticle; adding the microparticle in a low temperature salt aqueous solution to dissolve DMSO; and removing salt. The present invention provides a method for preparing a novel polymer microsphere which can be injected through a syringe due to excellent physical properties (such as biocompatibility, biodegradability, porosity, mechanical strength) and the microcarrier's size-adjustability, and can be easily mass-produced.

Abstract: The present invention relates to a monoclonal antibody to human ?ig-h3 and the use thereof. More particularly, it relates to a monoclonal antibody to the human ?ig-h3 protein, wherein the epitope of the monoclonal antibody is the H1 region of the fourth fas-1 domain of the human ?ig-h3 protein. The monoclonal antibody can specifically recognize the human ?ig-h3 protein in tissue, and so will be useful in diagnosing a disease associated with the increase or decrease of the ?ig-h3 protein. In addition, the monoclonal antibody has the effect of inhibiting the cell adhesion activity of the ?ig-h3 protein.

Abstract: The present invention relates to a method for cell adhesion and wound healing with internal domains of ?ig-h3. Particularly, the present invention relates to the method of using recombinant proteins comprising one or more of 2nd or 4th internal domain of ?ig-h3 for cell adhesion and wound healing, wherein the 2nd or 4th internal domain of ?ig-h3 has aspartic acid and isoleucine essential for interaction with integrin which represent a high homology in base sequence of ?ig-h3 internal domains. The recombinant proteins comprising one or more 2nd or 4th internal domain of ?ig-h3 are effective for cell adhesion and wound healing by itself and can be used for developing cell culture medium and wound healing agent.

Abstract: The present invention relates to a composition for bone-filling, more particularly, to a bone-filling composition for stimulating bone-formation and bone consolidation comprising calcium sulfate and viscous biopolymers. The composition of the present invention can easily be administered into the missing part of injured bone. Since the composition of the present invention does not diffuse to surrounding organs, it can effectively be used for bone-filling material suitable for body.

Abstract: The present invention relates to peptides and derivatives thereof showing cell attachment, spreading and detachment activity. Particularly, the present invention relates to the peptide NKDIL (SEQ ID NO:2) and EPDIM (SEQ ID NO:3) and derivatives thereof which promote the cell attachment activity through interaction with ?3?1 integrin as a functional cell receptor and include aspartic acid and isoleucine essential for cell attachment and detachment activity. The peptides and derivatives thereof in the present invention can be used for developing a study of cell attachment activity mediated through various extracellular matrix protein containing ?ig-h3, wound healing, tissue regeneration and metastasis inhibition.

Abstract: The present invention relates to an extract of Houttuynia cordata and Rubus coreanus, and a composition for the prevention and treatment of allergic diseases, comprising the same. The inventive extract and the composition comprising the same have the effect of preventing and treating allergic diseases by inhibiting the degranulation and histamine release of mast cells. Also, they show no cytotoxicity and thus can be safely use in vivo.

Abstract: The present invention relates to the use of a peptide that interacts with the ?v?3 integrin of endothelial cells. More particularly, the invention relates to a method for inhibiting endothelial cell adhesion, endothelial cell migration and/or angiogenesis, using a peptide consisting of at least 18 amino acids, comprising tyrosine-histidine (TY) or asparagines-histidine (NH), and at least three hydrophobic amino acids with bulky side chains; or equivalents thereof. Furthermore, the invention provides a method for treating or preventing angiogenesis-related diseases, using the peptide.

Abstract: The present invention relates to peptides and derivatives thereof showing cell attachment, spreading and detachment activity. Particularly, the present invention relates to the peptide NKDIL and EPDIM and derivatives thereof which promote the cell attachment activity through interaction with a ? 3? 1 integrin as a functional cell receptor and include aspartic acid and isoleucine essential for cell attachment and detachment activity. The peptides and derivatives thereof in the present invention can be used for developing a study of cell attachment activity mediated through various extracellular matrix protein containing ? ig-h3, wound healing, tissue regeneration and metastasis inhibition.

Abstract: The present invention relates to peptides and derivatives thereof showing cell attachment, spreading and detachment activity. Particularly, the present invention relates to the peptide NKDIL and EPDIM and derivatives thereof which promote the cell attachment activity through interaction with ?3?1 integrin as a functional cell receptor and include aspartic acid and isoleucine essential for cell attachment and detachment activity. The peptides and derivatives thereof in the present invention can be used for developing a study of cell attachment activity mediated through various extracellular matrix protein containing ?ig-h3, wound healing, tissue regeneration and metastasis inhibition.

Abstract: The present invention related to a functional agent for decomposing nicotine and a method of preparing the same. The agent includes natural plant extracts such as green tea leaves, mulberry leaves, ginkgo nuts, celery, lemon, apple, dried orange peel, and licorice root. The functional agent of the present invention facilitates the decomposition of nicotine and inhibits the generation of carcinogen. In addition, the functional agent shows an anti-oxidant effect, inhibits mutation and remarkably reduces the generation rate of lung cancer.