Patents Assigned to REGENERATIVE SCIENCES, LLC
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Patent number: 9700583Abstract: Compositions and methods are provided for the optimized expansion and implantation of mesenchymal stem cells into a patient in need thereof. Autologous mesenchymal stem cells (MSCs) to a patient in need of MSCs are harvested, expanded within novel growth parameters under the influence of autologous growth factors located on the patient's platelets.Type: GrantFiled: July 23, 2015Date of Patent: July 11, 2017Assignee: REGENERATIVE SCIENCES, LLCInventors: Christopher J. Centeno, Cristin Keohan
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Publication number: 20160002598Abstract: Device, system and method embodiments are disclosed herein which provide for the production of a modified autologous platelet solution at the patient bedside for contemporaneous reinjection to the patient. In certain embodiments all of the steps including, but not limited to blood draw, platelet lysis, solution preparation and reinjection to a patient may be accomplished in a single office or clinic visit without relocating the patient. Accordingly, the apparatus, devices and systems disclosed herein generally include a substantially stand-alone machine, device or system which is configured to accept a platelet containing solution, induce lysis of one or more platelet bodies within the platelet containing solution and provide the resulting modified platelet solution in a manner suitable for injection into the patient.Type: ApplicationFiled: January 28, 2014Publication date: January 7, 2016Applicant: Regenerative Science, LLCInventors: Christopher J. Centeno, Brian J. Leach, Ryan Dregalla, Patrick Reischling, Nicolette Lyons
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Patent number: 9168261Abstract: Autologous compositions and methods are provided for cartilage repair in patients in need thereof. Some aspects include combinations of platelet-based materials with chondrogenesis inducing agents in the presence or absence of cell-based therapies.Type: GrantFiled: June 28, 2013Date of Patent: October 27, 2015Assignee: Regenerative Sciences, LLCInventor: Christopher J. Centeno
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Patent number: 9113950Abstract: Methods and device are provided for delivery of biologics to an intervertebral disc. Device described herein include a needle assembly and handle assembly that optimize biologic delivery parameters to a target location within a disc. The needle assembly includes the capability of advancing into the disc at pre-configured pathways that allow for minimized damaged and maximized positioning of the biologic.Type: GrantFiled: November 4, 2010Date of Patent: August 25, 2015Assignee: Regenerative Sciences, LLCInventors: John Richard Schultz, Christopher J. Centeno
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Patent number: 8871199Abstract: Tissue repair in-vivo depends on acute inflammation, but in many clinical situations the other major components of healing such as blood supply, anabolic hormones, growth factors, and stem cells are lacking. This invention includes compositions consisting of an agent which induces an inflammatory healing response combined with an autologous platelet lysate at a specific concentration which may have demonstrated in-vitro abilities to expand autologous tissue repair cells.Type: GrantFiled: November 26, 2012Date of Patent: October 28, 2014Assignee: Regenerative Sciences, LLCInventor: Christopher J. Centeno
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Publication number: 20130108593Abstract: A system and method for the percutaneous, autologous transplantation of mesenchymal stem cells and progenitor helper cells (PHC) from bone marrow to degenerated intervertebral discs or joints. This method is designed to be used by operating room staff in a clinical setting to isolate a mesenchymal stem cell population and PHC during the same surgical procedure as transplantation. The method can be used as a two step procedure where cells are harvested, then isolated, then reimplanted at a later time. In addition, experimental techniques are described to determine which bone marrow cells should be removed via negative selection to generate a PHC population most likely to regenerate certain tissue types in-vitro as well as which combination of fibrinogen and hyaluronic acid and which degree of gel maceration provides the best matrix for in-vitro and in-vivo regeneration of joints and intervertebral discs.Type: ApplicationFiled: December 21, 2012Publication date: May 2, 2013Applicant: Regenerative Sciences, LLCInventor: Regenerative Sciences, LLC
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Publication number: 20130084341Abstract: Tissue repair in-vivo depends on acute inflammation, but in many clinical situations the other major components of healing such as blood supply, anabolic hormones, growth factors, and stem cells are lacking. This invention includes compositions consisting of an agent which induces an inflammatory healing response combined with an autologous platelet lysate at a specific concentration which may have demonstrated in-vitro abilities to expand autologous tissue repair cells.Type: ApplicationFiled: November 26, 2012Publication date: April 4, 2013Applicant: REGENERATIVE SCIENCES, LLCInventor: Regenerative Sciences, LLC
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Publication number: 20110276001Abstract: Methods and device are provided for delivery of biologics to an intervertebral disc. Device described herein include a needle assembly and handle assembly that optimize biologic delivery parameters to a target location within a disc. The needle assembly includes the capability of advancing into the disc at pre-configured pathways that allow for minimized damaged and maximized positioning of the biologic.Type: ApplicationFiled: November 4, 2010Publication date: November 10, 2011Applicant: REGENERATIVE SCIENCES, LLCInventors: John Richard Schultz, Christopher J. Centeno
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Publication number: 20110245804Abstract: Compositions and methods are provided for repairing damaged avascular zones, including intervertebral disc, in a patient in need thereof.Type: ApplicationFiled: December 4, 2009Publication date: October 6, 2011Applicant: REGENERATIVE SCIENCES, LLCInventor: Christopher J. Centeno
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Publication number: 20110200642Abstract: Tissue repair in-vivo depends on acute inflammation, but in many clinical situations the other major components of healing such as blood supply, anabolic hormones, growth factors, and stem cells are lacking. This invention includes compositions consisting of an agent which induces an inflammatory healing response combined with an autologous platelet lysate at a specific concentration which may have demonstrated in-vitro abilities to expand autologous tissue repair cells.Type: ApplicationFiled: December 18, 2008Publication date: August 18, 2011Applicant: REGENERATIVE SCIENCES, LLCInventor: Christopher J. Centeno
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Publication number: 20110052533Abstract: Autologous compositions and methods are provided for cartilage repair in patients in need thereof. Some aspects include combinations of platelet-based materials with chondrogenesis inducing agents in the presence or absence of cell-based therapies.Type: ApplicationFiled: March 13, 2009Publication date: March 3, 2011Applicant: REGENERATIVE SCIENCES, LLCInventor: Christopher J. Centeno