Abstract: The disclosure relates to double-stranded ribonucleic acid (dsRNA) compositions targeting ANGPTL7. The invention also relates to methods of using such dsRNA compositions to inhibit expression of ANGPTL7 and to methods of treating ANGPTL7-associated disorders, e.g., glaucoma, using such dsRNA compositions.
Type:
Application
Filed:
October 1, 2022
Publication date:
December 12, 2024
Applicants:
ALNYLAM PHARMACEUTICALS, INC., REGENERON PHARMACEUTIALS, INC.
Inventors:
JAMES D. MCININCH, VASANT R. JADHAV, BHAUMIK A. PANDYA, ELENA CASTELLANOS-RIZALDOS, ADAM CASTORENO, CARMELO ROMANO, GAURANG PATEL, YING HU