Abstract: Ophthalmic formulations of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist are provided suitable for intravitreal administration to the eye. The ophthalmic formulations include a stable liquid formulation and a lyophilizable formulation. Preferably, the protein antagonist has the amino acid sequence shown in SEQ ID NO:4.
Type:
Grant
Filed:
June 14, 2007
Date of Patent:
October 27, 2009
Assignee:
Regeneron Pharmacuticals, Inc.
Inventors:
Eric Furfine, Daniel Dix, Kenneth S. Graham, Kelly Frye