Abstract: The present disclosure pertains to compositions comprising aflibercept and methods for producing such compositions in chemically defined media and using chromatography to reduce amounts of certain aflibercept variants.
Type:
Grant
Filed:
August 18, 2020
Date of Patent:
August 24, 2021
Assignee:
Regeneron Pharmnaceuticals, Inc.
Inventors:
Andrew Tustian, Ankit Vartak, Thomas Daly, Erica Pyles, Nisha Palackal