Abstract: Eye degradation such as may be associated with dry eye syndrome is inhibited or reversed by administration of an actin-sequestering peptide such as Thymosin ?4, an isoform of Thymosin ?4 or oxidized Thymosin ?4.

Abstract: A method of treatment for treating, inhibiting, reducing or at least partly preventing respiratory or pulmonary microbial infection or gastrointestinal disorder of tissue of a subject, includes administering to a subject an effective amount of a composition including a polypeptide including thymosin ?4 (TB4), an isoform of TB4, an N-terminal variant of TB4, a C-terminal variant of TB4, LKKTET or a conservative variant thereof, LKKTNT or a conservative variant thereof, TB4 sulfoxide, TB4ala, T?9, T?10, T?11, T?12, T?13, T?14, T?15, gelsolin, vitamin D binding protein (DBP), profilin, cofilin, adsevertin, propomyosin, fincilin, depactin, Dnasel, vilin, fragmin, severin, capping protein, ?-actinin, acumentin or a combination thereof, so as to inhibit the infection or disorder.

Abstract: A method of treatment for promoting regeneration or repair a damaged cardiovascular tissue, or for preventing damage to cardiovascular tissue, includes administering to the tissue a damage-treating or -preventing fragment of thymosin beta 4 (T?4), such as AcSDKP, or a stimulating agent that forms such a fragment of (T?4).

Abstract: Compositions and methods for treatment of skin utilizing thymosin ?4.

Abstract: A composition and method utilizes a substantially purified composition including an adhesive and a polypeptide containing amino acid sequence LKKTET or a conservative variant thereof.

Abstract: A method of treatment or prevention of damage due to ionizing radiation exposure involves administering to a subject in need of such treatment an effective amount of a composition containing 1) a compound including a radiation damage-inhibiting polypeptide containing amino acid sequence LKKTET (such as Thymosin ?4), a conservative variant of LKKTET, an actin-sequestering agent, an anti-inflammatory agent; 2) an agent which stimulates production of the compound in the subject; 3) an agent which regulates the compound in the subject; or 4) an antagonist of the compound, so as to inhibit radiation damage in the subject.

Abstract: A pharmaceutically acceptable composition and method for entering a cell nucleus utilizes a cell nucleus-entering polypeptide including at least one of amino acid sequence LKKTET, amino acid sequence LKKTNT or amino acid sequence KSKLKK, or a conservative variant thereof, linked to a physiologically active agent having at least one of therapeutic or diagnostic application in the cell nucleus.

Abstract: Microbial infections including anthrax infection, and gastrointestinal disorders, are treated or prevented by administration of an actin-sequestering peptide including amino acid sequence LKKTET, such as Thymosin ?4, an isoform of Thymosin ?4, oxidized Thymosin ?4, or T?4 sulfoxide.

Abstract: Blisters, sores or skin degradation associated with Epidermolysis Bullosa is treated or prevented by administration of an actin-sequestering peptide such as Thymosin &bgr;4, an isoform of Thymosin &bgr;4 or oxidized Thymosin &bgr;4.