Abstract: Disclosed is a method for treating or preventing GvHD in a transplant patient by administering to the patient autologous, ex vivo-modified and expanded CD4+CD25+Foxp3+CD127low T reg cells.
Abstract: Disclosed is a method for treating relapsing-remitting multiple sclerosis in a patient by administering to the patient autologous, ex vivo-expanded CD4+CD25+Foxp3+CD127low T reg cells when the patient is in remission. Also disclosed is a method of inhibiting the activity of autoimmune, autologous cytotoxic T and B cells in a patient suffering from relapsing-remitting multiple sclerosis, comprising administering a therapeutically effective amount of autologous CD4+CD25+Foxp3+CD127low T reg cells to the patient.
Type:
Grant
Filed:
February 21, 2014
Date of Patent:
November 24, 2015
Assignee:
REGENEX LLC
Inventors:
Svetlana Nunevna Bykovskaia, Daria Dmitrievna Eliseeva, Igor Alekseevich Zavalishin
Abstract: Disclosed is a method for treating relapsing-remitting multiple sclerosis in a patient by administering to the patient autologous, ex vivo-expanded CD4+CD25+Foxp3+CD127low T reg cells when the patient is in remission. Also disclosed is a method of inhibiting the activity of autoimmune, autologous cytotoxic T and B cells in a patient suffering from relapsing-remitting multiple sclerosis, comprising administering a therapeutically effective amount of autologous CD4+CD25+Foxp3+CD127low T reg cells to the patient.
Type:
Application
Filed:
February 21, 2014
Publication date:
June 19, 2014
Applicant:
REGENEX LLC
Inventors:
Svetlana Nunevna BYKOVSKAIA, Daria Dmitrievna ELISEEVA, Igor Alekseevich ZAVALISHIN
Abstract: Disclosed is a method for treating relapsing-remitting multiple sclerosis in a patient by administering to the patient autologous, ex vivo-expanded CD4+CD25+Foxp3+CD127low T reg cells when the patient is in remission. Also disclosed is a method of inhibiting the activity of autoimmune, autologous cytotoxic T and B cells in a patient suffering from relapsing-remitting multiple sclerosis, comprising administering a therapeutically effective amount of autologous CD4+CD25+Foxp3+CD127low T reg cells to the patient.
Type:
Grant
Filed:
February 15, 2013
Date of Patent:
April 15, 2014
Assignee:
Regenex LLC
Inventors:
Svetlana Nunevna Bykovskaia, Daria Dmitrievna Eliseeva, Igor Alekseevich Zavalishin
Abstract: Disclosed is a method for treating relapsing-remitting multiple sclerosis in a patient by administering to the patient autologous, ex vivo-expanded CD4+CD25+Foxp3+CD127lowT reg cells when the patient is in remission. Also disclosed is a method of inhibiting the activity of autoimmune, autologous cytotoxic T and B cells in a patient suffering from relapsing-remitting multiple sclerosis, comprising administering a therapeutically effective amount of autologous CD4+CD25?Foxp3+CD127lowT reg cells to the patient.
Type:
Application
Filed:
February 15, 2013
Publication date:
January 2, 2014
Applicant:
Regenex LLC
Inventors:
Svetlana Nunevna BYKOVSKAIA, Daria Dmitrievna ELISEEVA, Igor Alekseevich ZAVALISHIN